9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
- CAS No.
- 113852-41-8
- Chemical Name:
- 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
- Synonyms
- GS 0573;9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine;Phosphonic acid, P-[[2-(2,6-diamino-9H-purin-9-yl)ethoxy]methyl]-;sarcoma,replication,CMV,PMEDAP,Inhibitor,HIV,inhibit,mice,Human immunodeficiency virus,Cytomegalovirus,mortality,virus
- CBNumber:
- CB31316114
- Molecular Formula:
- C8H13N6O4P
- Molecular Weight:
- 288.2
- MDL Number:
- MOL File:
- 113852-41-8.mol
| Boiling point | 748.7±70.0 °C(Predicted) |
|---|---|
| Density | 2.03±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | 0.1 M NaOH : 14.29 mg/mL (49.58 mM; ultrasonic and adjust pH to 12 with NaOH) |
| form | Solid |
| pka | 2.37±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | 5EX1YUR4DH |
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine Chemical Properties,Uses,Production
Uses
PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality[1][2].
in vivo
PMEDAP (0.25-5 mg/kg; IP; daily; starting on the day of MSV-infected and continuing for an additional four days) causes a dose-dependent suppression of tumor formation and mortality in newborn mice inoculated with MSV[1].
| Animal Model: | Three-week-old male NMRI mice[1] |
| Dosage: | 0.25 mg/kg, 1 mg/kg, 5 mg/kg |
| Administration: | IP; daily; starting on the day of infection and continuing for an additional four days |
| Result: | Effected a significant delay in tumor appearance and an enhancement of the survival rate of tumor-bearing mice. |
References
[1] Neyts J, et al. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo [published correction appears in Eur J Clin Microbiol Infect Dis 1993 Jul;12(7):following 477]. Eur J Clin Microbiol Infect Dis. 1993;12(6):437-446. DOI:10.1007/BF01967438
[2] Naesens L, et al. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis. 1989;8(12):1043-1047. DOI:10.1007/BF01975167
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine Preparation Products And Raw materials
Raw materials
Preparation Products
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 | sales@sun-shinechem.com | China | 1042 | 64 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Wuhan Sun-shine Bio-technology Corporation Limited | +86-027-6552-2453 | sales@sun-shinechem.com | China | 727 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24863 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 55710 | 58 |