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Fexaramine

Fexaramine structure

CAS No.: 574013-66-4

Chemical Name:: Fexaramine

Synonyms: CS-1691;Depasan;Actospar;Fexaramine;Fexaramine, 10 mM in DMSO;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr;(E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;(E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester

CBNumber:: CB31074393

Molecular Formula:: C32H36N2O3

Molecular Weight:: 496.64

MDL Number:: MFCD09971007

MOL File:: 574013-66-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Fexaramine ≥98% (HPLC)	SML1390	25MG	$637
Fexaramine ≥98% (HPLC)	SML1390	5MG	$150
Fexaramine ≥98%	17369	1mg	$36
Fexaramine ≥98%	17369	5mg	$135
Fexaramine ≥98%	17369	10mg	$219
More product size

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Fexaramine Properties

Boiling point	677.7±55.0 °C(Predicted)
Density	1.158±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO : 50 mg/mL (100.68 mM; Need ultrasonic)
form	powder
pka	4.95±0.24(Predicted)
color	white to beige
InChIKey	VLQTUNDJHLEFEQ-KGENOOAVSA-N
SMILES	C(OC)(=O)/C=C/C1=CC=CC(N(C(C2CCCCC2)=O)CC2=CC=C(C3=CC=C(N(C)C)C=C3)C=C2)=C1
FDA UNII	WTG9GFA65U
UNSPSC Code	12352116
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H413

Precautionary statements

P273-P301+P312+P330

WGK Germany

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Chronic 4

NFPA 704

	0
2		0

Fexaramine price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1390	Fexaramine ≥98% (HPLC)	574013-66-4	25MG	$637	2026-04-30	Buy
Sigma-Aldrich	SML1390	Fexaramine ≥98% (HPLC)	574013-66-4	5MG	$150	2025-07-31	Buy
Cayman Chemical	17369	Fexaramine ≥98%	574013-66-4	1mg	$36	2026-04-30	Buy
Cayman Chemical	17369	Fexaramine ≥98%	574013-66-4	5mg	$135	2026-04-30	Buy
Cayman Chemical	17369	Fexaramine ≥98%	574013-66-4	10mg	$219	2026-04-30	Buy

Product number	Packaging	Price	Buy
SML1390	25MG	$637	Buy
SML1390	5MG	$150	Buy
17369	1mg	$36	Buy
17369	5mg	$135	Buy
17369	10mg	$219	Buy

Fexaramine Chemical Properties,Uses,Production

Description

The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC₅₀ = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (; EC₅₀ = 80 nM). Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.

Uses

Fexaramine has been used to study its action on RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclastogenesis in mouse model.

Definition

ChEBI: Fexaramine is a member of biphenyls.

General Description

Fexaramine belongs to the nuclear hormone receptor family.

Biological Activity

Potent, selective farnesoid X receptor agonist (EC 50 = 25 nM). Displays no activity at hRXR α , hPPAR α , hPPAR γ , hPPAR δ , mPXR, hPXR, hLXR α , hTR β , hRAR β , mCAR, mERR γ and hVDR receptors.

Biochem/physiol Actions

Fexaramine might regulate lipid and glucose metabolism and can serve as a therapeutic target in the treatment of fatty liver disease, type 2 diabetes and obesity. Fexaramine might mediate cholesterol homeostasis and promotes osteoblast differentiation and suppresses differentiation of osteoclast.

storage

Desiccate at +4°C

References

[1] MICHAEL DOWNES. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.[J]. Molecular Cell, 2003, 11 4: 1079-1092. DOI: 10.1016/s1097-2765(03)00104-7

Fexaramine Preparation Products And Raw materials

Raw materials

Preparation Products

Fexaramine Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	963	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15058	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Henan Alfa Chemical Co., Ltd	+8618339805032	sale03@alfachem.cn	China	9817	58
Labnetwork lnc.	+86-27-50766799 +86-18062016861	contact@labnetwork.com	China	19981	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
TargetMol Chemicals Inc.	58
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58
BOC Sciences	58
Henan Alfa Chemical Co., Ltd	58
Labnetwork lnc.	58
InvivoChem	58

View Lastest Price from Fexaramine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Fexaramine 574013-66-4	$68.00-193.00		99.12%	10g	TargetMol Chemicals Inc.
	2019-09-06	Fexaramine 574013-66-4	$1.00	1KG	98%	20kg	Career Henan Chemical Co

Fexaramine
574013-66-4
$68.00-193.00
99.12%
TargetMol Chemicals Inc.

Fexaramine
574013-66-4
$1.00
98%
Career Henan Chemical Co

Fexaramine Spectrum

Fexaramine(574013-66-4)¹HNMR

574013-66-4(Fexaramine)Related Search:

PH-797804 RGB-286638 (free base) GSK2141795 SR9009 TD52

BAM15 (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide TG4-155 NVP-TAE684 Fexaramine

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Fexaramine 3-[3-[(Cyclohexylcarbonyl)[[4\'-(dimethylamino)[1,1\'-biphenyl]-4-yl]methyl]amino]phenyl]-2-Propenoic acid methyl ester, >98% CS-1691 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester 2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(diMethylaMino)[1,1'-biphenyl]-4-yl]Methyl]aMino]phenyl]-, Methyl ester (E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate (2E,4Z)-5-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)-4-(methoxycarbonyl)penta-2,4-dienoic acid 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr 2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-, methyl ester, (2E)- Actospar Depasan (E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate Fexaramine, 10 mM in DMSO 574013-66-4 C32H36N2O3 Inhibitors