6-Chloro-3-pyridazinecarbonitrile
- CAS No.
- 35857-89-7
- Chemical Name:
- 6-Chloro-3-pyridazinecarbonitrile
- Synonyms
- 3-Chloro-6-cyanopyridazine;3-Chloro-6-cyanopyridazin...;6-Chloropyridazin-3-carbonitrile;6-Chloro-3-pyridazinecarbonitrile;3-Pyridazinecarbonitrile, 6-chloro-;6-Chloro-3-pyridazinecarbonitrile ISO 9001：2015 REACH
- CBNumber:
- CB2958460
- Molecular Formula:
- C5H2ClN3
- Molecular Weight:
- 139.54
- MDL Number:
- MFCD09835352
- MOL File:
- 35857-89-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
6-Chloro-3-pyridazinecarbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS13355 | 6-Chloropyridazine-3-carbonitrile 97% | 35857-89-7 | 1g | $50 | 2026-06-04 | Buy |
| Activate Scientific | AS13355 | 6-Chloropyridazine-3-carbonitrile 97% | 35857-89-7 | 5g | $172 | 2026-06-04 | Buy |
| Activate Scientific | AS13355 | 6-Chloropyridazine-3-carbonitrile 97% | 35857-89-7 | 25g | $416 | 2026-06-04 | Buy |
| Matrix Scientific | 057945 | 6-Chloropyridazine-3-carbonitrile | 35857-89-7 | 5.00g | $106 | 2026-05-18 | Buy |
| Matrix Scientific | 057945 | 6-Chloropyridazine-3-carbonitrile | 35857-89-7 | 10.00g | $178 | 2026-05-18 | Buy |
6-Chloro-3-pyridazinecarbonitrile Chemical Properties, Uses, Production
Uses
6-Chloropyridazine-3-carbonitrile is a reactant in the synthesis of spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors.
Synthesis
66346-83-6
35857-89-7
(1) A mixture of 6-chloropyridazine-3-carboxamide (15 g, 95.5 mmol) and pyridine (22.6 g, 23.1 mL, 286.6 mmol) was suspended in dichloromethane and cooled under argon protection to -30°C. Trifluoroacetic anhydride (TFAA) was added slowly and dropwise with stirring, keeping the temperature in the reaction system below -20°C. The reaction mixture was allowed to react at this temperature for 19.5 h. The reaction mixture was then stirred for 19.5 h. The reaction mixture was then allowed to warm up naturally to room temperature. The reaction mixture was poured into water (500 mL) and washed with water (4 x 500 mL) until the aqueous phase was light yellow. The organic phase was dried with anhydrous magnesium sulfate (MgSO), filtered through a pad of silica gel (50 mm diameter, 30 mm height) and concentrated under reduced pressure. The resulting solid was purified by medium pressure liquid chromatography (MPLC) with an eluent of 40% dichloromethane/20 equivalents of ethyl acetate/hexane to give 6-chloro-3-pyridazinecarbonitrile as a colorless solid (5.25 g, 59% yield). Mass spectrum (EI+): m/z 139 ([M]+). NMR hydrogen spectrum (250 MHz, CDCl) δ: 7.71 (d, J = 8 Hz, 1H); 7.83 (d, J = 8 Hz, 1H).
References
[1] Patent: US5994353, 1999, A
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3086 - 3100
[3] European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 111 - 117
6-Chloro-3-pyridazinecarbonitrile Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cato Research Chemicals Inc. | 020-81960175-877 18933936954 | tianwen.zhan@cato-chem.com | China | 7335 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 6-Chloro-3-pyridazinecarbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 6-Chloro-3-pyridazinecarbonitrile
35857-89-7
|
$1.00-200.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-25 | 6-Chloro-3-pyridazinecarbonitrile
35857-89-7
|
$115.00-650.00 | 5g | 99% | 50 | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-08-20 | 6-Chloro-3-pyridazinecarbonitrile
35857-89-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 6-Chloro-3-pyridazinecarbonitrile
35857-89-7
- $1.00-200.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 6-Chloro-3-pyridazinecarbonitrile
35857-89-7
- $115.00-650.00
- 99%
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- 6-Chloro-3-pyridazinecarbonitrile
35857-89-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
