4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
- CAS No.
- 54757-47-0
- Chemical Name:
- 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
- Synonyms
- CHEMBRDG-BB 5229800;Acitretin Impurity 2;4-(4-Methoxy-2,3,6-trimethylphenyl);4-(4-Methoxy-2,3,6-trimethylphenyl)-3-en-2-one;4-(4-Methoxy-2,3,6-trimethyphenyl)-but-3-en-2-one;4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE;3-Buten-2-one, 4-(4-methoxy-2,3,6-trimethylphenyl)-;4-(4'-methoxy-2',3',6'-trimethylphenyl)-but-3-ene-2-one;(E)-4-(4-METHOXY-2,3,6-TRIMETHYL-PHENYL)-BUT-3-EN-2-ONE
- CBNumber:
- CB3132003
- Molecular Formula:
- C14H18O2
- Molecular Weight:
- 218.29
- MDL Number:
- MFCD00449197
- MOL File:
- 54757-47-0.mol
| Product description | Number | Pack Size | Price |
| 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one | M332495 | 50mg | $60 |
| 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one | 7959AB | 100mg | $29 |
| 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE 98.00% | CHM0165746 | 5G | $1443.75 |
| 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one | 54757470 | 5g | $189 |
| 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one 97% | CD12062298 | 10g | $277 |
| Melting point | 64-66 °C |
|---|---|
| Boiling point | 358.7±37.0 °C(Predicted) |
| Density | 1.006±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| InChI | InChI=1S/C14H18O2/c1-9-8-14(16-5)12(4)11(3)13(9)7-6-10(2)15/h6-8H,1-5H3 |
| InChIKey | NMRRLIHKRCVLLQ-UHFFFAOYSA-N |
| SMILES | CC(=O)C=CC1=C(C)C=C(OC)C(C)=C1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M332495 | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one | 54757-47-0 | 50mg | $60 | 2021-12-16 | Buy |
| AK Scientific | 7959AB | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one | 54757-47-0 | 100mg | $29 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0165746 | 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE 98.00% | 54757-47-0 | 5G | $1443.75 | 2021-12-16 | Buy |
| Alichem | 54757470 | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one | 54757-47-0 | 5g | $189 | 2021-12-16 | Buy |
| Crysdot | CD12062298 | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one 97% | 54757-47-0 | 10g | $277 | 2021-12-16 | Buy |
4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE Chemical Properties,Uses,Production
Uses
4-(4-Methoxy-2,3,6-trimethylphenyl)-3E-buten-2-one is a ketone derivative that can be used as a pharmaceutical intermediate.
Synthesis
54344-92-2
67-64-1
54757-47-0
General procedure for the synthesis of 4-(4-methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one from 4-methoxy-2,3,6-trimethylbenzaldehyde and acetone: Acetone (6000 mL) was added to 4-methoxy-2,3,6-trimethylbenzaldehyde (500.3 g) and the mixture was stirred at 20-30 °C. An aqueous sodium hydroxide solution (134.8 g NaOH dissolved in 500 mL of water) was added gradually and the reaction mixture was heated to 45-50 °C with continuous stirring. The progress of the reaction was monitored by HPLC and upon completion of the reaction, the reaction mixture was cooled and the pH was adjusted with acetic acid to 4.5-5.5. Subsequently, acetone was removed by distillation, cyclohexane was added to the residue, the organic layer was washed with water, the organic layer was separated and concentrated to afford the target product, 4-(4-methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one (Formula II). Yield: 80-84%.
References
[1] Pharmaceutical Research, 1995, vol. 12, # 7, p. 983 - 992
[2] Patent: WO2016/42573, 2016, A1. Location in patent: Page/Page column 8
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2010, vol. 185, # 3, p. 501 - 508
4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE Preparation Products And Raw materials
4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29827 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Chongqing Ensky Pharmaceutical Co.,Ltd. | +86-86-2386815286 +8613983794297 | sales@ensky-chemical.com | China | 93 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15080 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Wisdom Drugs Co .,Ltd | +86-0519-85556805 | Sales3@wisdomdrugs.com | China | 357 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9661 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
View Lastest Price from 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
54757-47-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-08-08 | 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
54757-47-0
|
US $3.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
54757-47-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
54757-47-0
- US $3.00 / KG
- 99%
- Career Henan Chemical Co
