Z-Guggulsterone
- CAS No.
- 39025-23-5
- Chemical Name:
- Z-Guggulsterone
- Synonyms
- GUGGULSTERONE;(Z)-Guggulsterone;GUGULSTERONE;Z-Gugglesterone;GUGGULSTERONE Z;GUGGULESTERONE Z;CIS GUGGULSTERONE;GUGGULSTERONE Z(P);Guggulsterone Z-RM;GUGGULSTERONE (Z FORM)
- CBNumber:
- CB4309068
- Molecular Formula:
- C21H28O2
- Molecular Weight:
- 312.45
- MDL Number:
- MFCD01310757
- MOL File:
- 39025-23-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 188-190° |
|---|---|
| alpha | D26 -61° (c = 1 in chloroform) |
| Boiling point | 463.3±45.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 5 mg/mL |
| form | powder |
| color | light yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Major Application |
forensics and toxicology veterinary |
| InChI | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1 |
| InChIKey | WDXRGPWQVHZTQJ-OSJVMJFVSA-N |
| SMILES | C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)/C(=C/C)/C(=O)C3)CC2 |
| LogP | 3.650 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | 6CST3U34GN |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335 | |||||||||
| Precautionary statements | P261-P271-P304+P340+P312-P403+P233-P405-P501 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37-38 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2914299000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | STOT SE 3 | |||||||||
| NFPA 704 |
|
Z-Guggulsterone price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1302214 | Guggulsterone Z United States Pharmacopeia (USP) Reference Standard | 39025-23-5 | 25mg | $485 | 2025-07-31 | Buy |
| Sigma-Aldrich | 78251 | (Z)-Guggulsterone analytical standard | 39025-23-5 | 10mg | $283 | 2022-05-15 | Buy |
| Cayman Chemical | 71800 | (Z)-Guggulsterone ≥95% | 39025-23-5 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 71800 | (Z)-Guggulsterone ≥95% | 39025-23-5 | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 71800 | (Z)-Guggulsterone ≥95% | 39025-23-5 | 10mg | $213 | 2026-04-30 | Buy |
Z-Guggulsterone Chemical Properties, Uses, Production
Description
Guggulsterone-(Z) (39025-23-5) is a natural steroid fromCommiphora mukulextract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1Attenuates astrocyte-mediated neuroinflammation.2 Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.4
Uses
Z-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.
Uses
(Z)-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.
Definition
ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.
Biological Activity
Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K i values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K i = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signalling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo . More active isomer of Guggulsterone (Pregna-4,17(20)-diene-3,16-dione ).
Biochem/physiol Actions
(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.
storage
Store at RT
References
[1] NANCY L. URIZAR. A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR[J]. Science, 2002, 296 5573. DOI:10.1126/science.1072891
[2] TIANLONG LIU. Z-Guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway[J]. Journal of Neurochemistry, 2018, 147 6: 803-815. DOI:10.1111/jnc.14583
[3] ANDREW AGBAY. Guggulsterone-releasing microspheres direct the differentiation of human induced pluripotent stem cells into neural phenotypes.[J]. Biomedical materials (Bristol, England), 2018, 13 3: 034104. DOI:10.1088/1748-605x/aaaa77
[4] FENG-GUO LIU. Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway.[J]. International Journal of Neuropsychopharmacology, 2017, 20 6: 485-497. DOI:10.1093/ijnp/pyx009
Z-Guggulsterone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Earlybird Industry Development Co.,Ltd. | +86-010-62256312-65 +86-13552740132 | info@earlybd.com | China | 134 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
View Latest Price from Z-Guggulsterone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | (Z)-Guggulsterone
39025-23-5
|
20MG | 99% HPLC | 100KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-07-27 | (Z)-Guggulsterone
39025-23-5
|
$91.00-261.00 | 98.93% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | (E)-Guggulsterone
39025-23-5
|
$1.00 | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- (Z)-Guggulsterone
39025-23-5
- $0.00
- 99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- (Z)-Guggulsterone
39025-23-5
- $91.00-261.00
- 98.93%
- TargetMol Chemicals Inc.
-
- (E)-Guggulsterone
39025-23-5
- $1.00
- 99%
- Career Henan Chemical Co
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