Uses
Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].
in vivo
Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks) can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells[1].
| Animal Model: | BALB/c nude mice with HT-29 or Hce-8693 cells[1] |
| Dosage: | 10 or 15 mg/kg |
| Administration: | Intraperitoneal injection; twice a week; 5 weeks |
| Result: | Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model. |
| Animal Model: | BALB/c nude mice with CT-26 cells[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intramuscular injection; every second day; 10 times |
| Result: | Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%. |
References
[1] Y C Deng, et al. Activity of boanmycin against colorectal cancer. World J Gastroenterol. 2001 Feb;7(1):93-7. DOI:10.3748/wjg.v7.i1.93
[2] Hao Tang, et al. Effect of boanmycin on apoptosis and cell cycle of human esophageal cancer(Eca-109) cells]. Ai Zheng. 2002 Aug;21(8):855-9. PMID:12478892
[3] Peng Chen, et al. The chemotherapeutic drug boanmycin induces cell senescence and senescence-associated secretory phenotype factors, thus acquiring the potential to remodel the tumor microenvironment. Anticancer Drugs. 2016 Feb;27(2):84-8. DOI:10.1097/CAD.0000000000000304
