MRT67307 2HCl
- CAS No.
- 1781882-89-0
- Chemical Name:
- MRT67307 2HCl
- Synonyms
- MRT67307 2HCl;MRT67307 HCl ，S7948;MRT 67307 dihydrochloride, 10 mM in DMSO
- CBNumber:
- CB29690121
- Molecular Formula:
- C26H37ClN6O2
- Molecular Weight:
- 501.07
- MDL Number:
- MOL File:
- 1781882-89-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
MRT67307 2HCl price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA020A6Q | N-(3-((5-Cyclopropyl-2-((3-(morpholinomethyl)phenyl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide dihydrochloride | 1781882-89-0 | 5mg | $62 | 2026-06-01 | Buy |
| ACHEMBLOCK | Y228036 | MRT 67307 dihydrochloride 97.00% | 1781882-89-0 | 50MG | $385 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228036 | MRT 67307 dihydrochloride 97.00% | 1781882-89-0 | 100MG | $695 | 2026-05-27 | Buy |
| Arctom | SLK-S7948 | MRT67307 HCl 99.80% | 1781882-89-0 | 5mg | $140 | 2026-05-26 | Buy |
| Arctom | SLK-S7948 | MRT67307 HCl 99.80% | 1781882-89-0 | 10mM(1mLinDMSO) | $188 | 2026-05-26 | Buy |
MRT67307 2HCl Chemical Properties, Uses, Production
Uses
MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].
Biological Activity
MRT67307 is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy. In macrophages, MRT67307 prevents the phosphorylation of IRF3 and the production of IFNβ. In wild-type MEFs, MRT67307 enhances the IL-1-stimulated phosphorylation of p105 at Ser933 and RelA at both Ser468 and Ser536, and also enhances IL-1-stimulated activation of NF-κB-dependent gene transcription. [1] MRT67307 increases IL-10 production and suppresses proinflammatory cytokine production via a cAMP response element-Binding protein (CREB)-regulated transcriptional coactivator (CRTC) 3 Dependent Mechanism. [2] In addition, MRT67307 inhibit ULK and block autophagy in MEF cells. [3]
storage
Desiccate at RT
References
[1] Clark K, et al. Biochem J. 2011, 434(1), 93-104. [2] Clark K, et al. Proc Natl Acad Sci U S A. 2012, 109(42), 16986-16991. [3] Petherick KJ, et al. J Biol Chem. 2015, 290(18), 11376-11383.
MRT67307 2HCl Preparation Products And Raw materials
Raw materials
Preparation Products
MRT67307 2HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1161 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
View Latest Price from MRT67307 2HCl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | MRT 67307 dihydrochloride
1781882-89-0
|
$52.00 | 99.75% | 10g | TargetMol Chemicals Inc. |
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- MRT 67307 dihydrochloride
1781882-89-0
- $52.00
- 99.75%
- TargetMol Chemicals Inc.
