(R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
- CAS No.
- 139004-93-6
- Chemical Name:
- (R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
- Synonyms
- S-2-BOC-AMINOMETHYL-PIPERIDINE;S-2-BOC-AMINOMETHYL-PIPERIDINE-HCl;(S)-N-Boc-1-(2-piperidyl)methanamine;(S)-2-Boc-aminomethyl-piperidine >=95%;(S)-tert-Butyl (piperidin-2-ylMethyl)carbaMate;tert-butyl (S)-(piperidin-2-ylmethyl)carbamate;tert-Butyl ((2S)-piperidin-2-ylmethyl)carbamate;tert-butyl N-[[(2S)-2-piperidyl]methyl]carbamate;tert-butyl N-[(2S)-piperidin-2-ylmethyl]carbamate;(S)-2-[[(tert-Butoxycarbonyl)amino]methyl]piperidine
- CBNumber:
- CB31009236
- Molecular Formula:
- C11H22N2O2
- Molecular Weight:
- 214.3
- MDL Number:
- MFCD11975335
- MOL File:
- 139004-93-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (S)-2-Boc-aminomethyl-piperidine ≥95% | 900586 | 1G | $488 |
| (S)-2-Boc-aminomethyl-piperidine ≥95% | 900586 | 5G | $1320 |
| tert-butyl N-[[(2S)-2-piperidyl]methyl]carbamate 97.0% | P11097 | 1g | $50 |
| tert-butyl N-[[(2S)-2-piperidyl]methyl]carbamate 97.0% | P11097 | 5g | $220 |
| tert-butyl N-[[(2S)-2-piperidyl]methyl]carbamate 97.0% | P11097 | 10g | $440 |
| Boiling point | 321.8±15.0 °C(Predicted) |
|---|---|
| Density | 0.981±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 12.84±0.46(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | 11.71°(C=0.77g/100mI, CHCL3, 20°C, 589nm) |
| InChI | InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-8-9-6-4-5-7-12-9/h9,12H,4-8H2,1-3H3,(H,13,14)/t9-/m0/s1 |
| InChIKey | DIRUVVRMWMDZAE-VIFPVBQESA-N |
| SMILES | C(OC(C)(C)C)(=O)NC[C@@H]1CCCCN1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H318-H335 |
| Precautionary statements | P310-P261-P280 |
| WGK Germany | WGK 3 |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
(R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 900586 | (S)-2-Boc-aminomethyl-piperidine ≥95% | 139004-93-6 | 1G | $488 | 2023-06-20 | Buy |
| Sigma-Aldrich | 900586 | (S)-2-Boc-aminomethyl-piperidine ≥95% | 139004-93-6 | 5G | $1320 | 2023-06-20 | Buy |
| Synthonix | P11097 | tert-butyl N-[[(2S)-2-piperidyl]methyl]carbamate 97.0% | 139004-93-6 | 1g | $50 | 2026-05-06 | Buy |
| Synthonix | P11097 | tert-butyl N-[[(2S)-2-piperidyl]methyl]carbamate 97.0% | 139004-93-6 | 5g | $220 | 2026-05-06 | Buy |
| Synthonix | P11097 | tert-butyl N-[[(2S)-2-piperidyl]methyl]carbamate 97.0% | 139004-93-6 | 10g | $440 | 2026-05-06 | Buy |
(R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Uses
Chiral building block developed using Liverpool ChiroChem-patented technology.
Synthesis
![Carbamic acid, N-[[(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-piperidinyl]methyl]-, 1,1-dimethylethyl ester](/CAS/20200515/GIF/248914-23-0.gif)
248914-23-0
139004-93-6
The general procedure for the synthesis of tert-butyl (S)-(piperidin-2-ylmethyl)carbamate using the compound (CAS:248914-23-0) as starting material was as follows: all weights and volumes were calculated based on the amount of Intermediate 1. First, palladium carbon catalyst (0.15 wt%, 10% Pd/C, Johnson Matthey paste type 490) and acetic acid (0.73 v/v) were added to a THF solution of Intermediate 3. The hydrogenation reaction was carried out at 1200-1300 mbar and 40 °C under nitrogen protection. The conversion was completed after 21 hours of reaction. The catalyst was removed by filtration and the filter cake was washed with THF (2 x 2.2 v/v). The filtrates were combined and concentrated to about 2.8 volumes at 50°C jacket temperature and under reduced pressure. Toluene (2.6 volumes) was added and distillation was continued under reduced pressure and again concentrated to about 2.8 volumes. Subsequently, toluene (5 volumes) was added and extracted with aqueous citric acid (3 x 3 volumes; citric acid concentration: 450 g/L). The aqueous layers were combined and back-extracted with toluene (4 x 5 volumes). The pH of the aqueous layer was adjusted to >10 by the addition of 30% NaOH solution (~6.5 vol), and then the product was extracted with THF (3 × 5 vol). The organic layers were combined and dried with sodium sulfate (2 wt%). The sodium sulfate was removed by filtration and the filter cake was washed with THF (2 x 1.3 v/v). The filtrates were combined and concentrated to 4.25 volumes at 50°C jacket temperature and under reduced pressure. Methylcyclohexane (3 x 4.3 volumes) was added in three portions and distillation was continued. The solvent was further removed under reduced pressure (3 x 4.3 volumes). Methylcyclohexane (0.53 volume) was added and the suspension was cooled to -10°C over 4 hours and stirred at this temperature for 12 hours. The slurry was filtered, washed with pre-cooled methylcyclohexane (0.66 v/v, -10 to -5 °C) and dried at 50 °C jacket temperature to give tert-butyl (S)-(piperidin-2-ylmethyl)carbamate as a white solid. The calibration yield was 87% of the theoretical value.
References
[1] Patent: WO2009/34133, 2009, A1. Location in patent: Page/Page column 14-15
[2] Heterocycles, 1999, vol. 51, # 9, p. 2065 - 2072
(R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49968 | 58 |
View Lastest Price from (R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-27 | (R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
139004-93-6
|
$6.60 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- (R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
139004-93-6
- $6.60
- 97%-99%
- Career Henan Chemical Co
