Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
- CAS No.
- 262295-94-3
- Chemical Name:
- Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- 4-(Boc-amino)picolinonitrile;tert-butyl 2-cyanopyridin-4-ylcarbamate;tert-butyl N-(2-cyano-4-pyridyl)carbamate;(2-Cyano-pyridin-4-yl)-carbamic acid tert-butyl ester;N-(2-cyano-4-pyridinyl)carbamic acid tert-butyl ester;Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester;Carbamic acid, N-(2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester;Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
- CBNumber:
- CB31053264
- Molecular Formula:
- C11H13N3O2
- Molecular Weight:
- 219.24
- MDL Number:
- MFCD11975697
- MOL File:
- 262295-94-3.mol
- MSDS File:
- SDS
Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | C38313 | tert-Butyl (2-cyanopyridin-4-yl)carbamate 95+% | 262295-94-3 | 100mg | $100 | 2026-05-06 | Buy |
| Synthonix | C38313 | tert-Butyl (2-cyanopyridin-4-yl)carbamate 95+% | 262295-94-3 | 250mg | $110 | 2026-05-06 | Buy |
| Synthonix | C38313 | tert-Butyl (2-cyanopyridin-4-yl)carbamate 95+% | 262295-94-3 | 1g | $440 | 2026-05-06 | Buy |
| Synthonix | C38313 | tert-Butyl (2-cyanopyridin-4-yl)carbamate 95+% | 262295-94-3 | 5g | $2200 | 2026-05-06 | Buy |
| aablocks | AA002SAJ | Tert-Butyl (2-Cyanopyridin-4-Yl)Carbamate 95% | 262295-94-3 | 250mg | $74 | 2026-05-28 | Buy |
Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Chemical Properties, Uses, Production
Synthesis
4248-19-5
62150-45-2
262295-94-3
GENERAL STEPS: To a solution of 4-bromopyridine-2-carbonitrile (20 g, 109.29 mmol) in 1,4-dioxane (300 mL) was added sequentially Pd(OAc)2 (2.98 g, 13.27 mmol), XPhos (18.9 g, 39.34 mmol) and Cs2CO3 (50.3 g, 154.38 mmol). The reaction mixture was stirred at 100 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and solid impurities were removed by filtration. The filtrate was concentrated under reduced pressure and purified by fast column chromatography (eluent: EtOAc/petroleum ether = 1/3, v/v) to afford the target compound tert-butyl (2-cyanopyridin-4-yl)carbamate as a yellow solid (23 g, 95% yield).LC-MS (ES, m/z): 220 [M + H]+. 1H NMR (300 MHz, CDCl3) : δ 8.49 (d, J = 5.6 Hz, 1H), 7.87 (d, J = 2.2 Hz, 1H), 7.43 (dd, J = 5.6, 2.2 Hz, 1H), 6.90 (s, 1H), 1.54 (s, 9H) ppm.
References
[1] Patent: US2016/243100, 2016, A1. Location in patent: Paragraph 0257-0258
Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
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| Shanghai Pengque Chemical Technology Co., LTD | 15317013857 15901926503 | pengque01@sina.com | China | 977 | 58 |
