3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
- CAS No.
- 10320-49-7
- Chemical Name:
- 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
- Synonyms
- (2-alpha-Naphthoylethyl)dimethylamine;3-(diMethylaMino)-1-(naphthalen-1-yl)pr;2-(Dimethylamino)ethyl 1-naphthyl ketone;3-(Dimethylamino)-1-(1-naphthyl)-1-propanone;3-(dimethylamino)-1-(phthalen-5-yl)propan-1-one;3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone;3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one;3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one;1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-
- CBNumber:
- CB2970905
- Molecular Formula:
- C15H17NO
- Molecular Weight:
- 227.3
- MDL Number:
- MFCD09753763
- MOL File:
- 10320-49-7.mol
- MSDS File:
- SDS
| Boiling point | 368.7±25.0 °C(Predicted) |
|---|---|
| Density | 1.072 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 8.78±0.28(Predicted) |
| Appearance | Colorless to light yellow Viscous liquid |
| InChI | InChI=1S/C15H17NO/c1-16(2)11-10-15(17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9H,10-11H2,1-2H3 |
| InChIKey | CXDXSNWZXJVDMC-UHFFFAOYSA-N |
| SMILES | C(C1=C2C(C=CC=C2)=CC=C1)(=O)CCN(C)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M205300 | 3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone | 10320-49-7 | 1g | $525 | 2021-12-16 | Buy |
| Matrix Scientific | 073627 | 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one 95+% | 10320-49-7 | 1g | $578 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD153888 | 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one | 10320-49-7 | 2g | $785 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD153888 | 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one | 10320-49-7 | 100mg | $77 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD153888 | 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one | 10320-49-7 | 250mg | $152.5 | 2021-12-16 | Buy |
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Chemical Properties,Uses,Production
Uses
3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone is a compound related to TMC207 which is used in the treatment of drug-resistant tuberculosis, and was studied for its anti-tubercular activity.
Synthesis
941-98-0
50-00-0
506-59-2
10320-49-7
1-Acetylnaphthalene (8 g, 0.047 mol), paraformaldehyde (2 g, 0.065 mol) and dimethylamine hydrochloride (5.3 g, 0.065 mol) were dissolved in ethanol (15 mL), followed by the addition of 0.6 mL of concentrated hydrochloric acid. The reaction mixture was heated to reflux for 12 hours, after which it was cooled to room temperature and refrigerated at -20 °C overnight. A white solid precipitated from the reaction mixture, which was separated by filtration and washed with ethanol. The resulting white solid was dissolved in water and 50% aqueous sodium carbonate solution (5.8 g, 0.54 mol) was slowly added. After stirring for 10-15 min, the aqueous phase was extracted with ethyl acetate (20 mL x 3), the organic layers were combined, washed sequentially with water (15 mL x 2) and saturated saline (15 mL x 2), and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to obtain the target compound 3-dimethylamino-1-(naphthalen-5-yl)acetone as a colorless oil (8 g, 70% yield).
References
[1] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 790 - 792
[2] Patent: EP2371819, 2011, A1. Location in patent: Page/Page column 7
[3] Patent: EP2573067, 2013, A1. Location in patent: Paragraph 0065; 0066
[4] Patent: TW2016/4185, 2016, A. Location in patent: Paragraph 0342; 0343
[5] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 10, p. 1019 - 1024
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12272 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29854 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2161 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9236 | 58 |
View Lastest Price from 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-25 | 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one
10320-49-7
|
US $0.00 / kg | 20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | |
 |
2025-08-08 | 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
10320-49-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-24 | 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
10320-49-7
|
US $10.00 / KG | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one
10320-49-7
- US $0.00 / kg
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
10320-49-7
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
10320-49-7
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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