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4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol structure

CAS No.: 147118-36-3

Chemical Name:: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol

Synonyms: ZD-2 ;Rosuvastatin-Z7;4-(4-Fluorophenyl)-6;Rosuvastatin calciuM-Z7;Rosuvastatin Impurity 78;Rosuvastatin EP impurity Z7;Rosuvastatin Intermediate Z7;rosuvastatin interMediates Z-7;Rosuvastatin Pyrimidine Alcohol;Rosuvastatin Hydroxymethyl Impurity

CBNumber:: CB3129872

Molecular Formula:: C16H20FN3O3S

Molecular Weight:: 353.41

MDL Number:: MFCD08063917

MOL File:: 147118-36-3.mol

MSDS File:: SDS

Last updated:2026-05-28 00:57:10

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4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol Properties

Melting point	137-140°C
Boiling point	538.3±60.0 °C(Predicted)
Density	1.317±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	13.02±0.10(Predicted)
color	White to Light Yellow
InChI	InChI=1S/C16H20FN3O3S/c1-10(2)14-13(9-21)15(11-5-7-12(17)8-6-11)19-16(18-14)20(3)24(4,22)23/h5-8,10,21H,9H2,1-4H3
InChIKey	MSDYDUNHTAYBHV-UHFFFAOYSA-N
SMILES	CS(N(C1=NC(C(C)C)=C(CO)C(C2=CC=C(F)C=C2)=N1)C)(=O)=O
CAS DataBase Reference	147118-36-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
REACH Registrations	Active

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	012357	N-[4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide\|	147118-36-3	100mg	$418	2026-06-03	Buy
Biosynth	FF57578	N-(4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-Nmethylmethanesulfonamide	147118-36-3	25g	$900	2026-06-04	Buy
Biosynth	FF57578	N-(4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-Nmethylmethanesulfonamide	147118-36-3	250g	$900	2026-06-04	Buy
Biosynth	FF57578	N-(4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-Nmethylmethanesulfonamide	147118-36-3	100g	$900	2026-06-04	Buy
Biosynth	FF57578	N-(4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-Nmethylmethanesulfonamide	147118-36-3	50g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
012357	100mg	$418	Buy
FF57578	25g	$900	Buy
FF57578	250g	$900	Buy
FF57578	100g	$900	Buy
FF57578	50g	$900	Buy

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol Chemical Properties, Uses, Production

Synthesis

To a 500 mL three-necked flask, add 270 mL of tetrahydrofuran, 9.0 g (240 mmol) of sodium borohydride, and 22.8 g (60 mmol) (HPLC: 99.7%) of pyrimidinyl ester (II). Cool to 0 °C, and slowly add 34.2 g (240 mmol) of boron trifluoride diethyl ether complex. Heat to 60 °C and maintain the reaction temperature for 20 h. After the reaction is complete, cool to room temperature, and slowly add hydrochloric acid (v/v = 5%) to the reaction mixture. Stir for 1.5 h, then add saturated NaHCO3 to adjust the pH to 7–8. Extract with CH2Cl2 (60 mL × 2), separate the aqueous layer, dry the CH2Cl2 layer with anhydrous sodium sulfate, filter, and concentrate the filtrate to dryness under reduced pressure to obtain a pale yellow solid pyrimidinol (III). The yield was 20.49 g of 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol, with a yield of 96.7%.

Chemical Properties

White Solid

Uses

A Rosuvastatin (R700500) intermediate as HMG-CoA reductase inhibitor.

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol synthesis

Synthesis of 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol from 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol Suppliers

Global Suppliers ( 307)

Supplier	Tel	Email	Country	ProdList	Advantage
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD	793-33899567 13735087952	sales@afmpharm.com	China	51	61
XIANJU DOEASTCHEM Co., Ltd.	0576-87788985 13586230158	504833149@qq.com	China	31	58
Jiangsu Greature Bio-Medicine Co., Ltd.	0512-85557988 18662338937	frank.wang@greature.com.cn	China	145	58
Shanghai Mumin Biotechnology Co., Ltd	17177768578	alisa@pemichem.com	China	297	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50

Supplier	Advantage
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD	61
XIANJU DOEASTCHEM Co., Ltd.	58
Jiangsu Greature Bio-Medicine Co., Ltd.	58
Shanghai Mumin Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50

View Latest Price from 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol 147118-36-3		1KG	98%HPLC	1000 KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol 147118-36-3	$8.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-08-08	4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino]pyriminl-5-yl-methanol 147118-36-3		1KG	98.5%	200	Hangzhou ICH Biofarm Co., Ltd

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol
147118-36-3
$0.00
98%HPLC
WUHAN FORTUNA CHEMICAL CO., LTD

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol
147118-36-3
$8.00
99%
Henan Fengda Chemical Co., Ltd

4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino]pyriminl-5-yl-methanol
147118-36-3
98.5%
Hangzhou ICH Biofarm Co., Ltd

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol Spectrum

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol(147118-36-3)¹HNMR

147118-36-3 (4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol) Related Search:

Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate Rosuvastatin calcium 5-PyriMidinecarboxylic acid, 4-(4-fluorophenyl)-1,2-dihydro-6-(1-Methylethyl)-2-oxo-, Methyl ester Phosphonium, [[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]me Ethyl propionylacetate

Pitavastatin Impurity 8 3-Oxo Rosuvastatin SodiuM Salt Rosuvastatin ethyl ester Rosuvastatin EP impurity H Rosuvastatin IMpurity SodiuM Salt (5-Oxo Rosuvastatin SodiuM Salt)

Rosuvastatin Impurity 4 (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate

(4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide (4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate

1of4

4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDINE-5-METHANOL 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[(N-METHYL-N-METHYLSULFONYL)AMINO]PYRIMIDINE-5-YL-METHANOL 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDINE-5-ME Z-7: 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-Methyl-n-Methylsulfonyl)aMino]pyriMidine-5-yl-Methanol 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-Methyl-n-Methylsulfonyl)aMino] pyriMidine-5-yl-Methano 6-isopropyl-2-(N-Methyl-N-MethylsulphonylaMino)- Rosuvastatin CalciuM InterMediate Z7 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-Methyl-n-Methylsulfonyl)aMino]pyriMidine-5-yl-Methanol [4-(4-fluorophenyl0-6-isopropyl-2-(N-methyl-N-methylsulfonyl-amino)pyrimidin-5-yl]methano Rosuvastatin calcium intermediate R-1-2 Rosuvastatin Hydroxymethyl Impurity MethanesulfonaMide, N-[4-(4-fluorophenyl)-5-(hydroxyMethyl)-6-(1-Methylethyl)-2-pyriMidinyl]-N-Methyl- 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino) pyrimidin-5-methanol Z-7: 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[(N-METHYL 2-7:4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfony)aminolpyri 4-(4-Fluorophenyl)-6-Isopropyl-2-((N-Methyl-N-Methylsulfonyl)Amino)Pyrimidine-5-Yl-Methanol (Z-7) Rosuvastatin Impurity 78 4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropyl-2-(N-methylmethanesulfonylamino)pyrimidine Rosuvastatin Impurity (N-[4-(4-Fluorophenyl)-5-Hydroxymethyl-6-Isopropylpyrimidin-2-yl]-N-Methylmethanesulfonamide) 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-Methyl-N-Methylsufonyl)aMino]pyriMidine-5-yl-Methano 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-sulfonyl)amino]pyrimidine-5-yl-methanol. Rosuvastatin EP impurity Z7 Rosuvastatin-Z7 Rosuvastatin Pyrimidine Alcohol 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[ (N-... ZD-2 4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino]pyriminl-5-yl-methanol 5-(Hydroxymethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine Z-7:4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidine-5-Yl-Methonol 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[ (N-METHYL-N-METHYLSULFONYL)AMINO]PYRIMIDINE-5-YL-METHONOL N-(4-(4-Fluorophenyl)-5-hydroxymethyl-6-iso-propylpyrimidin-2-yl] -N-methylmethanesulfonamide 4-(4-Fluorophenyl)-6 N-(4-(4-fluorophenyl)-5-(hydroxyMethyl)-6-isopropylpyriMidin-2-y 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-Methyl-n-Meth rosuvastatin interMediates Z-7 Rosuvastatin calciuM-Z7 4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidin-5-Yl-Methanol (Methanol) 4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidine-5-yl-Methanol 4-(4-Fluorophenyl)-6-isopropyl-2- [(N-methyl-N- methylsulfony)amino]pyrimidine-5-yl-methanol 4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Mehyl-N-Mehylsulfonylamino)Pyrimidine-5-yl-Methanol Z-7 ：4-(4-Fluorophenyl)-6-isopropyl-2- [(N-methyl-N- methylsulfony)amino]pyrimidine-5-yl-methanol 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]PYRIMIDINE-5-METHANOL 4-(4-Fluorophenyl)-6-isopropyl-2-[m 4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n methylsulfonyl)amino]pyriminl-5-yl-methanol（Z7） 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl... Rosuvastatin Intermediate Z7 4-(4-Fluorophenyl)-6-Isopropyl-2[(N-methyl-N-methylsulphonyl)amino]pyrimidine-5-yl-methanol N-[4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide 147118-36-3 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-mesyl)amino]pyrimidine-5-methanol(Z7) 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol （Rosuvastatin calcium） 147118-36-3 C16H20N3O3FS Fluorine series INTERMEDIATES OF ROSUVASTATIN Rosuvastatin intermediates Rosuvastatin Calcium and its intermediates Heterocycles Inhibitors