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2,2-Dimethyl-malonic acid monomethyl ester

2,2-Dimethyl-malonic acid monomethyl ester Structure
2,2-Dimethyl-malonic acid monomethyl ester structure
CAS No.
13051-21-3
Chemical Name:
2,2-Dimethyl-malonic acid monomethyl ester
Synonyms
3-Methoxy-2,2-diMethyl-3-oxopropanoic acid;2,2-Dimethyl-malonic acid monomethyl ester;Propanedioic acid, 2,2-dimethyl-, 1-methyl ester
CBNumber:
CB31009847
Molecular Formula:
C6H10O4
Molecular Weight:
146.14
MDL Number:
MFCD09833517
MOL File:
13051-21-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:31
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2,2-Dimethyl-malonic acid monomethyl ester Properties

Melting point 35-38 °C
Boiling point 78.5 °C(Press: 20 Torr)
Density 1.0624 g/cm3
storage temp. Sealed in dry,Room Temperature
pka 2.92±0.36(Predicted)
Appearance Colorless to off-white <35°C Solid,>38°C Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2917198090

2,2-Dimethyl-malonic acid monomethyl ester price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 426232 3-Methoxy-2,2-dimethyl-3-oxopropanoic Acid ≥90% 13051-21-3 1g $358 2026-06-03 Buy
Usbiological 426232 3-Methoxy-2,2-dimethyl-3-oxopropanoic Acid ≥90% 13051-21-3 5g $644 2026-06-03 Buy
Usbiological 426232 3-Methoxy-2,2-dimethyl-3-oxopropanoic Acid ≥90% 13051-21-3 10g $941 2026-06-03 Buy
Matrix Scientific 199454 3-Methoxy-2,2-dimethyl-3-oxo-propanoic acid 13051-21-3 1.00g $352 2026-05-18 Buy
Matrix Scientific 199454 3-Methoxy-2,2-dimethyl-3-oxo-propanoic acid 13051-21-3 5.00g $1044 2026-05-18 Buy
Product number Packaging Price Buy
426232 1g $358 Buy
426232 5g $644 Buy
426232 10g $941 Buy
199454 1.00g $352 Buy
199454 5.00g $1044 Buy

2,2-Dimethyl-malonic acid monomethyl ester Chemical Properties, Uses, Production

Synthesis

Methanol

67-56-1

2,2,5,5-tetraMethyl-1,3-dioxane-4,6-dione

15568-97-5

2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER

13051-21-3

To a round-bottomed flask containing a solution of THF:MeOH (50 mL, 1:5, v/v) with KOH (46.46 mmol) was slowly added 2,2,5,5-tetramethyl-1,3-dioxane-4,6-dione (11.61 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the mixture was poured into a solution of 1 M HCl (50 mL) and extracted with ether. The organic phases were combined, washed with saturated brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give monomethyl 2,2-dimethylmalonate in 88% yield.

References

[1] European Journal of Medicinal Chemistry, 2013, vol. 64, p. 169 - 178

2,2-Dimethyl-malonic acid monomethyl ester Preparation Products And Raw materials

Raw materials

Methanol 2,2,5,5-tetraMethyl-1,3-dioxane-4,6-dione Tetrahydrofuran Potassium hydroxide

Preparation Products

Propanoic acid,3-chloro-2,2-dimethyl-3-oxo-,methyl ester

2,2-Dimethyl-malonic acid monomethyl ester Suppliers

Global Suppliers ( 54)
Supplier Tel Email Country ProdList Advantage
Changzhou Huanling Chemical Co., Ltd. 89803005 18206112582 info@huanlingchem.com China 983 68
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Shanghai Leto Pharmatech Co.,Ltd. 86-021-5821 5861; 18016401466 sales@letopharm.com China 235 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Mashilabs (Shanghai) Co.,Ltd. 19916721580 mafarm@126.com China 4534 58
Chengdu 3S Pharmaceutical Technology Co., Ltd. 028-62577698; 19950139520 cd_chemical@126.com China 292 56
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Supplier Advantage
Changzhou Huanling Chemical Co., Ltd. 68
Accela ChemBio Co.,Ltd. 64
Hangzhou Sage Chemical Co., Ltd. 58
Shanghai T&W Pharmaceutical Co., Ltd. 58
Shanghai Leto Pharmatech Co.,Ltd. 58
Bide Pharmatech Ltd. 60
Mashilabs (Shanghai) Co.,Ltd. 58
Chengdu 3S Pharmaceutical Technology Co., Ltd. 56
Shanghai HuanChuan Industry Co.,Ltd. 50
Cool Pharm, Ltd 58

View Latest Price from 2,2-Dimethyl-malonic acid monomethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Methoxy-2,2-dimethyl-3-oxopropanoic acid pictures 2026-08-25 3-Methoxy-2,2-dimethyl-3-oxopropanoic acid
13051-21-3
 $3.90-5.90 1KG 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER pictures 2019-12-26 2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER
13051-21-3
 $1.00 1g ≥98% Career Henan Chemical Co

2,2-Dimethyl-malonic acid monomethyl ester Spectrum

2,2-DIMETHYL-MALONIC ACID MONOMETHYL ESTER(13051-21-3)1HNMR

13051-21-3 (2,2-Dimethyl-malonic acid monomethyl ester) Related Search:

Bis[(12-crown-4)methyl] dodecylmethylmalonate Diethyl dibutylmalonate Diethyl 1,1-cyclobutanedicarboxylate Diethyl ethyl(isoamyl)malonate DIALLYL GLUTARATE
Dimethyl diethylmalonate Diethyl 2-ethyl-2-phenylmalonate Diethyl bis(hydroxymethyl)malonate Diethyl 1,1-cyclopropanedicarboxylate Diethyl dipropylmalonate
Diethyl bis(2-cyanoethyl)malonate Diethyl diethylmalonate Diethyl diallylmalonate Diethyl dimethylmalonate Diethyl 2-ethyl-2-(p-tolyl)malonate
Diethyl methylphenylmalonate Triethyl 1-cyano-3,3,4-pentane-tricarboxylate Allyl-1-methylbutyldiethyl malonate

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Propanedioic acid, 2,2-dimethyl-, 1-methyl ester 3-Methoxy-2,2-diMethyl-3-oxopropanoic acid 2,2-Dimethyl-malonic acid monomethyl ester 13051-21-3