Gestrinone
- CAS No.
- 16320-04-0
- Chemical Name:
- Gestrinone
- Synonyms
- ru2323;r-2323;A-46745;Dimetrose;NeMestran;TridoMose;gestrigone;GESTRINONE;Dimetriose;gestinone.
- CBNumber:
- CB3121391
- Molecular Formula:
- C21H24O2
- Molecular Weight:
- 308.41
- MDL Number:
- MFCD00865561
- MOL File:
- 16320-04-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 150-152°C |
|---|---|
| alpha | D20 +84.6° (c = 0.41 in methanol) |
| Boiling point | 388.8°C (rough estimate) |
| Density | 1.1040 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | -20°C Freezer |
| solubility |
DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM) DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM) Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM) |
| form | A crystalline solid |
| pka | 12.76±0.40(Predicted) |
| color | Off-white to light yellow |
| optical activity | [α]/D +81 to +88°, c =0.4 in ethanol |
| Merck | 14,4415 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1 |
| InChIKey | BJJXHLWLUDYTGC-ANULTFPQSA-N |
| SMILES | C1C2C(CC[C@]3([H])C=2C=C[C@@]2(CC)[C@@]3([H])CC[C@]2(C#C)O)=CC(=O)C1 |
| CAS DataBase Reference | 16320-04-0(CAS DataBase Reference) |
| FDA UNII | 1421533RCM |
| ATC code | G03XA02 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H362 |
| Precautionary statements | P201-P260-P263-P264-P270-P308+P313 |
| WGK Germany | WGK 3 |
| RTECS | JF7964000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Repr. 2 |
| Toxicity | mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988. |
Gestrinone price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10006488 | Gestrinone ≥98% | 16320-04-0 | 100mg | $175 | 2026-04-30 | Buy |
| Cayman Chemical | 10006488 | Gestrinone ≥98% | 16320-04-0 | 500mg | $788 | 2026-04-30 | Buy |
| Cayman Chemical | 10006488 | Gestrinone ≥98% | 16320-04-0 | 1g | $1313 | 2026-04-30 | Buy |
| Biosynth | FG156783 | Gestrinone | 16320-04-0 | 10mg | $250 | 2026-06-04 | Buy |
| Biosynth | FG156783 | Gestrinone | 16320-04-0 | 25mg | $334.5 | 2026-06-04 | Buy |
Gestrinone Chemical Properties, Uses, Production
Description
Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities. It is reported to be useful in the treatment of endometriosis and uterine leiom yomas.
Chemical Properties
Light Yellow Solid
Originator
Roussel UCLAF (France)
Uses
Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin. Controlled substance.
Definition
ChEBI: Gestrinone is an oxo steroid.
brand name
DIMETROSE
Side effects
Gestrinone, like danazol, inhibits the synthesis of estrogens and progestogens and has been used mainly to prepare patients with an endometrial disorder for hysterectomy. Its most common adverse effects are nausea, headache, mood changes, rash, hot flushes, weight gain, and discomfort in the joints and muscles. In some cases, there is evidence of masculinization.
Mode of action
The primary action of gestrinone is on the hypothalamic-pituitary axis, where it inhibits gonadotrophin release with a weak inhibitory effect on its synthesis. It also possesses anti-estrogen activity. The mode of action of gestrinone used for EC is probably inhibition of implantation by acting on the endometrium rather than inhibiting ovulation[1].
References
[1] Xuefeng Gao, Guian Chen, Erruo Wu . “Mechanism of emergency contraception with gestrinone: a preliminary investigation.” Contraception 76 3 (2007): Pages 221-227.
Gestrinone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Chengdu Ainahua Chemicals Co., Ltd. | 028-86612776; 13699069380 | 515238037@qq.com | China | 970 | 55 |
View Latest Price from Gestrinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-22 | Gestrinone
16320-04-0
|
1kg | 99% | 100kg | Dingwang Technology (Wuhan) Co., Ltd. | ||
 |
2021-07-02 | Gestrinone
16320-04-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-01-15 | Gestrinone
16320-04-0
|
$30000.00 | 100UG | 99.9% | 500KG | Hubei XinRunde Chemical Co., Ltd.
|
-
- Gestrinone
16320-04-0
- $0.00
- 99%
- Dingwang Technology (Wuhan) Co., Ltd.
-
- Gestrinone
16320-04-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Gestrinone
16320-04-0
- $30000.00
- 99.9%
- Hubei XinRunde Chemical Co., Ltd.
