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ChemicalBook >> CAS DataBase List >>Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Structure
Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- structure
CAS No.
2858800-98-1
Chemical Name:
Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-
Synonyms
OTUB1/USP8-IN-1;OTUB1/USP8-IN-1, 10 mM in DMSO;(R)-2-(2-Chloro-6-fluoro-3-((1-methylpyrrolidin-3-yl)oxy)phenyl)naphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-
CBNumber:
CB313103436
Molecular Formula:
C22H16ClFN2O4
Molecular Weight:
426.83
MDL Number:
MOL File:
2858800-98-1.mol
MSDS File:
SDS
Last updated:2025-10-29 15:43:00
Product description Number Pack Size Price
OTUB1/USP8-IN-1 98.31% CS-0617103 5mg $325
OTUB1/USP8-IN-1 98.31% CS-0617103 10mg $520
OTUB1/USP8-IN-1 98.31% CS-0617103 25mg $1029
OTUB1/USP8-IN-1 98.31% CS-0617103 50mg $1571
OTUB1/USP8-IN-1 98.31% CS-0617103 100mg $2437
Request For Quotation

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Properties

Boiling point 609.4±65.0 °C(Predicted)
Density 1.440±0.06 g/cm3(Predicted)
pka 8.72±0.40(Predicted)
form Solid
color Light yellow to yellow

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0617103 OTUB1/USP8-IN-1 98.31% 2858800-98-1 5mg $325 2026-06-04 Buy
ChemScene CS-0617103 OTUB1/USP8-IN-1 98.31% 2858800-98-1 10mg $520 2026-06-04 Buy
ChemScene CS-0617103 OTUB1/USP8-IN-1 98.31% 2858800-98-1 25mg $1029 2026-06-04 Buy
ChemScene CS-0617103 OTUB1/USP8-IN-1 98.31% 2858800-98-1 50mg $1571 2026-06-04 Buy
ChemScene CS-0617103 OTUB1/USP8-IN-1 98.31% 2858800-98-1 100mg $2437 2026-06-04 Buy
Product number Packaging Price Buy
CS-0617103 5mg $325 Buy
CS-0617103 10mg $520 Buy
CS-0617103 25mg $1029 Buy
CS-0617103 50mg $1571 Buy
CS-0617103 100mg $2437 Buy

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Chemical Properties,Uses,Production

Uses

OTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer[1].

in vivo

OTUB1/USP8-IN-1 (compound 61; 10 nM-10 μM; 72 h) decreases the tumor burden in the H1975 xenograft mouse model[1].

Animal Model:Female BALB/c nude mice with H1975 xenografts (5 weeks of age)[1]
Dosage:5 mg/kg
Administration:Intraperitoneal injection; QD and BID, for 2 weeks
Result:Reduced total tumor weight and average tumor volume in an over twofold with BID dosing.
Animal Model:Female BALB/c nude mice with H1975 xenograft (5 weeks of age)[1]
Dosage:1 and 10 mg/kg
Administration:Intravenous injection (1 mg/kg) and oral administration (10 mg/kg)
Result:1.19
Administrationi.v. (1 mg/kg)p.o. (10 mg/kg)
T1/2 (h)0.831.75
Tmax (h)0.33
Cmax (μg/L)4274
AUC (μg·h/L)13453747
CL (L/h/kg)44
Vdss (L/kg)0.77

References

[1] Tan L, et, al. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem. 2022 Oct 11. DOI:10.1021/acs.jmedchem.2c00408

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9855 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 7232 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Zibo Hangyu Biotechnology Development Co., Ltd 13053322091 13053322091 admin@mopaikeji.com China 1612 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Sangon Biotech (Shanghai) Co.,Ltd. -- Sales@sangon.com China 6696 58
Shanghai Weijiahe Biotechnology Co., Ltd 17502176150; 17502176150 861873257@qq.com China 2942 58
Shanghai Anbida Biotechnology Co., Ltd. 021-61629020 18201956406 sales@ambeed.cn China 7032 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 9972 58
Supplier Advantage
Chunchuang (Wuhan) Technology Co., Ltd 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
TargetMol Chemicals Inc. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58
Shanghai Weijiahe Biotechnology Co., Ltd 58
Shanghai Anbida Biotechnology Co., Ltd. 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Spectrum

Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-(2858800-98-1)1HNMR
OTUB1/USP8-IN-1 Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- OTUB1/USP8-IN-1, 10 mM in DMSO (R)-2-(2-Chloro-6-fluoro-3-((1-methylpyrrolidin-3-yl)oxy)phenyl)naphtho[2,3-d]oxazole-4,9-dione 2858800-98-1