4-Formylphenoxyacetic acid
- CAS No.
- 22042-71-3
- Chemical Name:
- 4-Formylphenoxyacetic acid
- Synonyms
- 4-Formyl-PAA;AKOS B004256;AKOS AU36-M42;ASISCHEM R21550;4-FORMYL-PAA LINKER;4-FORMYLPHENOXYACETIC ACID;P-FORMYLPHENOXYACETIC ACID;(4-formylphenoxy)-aceticaci;4-FormylphenoxyaceticAcid>2-(4-formylphenoxy)aceticaci
- CBNumber:
- CB3114243
- Molecular Formula:
- C9H8O4
- Molecular Weight:
- 180.16
- MDL Number:
- MFCD00016613
- MOL File:
- 22042-71-3.mol
- MSDS File:
- SDS
| Melting point | 193-196 °C |
|---|---|
| Boiling point | 272.96°C (rough estimate) |
| Density | 1.2933 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in hot methanol within almost transparency. |
| form | Crystalline Powder |
| pka | 3.04±0.10(Predicted) |
| color | Beige |
| Sensitive | Air Sensitive |
| BRN | 779885 |
| InChI | InChI=1S/C9H8O4/c10-5-7-1-3-8(4-2-7)13-6-9(11)12/h1-5H,6H2,(H,11,12) |
| InChIKey | OYNIIKHNXNPSAG-UHFFFAOYSA-N |
| SMILES | C(O)(=O)COC1=CC=C(C=O)C=C1 |
| CAS DataBase Reference | 22042-71-3(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, (4-formylphenoxy)- (22042-71-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P304+P340-P405-P501a-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Formylphenoxyacetic acid price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0319 | 4-Formylphenoxyacetic Acid >97.0%(HPLC)(T) | 22042-71-3 | 25g | $178 | 2021-12-16 | Buy |
| Apolloscientific | OR930525 | 4-Formylphenoxyacetic acid >96% | 22042-71-3 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR930525 | 4-Formylphenoxyacetic acid >96% | 22042-71-3 | 25g | $54 | 2026-06-04 | Buy |
| ChemScene | CS-0137169 | 4-Formylphenoxyacetic acid ≥98% | 22042-71-3 | 10g | $20 | 2026-06-04 | Buy |
| Apolloscientific | OR930525 | 4-Formylphenoxyacetic acid >96% | 22042-71-3 | 100g | $209 | 2026-06-04 | Buy |
4-Formylphenoxyacetic acid Chemical Properties, Uses, Production
Chemical Properties
BEIGE CRYSTALLINE POWDER
Uses
4-Formylphenoxyacetic acid is used as an organic chemical synthesis intermediate.
General Description
4-Formylphenoxyacetic acid is a formylphenoxyaliphatic acid that reacts with dimedone to form 1,8-dioxo-octahydroxanthenes. It participates in the synthesis of 4-substituted benzaldehyde derivatives and 4-carboxypheoxyacetic acid.
Synthesis
123-08-0
79-08-3
22042-71-3
The general procedure for the synthesis of 2-(4-formylphenoxy)acetic acid from p-hydroxybenzaldehyde and bromoacetic acid was as follows: potassium carbonate (24.9 g, 180.0 mmol) was added to a solution of 4-hydroxybenzaldehyde (10.0 g, 82.0 mmol) in acetone (150 mL) and the reaction mixture was stirred for 15 min at 40 °C. Subsequently, bromoacetic acid (12.0 g, 86.0 mmol) was added slowly in batches and the reaction mixture was heated to reflux for 18 hours. After completion of the reaction, the reaction mixture was cooled and diluted by adding water (200 mL). The reaction mixture was extracted with ethyl acetate (2 x 200 mL) and after combining the organic phases, the aqueous layer was adjusted to pH 2 with 6N hydrochloric acid. the aqueous layer was again extracted with ethyl acetate (2 x 400 mL), the organic phases were combined and washed with water (200 mL), dried with anhydrous sodium sulfate and finally concentrated under vacuum. The residue was ground with isohexane to afford the target compound 2-(4-formylphenoxy)acetic acid (13.5 g, 91% yield) as a creamy white solid.1H NMR (d6-DMSO) δ: 13.12 (br s, 1H), 9.87 (s, 1H), 7.88-7.85 (m, 2H), 7.12-7.10 (m, 2H). 4.83 (s, 2H).
References
[1] Patent: WO2015/86509, 2015, A1. Location in patent: Page/Page column 92; 93
[2] Main Group Metal Chemistry, 2015, vol. 38, # 5-6, p. 157 - 164
[3] Patent: WO2004/89945, 2004, A1. Location in patent: Page 8
[4] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 230 - 239
4-Formylphenoxyacetic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Yinghao Technology Development Co., Ltd | 15151934985 | sales@yingsapharm.com | China | 5455 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
View Latest Price from 4-Formylphenoxyacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 4-Formylphenoxyacetic acid
22042-71-3
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2019-07-06 | 2-(4-formylphenoxy)acetic acid
22042-71-3
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-Formylphenoxyacetic acid
22042-71-3
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-(4-formylphenoxy)acetic acid
22042-71-3
- $1.00
- 98%
- Career Henan Chemical Co
