4-Bromo-2-fluoro-5-methylaniline
- CAS No.
- 418762-26-2
- Chemical Name:
- 4-Bromo-2-fluoro-5-methylaniline
- Synonyms
- 4-bromo-2-fluoro-5-methylailine;4-Bromo-2-fluoro-5-methylaniline;4-BROMO-2-FLUORO-5-METHYLANILINE 97%;4-Bromo-2-fluoro-5-methylbenzenamine;4-Bromo-2-fluoro-5-methyl-phenylamine;BenzenaMine,4-broMo-2-fluoro-5-Methyl-
- CBNumber:
- CB31264035
- Molecular Formula:
- C7H7BrFN
- Molecular Weight:
- 204.04
- MDL Number:
- MFCD04973744
- MOL File:
- 418762-26-2.mol
- MSDS File:
- SDS
| Boiling point | 229.5±35.0 °C(Predicted) |
|---|---|
| Density | 1.589±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.62±0.10(Predicted) |
| Appearance | Off-white to pink Solid |
| InChI | InChI=1S/C7H7BrFN/c1-4-2-7(10)6(9)3-5(4)8/h2-3H,10H2,1H3 |
| InChIKey | NBRIVALIHOZFTH-UHFFFAOYSA-N |
| SMILES | C1(N)=CC(C)=C(Br)C=C1F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2921430090 |
4-Bromo-2-fluoro-5-methylaniline price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 263987 | 4-Bromo-2-fluoro-5-methylaniline Asreported | 418762-26-2 | 2g | $319 | 2026-06-03 | Buy |
| Usbiological | 263987 | 4-Bromo-2-fluoro-5-methylaniline Asreported | 418762-26-2 | 5g | $410 | 2026-06-03 | Buy |
| Usbiological | 263987 | 4-Bromo-2-fluoro-5-methylaniline Asreported | 418762-26-2 | 10g | $531 | 2026-06-03 | Buy |
| Usbiological | 263987 | 4-Bromo-2-fluoro-5-methylaniline Asreported | 418762-26-2 | 25g | $744 | 2026-06-03 | Buy |
| Usbiological | 263987 | 4-Bromo-2-fluoro-5-methylaniline Asreported | 418762-26-2 | 50g | $1027 | 2026-06-03 | Buy |
4-Bromo-2-fluoro-5-methylaniline Chemical Properties, Uses, Production
Synthesis
452-84-6
418762-26-2
General procedure for the synthesis of 4-bromo-2-fluoro-5-methylaniline using 2-fluoro-5-methylaniline as starting material: 2-fluoro-5-methylaniline (6.75 g, 54 mmol) and calcium carbonate (10 g, 100 mmol) were suspended in a solvent mixture of dichloromethane (1 L) and methanol (400 mL). A solution of benzyltrimethylammonium tribromide (22.3 g, 57 mmol) in dichloromethane (180 mL) and methanol (70 mL) was slowly added dropwise with stirring. After the dropwise addition was completed, the reaction mixture was stirred at room temperature overnight and the color of the solution was observed to change to light orange to tan. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to remove the solvent. The concentrated residue was diluted with water (100 mL) and extracted with ether (3 x 200 mL). The organic phases were combined and purified by fast column chromatography (eluent ratio: n-hexane/ether 2:1 tapering to pure ether) to afford the target product 4-bromo-2-fluoro-5-methylaniline (9 g, yield 69.5%) as a white solid. The product was characterized by 1H-NMR (DMSO-d6): δ 7.23 (d, J = 10.8 Hz, 1H), 6.74 (d, J = 10.8 Hz, 1H), 5.27 (s, 2H), 2.20 (s, 3H).
References
[1] Patent: WO2007/64931, 2007, A2. Location in patent: Page/Page column 193-194
[2] Patent: WO2016/60941, 2016, A1. Location in patent: Page/Page column 46; 47
4-Bromo-2-fluoro-5-methylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing YakeLun Pharmaceutical Co., Ltd. | 025-66096098 3165145969 | sales@accoronpharm.com | China | 3924 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Beijing Eternalchem Co,. Ltd. | 010-59484199 18611897322;18611897322; | sales@eternalchem.com | China | 1993 | 60 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 |
View Latest Price from 4-Bromo-2-fluoro-5-methylaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 4-Bromo-2-fluoro-5-methylaniline
418762-26-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 4-Bromo-2-fluoro-5-methylaniline
418762-26-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 4-Bromo-2-fluoro-5-methylaniline
418762-26-2
|
$100.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-Bromo-2-fluoro-5-methylaniline
418762-26-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Bromo-2-fluoro-5-methylaniline
418762-26-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Bromo-2-fluoro-5-methylaniline
418762-26-2
- $100.00
- 98%
- Career Henan Chemical Co
