3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
- CAS No.
- 10320-49-7
- Chemical Name:
- 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
- Synonyms
- 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one;(2-alpha-Naphthoylethyl)dimethylamine;3-(diMethylaMino)-1-(naphthalen-1-yl)pr;2-(Dimethylamino)ethyl 1-naphthyl ketone;3-(Dimethylamino)-1-(1-naphthyl)-1-propanone;3-(dimethylamino)-1-(phthalen-5-yl)propan-1-one;3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone;3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one;1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-
- CBNumber:
- CB2970905
- Molecular Formula:
- C15H17NO
- Molecular Weight:
- 227.3
- MDL Number:
- MFCD09753763
- MOL File:
- 10320-49-7.mol
- MSDS File:
- SDS
| Boiling point | 368.7±25.0 °C(Predicted) |
|---|---|
| Density | 1.072 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 8.78±0.28(Predicted) |
| Appearance | Colorless to light yellow Viscous liquid |
| InChI | InChI=1S/C15H17NO/c1-16(2)11-10-15(17)14-9-5-7-12-6-3-4-8-13(12)14/h3-9H,10-11H2,1-2H3 |
| InChIKey | CXDXSNWZXJVDMC-UHFFFAOYSA-N |
| SMILES | C(C1=C2C(C=CC=C2)=CC=C1)(=O)CCN(C)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS116688 | 3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one 97% | 10320-49-7 | 1g | $114 | 2026-06-04 | Buy |
| Activate Scientific | AS116688 | 3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one 97% | 10320-49-7 | 5g | $380 | 2026-06-04 | Buy |
| Matrix Scientific | 073627 | 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one | 10320-49-7 | 250.00mg | $37 | 2026-05-18 | Buy |
| Matrix Scientific | 073627 | 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one | 10320-49-7 | 1.00g | $97 | 2026-05-18 | Buy |
| Matrix Scientific | 073627 | 3-(Dimethylamino)-1-(naphthalen-5-yl)propan-1-one | 10320-49-7 | 5.00g | $326 | 2026-05-18 | Buy |
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Chemical Properties, Uses, Production
Uses
3-(Dimethylamino)-1-(1-Naphthalenyl)-1-Propanone is a compound related to TMC207 which is used in the treatment of drug-resistant tuberculosis, and was studied for its anti-tubercular activity.
Synthesis
941-98-0
50-00-0
506-59-2
10320-49-7
1-Acetylnaphthalene (8 g, 0.047 mol), paraformaldehyde (2 g, 0.065 mol) and dimethylamine hydrochloride (5.3 g, 0.065 mol) were dissolved in ethanol (15 mL), followed by the addition of 0.6 mL of concentrated hydrochloric acid. The reaction mixture was heated to reflux for 12 hours, after which it was cooled to room temperature and refrigerated at -20 °C overnight. A white solid precipitated from the reaction mixture, which was separated by filtration and washed with ethanol. The resulting white solid was dissolved in water and 50% aqueous sodium carbonate solution (5.8 g, 0.54 mol) was slowly added. After stirring for 10-15 min, the aqueous phase was extracted with ethyl acetate (20 mL x 3), the organic layers were combined, washed sequentially with water (15 mL x 2) and saturated saline (15 mL x 2), and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to obtain the target compound 3-dimethylamino-1-(naphthalen-5-yl)acetone as a colorless oil (8 g, 70% yield).
References
[1] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 790 - 792
[2] Patent: EP2371819, 2011, A1. Location in patent: Page/Page column 7
[3] Patent: EP2573067, 2013, A1. Location in patent: Paragraph 0065; 0066
[4] Patent: TW2016/4185, 2016, A. Location in patent: Paragraph 0342; 0343
[5] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 10, p. 1019 - 1024
3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yancheng ZhengChi biological and Technology Co, Ltd. | 0515-88230089 18014968800 | wzfan1984@163.com | China | 18 | 55 |
| Shanghai SynFarm Pharmaceutical Technology Co., Ltd. | 021-50793966 18917198199 | info@synfarm.com | China | 280 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Famo Bio-chemical Technology Company Ltd. | 021-36680027 15821745250 | fengqiang@famobiotech.com | China | 494 | 56 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Jiaxing Novartis Chemical Co., Ltd. | 18957373295 | China | 1579 | 58 | |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 | lzz841106@aliyun.com | China | 10244 | 55 |
| Guangzhou Ciming Biological Technology Co., Ltd. | 020-38082199,29065168,38082986,29878298,29866629,4000192398 | China | 826 | 60 | |
| Chengdu Miracle Pharmaceutical Co., Ltd. | 028-86136736 19130631884 | sales@mic-pharma.com | China | 346 | 56 |
View Latest Price from 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one
10320-49-7
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2026-03-20 | 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
10320-49-7
|
$10.00 | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
10320-49-7
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one
10320-49-7
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
10320-49-7
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-(dimethylamino)-1-(naphthalen-5-yl)propan-1-one
10320-49-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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