4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
- CAS No.
- 28478-46-8
- Chemical Name:
- 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
- Synonyms
- Methyl 4-hydroxy-o-anisate;4-Hydroxy-2-Methoxy-Benzoicac;Methyl 4-hydroxy-2-methoxybenzoate;4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 4-hydroxy-2-methoxy-, methyl ester
- CBNumber:
- CB31010650
- Molecular Formula:
- C9H10O4
- Molecular Weight:
- 182.18
- MDL Number:
- MFCD06203815
- MOL File:
- 28478-46-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl4-Hydroxy-2-methoxybenzoate | M327263 | 250mg | $185 |
| Methyl4-hydroxy-2-methoxybenzoate | 2797AB | 250mg | $173 |
| Methyl4-Hydroxy-2-methoxybenzoate 97% | A251096 | 100mg | $64 |
| Methyl4-Hydroxy-2-methoxybenzoate 97% | A251096 | 250mg | $95 |
| Methyl4-Hydroxy-2-methoxybenzoate 97% | A251096 | 1g | $235 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2918999090 |
4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M327263 | Methyl4-Hydroxy-2-methoxybenzoate | 28478-46-8 | 250mg | $185 | 2021-12-16 | Buy |
| AK Scientific | 2797AB | Methyl4-hydroxy-2-methoxybenzoate | 28478-46-8 | 250mg | $173 | 2021-12-16 | Buy |
| Ambeed | A251096 | Methyl4-Hydroxy-2-methoxybenzoate 97% | 28478-46-8 | 100mg | $64 | 2021-12-16 | Buy |
| Ambeed | A251096 | Methyl4-Hydroxy-2-methoxybenzoate 97% | 28478-46-8 | 250mg | $95 | 2021-12-16 | Buy |
| Ambeed | A251096 | Methyl4-Hydroxy-2-methoxybenzoate 97% | 28478-46-8 | 1g | $235 | 2021-12-16 | Buy |
4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Chemical Properties,Uses,Production
Uses
Methyl 4-Hydroxy-2-methoxybenzoate is a reagent used in the synthesis of sphingosine-1-phosphate receptor agonist Ceralifimod used in the treatment of autoimmune diseases.
Synthesis
28478-45-7
28478-46-8
Step 3: A solution of EtOAc (200 mL) of methyl 2-methoxy-4-benzyloxybenzoate (40 g, 147 mmol) obtained in Step 2 was added to a Parr shaking flask, followed by 2 g of 10% Pd/C catalyst. The reaction mixture was placed in a Parr hydrogenation unit and shaken at 55 psi H2 pressure for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration under argon protection and the solvent was removed by distillation under reduced pressure. The resulting solid was washed with a small amount of EtOAc, filtered and dried under vacuum for 24 h to give methyl 2-methoxy-4-hydroxybenzoate in 99% yield.
References
[1] Patent: US5665719, 1997, A
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 12, p. 2146 - 2163
[3] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 21, p. 3081 - 3086
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1059 - 1062
[5] Journal of Medicinal Chemistry, 1985, vol. 28, # 6, p. 717 - 727
4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
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| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
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| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
View Lastest Price from 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
28478-46-8
|
US $1.00 / g | 1g | 98% | 100KG | Career Henan Chemical Co |
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- 4-HYDROXY-2-METHOXY-BENZOIC ACID METHYL ESTER
28478-46-8
- US $1.00 / g
- 98%
- Career Henan Chemical Co
