1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1)
![1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1) Structure](CAS/20211123/GIF/1681020-60-9.gif)
- CAS No.
- 1681020-60-9
- Chemical Name:
- 1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1)
- Synonyms
- Venadaparib HCl;IDX-1197 hydrochloride;Venadaparib hydrochloride;4-(3-(3-((Cyclopropylamino)methyl)azetidine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one hydrochloride;1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1)
- CBNumber:
- CB310760063
- Molecular Formula:
- C23H24ClFN4O2
- Molecular Weight:
- 442.92
- MDL Number:
- MOL File:
- 1681020-60-9.mol
- MSDS File:
- SDS
1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1) Properties
| FDA UNII | ZJ8S8D3DK3 |
|---|
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1) price
1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1) Chemical Properties, Uses, Production
Uses
Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2].
in vivo
In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group[1].
IC 50
PARP1: 1.4 nM (IC50); PARP2: 1 nM (IC50)
References
[1] Yong Man Kim, et al. First-in-human dose-finding study of venadaparib (IDX-1197), a potent and selective PARP inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology. 39, no. 15_suppl (May 20, 2021) 3107-3107.
[2] Jae-Hoon Kang, et al. A novel phtalazinone derivatives and manufacturing process thereof. WO2015037939A1.
1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1) Preparation Products And Raw materials
Raw materials
Preparation Products
1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Shanghai Merlot Chemical Co., LTD | 15821661757 | 226174156@qq.com | China | 476 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Weijiahe Biotechnology Co., Ltd | 17502176150; 17502176150 | 861873257@qq.com | China | 2672 | 58 |
| Shanghai Anbida Biotechnology Co., Ltd. | 021-61629020 18201956406 | sales@ambeed.cn | China | 7032 | 58 |
1681020-60-9 (1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-, hydrochloride (1:1)) Related Search:
1of2
