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2-Hydroxy-4-quinolincarboxylic acid

2-Hydroxy-4-quinolincarboxylic acid Structure
2-Hydroxy-4-quinolincarboxylic acid structure
CAS No.
15733-89-8
Chemical Name:
2-Hydroxy-4-quinolincarboxylic acid
Synonyms
2-Hydroxy-4-quinolinecarboxylic acid;2-Oxo-1,2-dihydroquinoline-4-carboxylic acid;AKOS AUF0188;RARECHEM AQ NN 0221;IFLAB-BB F1918-0080;2-hydroxycinchoninic;4-carboxycarbostyril;Cinchocaine impurity B;Piraxostat Impurity 7;2-hydroxy-cinchoninicaci
CBNumber:
CB3132467
Molecular Formula:
C10H7NO3
Molecular Weight:
189.17
MDL Number:
MFCD00023942
MOL File:
15733-89-8.mol
MSDS File:
SDS
Last updated:2026-05-28 00:57:40
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2-Hydroxy-4-quinolincarboxylic acid Properties

Melting point 350°C
Boiling point 403.6±45.0 °C(Predicted)
Density 1.429±0.06 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
form Solid
pka 2.76±0.20(Predicted)
color Yellow to Dark Yellow
BRN 148331
InChI InChI=1S/C10H7NO3/c12-9-5-7(10(13)14)6-3-1-2-4-8(6)11-9/h1-5H,(H,11,12)(H,13,14)
InChIKey MFSHNFBQNVGXJX-UHFFFAOYSA-N
SMILES N1C2=C(C=CC=C2)C(C(O)=O)=CC1=O
LogP 0.3 at 25℃ and pH7
CAS DataBase Reference 15733-89-8(CAS DataBase Reference)
FDA UNII Z1Q2K479UQ
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36
WGK Germany  WGK 3
RTECS  GD3869000
HazardClass  IRRITANT
HS Code  29337900
Storage Class 13 - Non Combustible Solids
Toxicity mouse,LD,intraperitoneal,> 500mg/kg (500mg/kg),"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 338, 1953.
REACH Registrations Active
NFPA 704
0
2 0

2-Hydroxy-4-quinolincarboxylic acid price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS019980 2-Oxo-1,2-dihydroquinoline-4-carboxylic acid AldrichCPR 15733-89-8 100 mg $77.9 2026-04-30 Buy
TCI Chemical H1016 2-Hydroxyquinoline-4-carboxylic Acid >98.0%(HPLC)(T) 15733-89-8 5g $36 2026-04-30 Buy
TCI Chemical H1016 2-Hydroxyquinoline-4-carboxylic Acid >98.0%(HPLC)(T) 15733-89-8 25g $105 2026-04-30 Buy
Usbiological 279826 2-Hydroxyquinoline-4-carboxylic acid Asreported 15733-89-8 10g $333 2026-06-03 Buy
Usbiological 279826 2-Hydroxyquinoline-4-carboxylic acid Asreported 15733-89-8 25g $453 2026-06-03 Buy
Product number Packaging Price Buy
CDS019980 100 mg $77.9 Buy
H1016 5g $36 Buy
H1016 25g $105 Buy
279826 10g $333 Buy
279826 25g $453 Buy

2-Hydroxy-4-quinolincarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

Solid

Uses

1,2-Dihydro-2-oxo-4-quinolinecarboxylic Acid is a chemical constituent of vinegar Schisandra chinensis and is used as a indicator reagent in marking security documents.

Definition

ChEBI: 2-oxo-1,2-dihydroquinoline-4-carboxylic acid is a quinolinemonocarboxylic acid. It is a conjugate acid of a 2-oxo-1,2-dihydroquinoline-4-carboxylate.

Synthesis

Malonic acid

141-82-2

Isatin

91-56-5

2-Hydroxy-4-quinolincarboxylic acid

15733-89-8

1. Add 400kg of recovered glacial acetic acid to the 1000L reactor and start stirring. 2. 100kg of indigo, 160kg of malonic acid and 15kg of sodium acetate were added sequentially to the reactor to ensure adequate mixing. 3. The reaction mixture was heated to reflux and the reflux reaction was maintained for 6 hours. 4. Upon completion of the reaction, the acetic acid was removed by distillation under reduced pressure. 5. 300 kg of deionized water was added to the reaction mixture and stirred to promote crystal formation. 6. 6. The solid product was collected by filtration, washed with 30 kg of cold glacial acetic acid, and then rinsed with 30 kg of cold methanol to obtain the wet product of 2-quinolinone-4-carboxylic acid. 7. The wet product was dried at 45-70 °C for 24 h. 125 kg of 2-quinolinone-4-carboxylic acid was finally obtained with a yield of 97.3% and a liquid phase purity of 99.6%.

References

[1] Patent: CN108101842, 2018, A. Location in patent: Paragraph 0021; 0023
[2] Synthetic Communications, 2005, vol. 35, # 17, p. 2243 - 2250
[3] Patent: WO2013/153357, 2013, A1. Location in patent: Page/Page column 44
[4] Patent: US2015/45354, 2015, A1. Location in patent: Paragraph 0271-0274
[5] Chemische Berichte, 1914, vol. 47, p. 358

2-Hydroxy-4-quinolincarboxylic acid Preparation Products And Raw materials

Raw materials

Malonic acid Isatin

Preparation Products

2-Chloroquinoline-4-carboxylic acid Quinoline-4-carboxylic acid 1-Methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid 4-Quinolinecarboxylic acid, 2-chloro-, ethyl ester

2-Hydroxy-4-quinolincarboxylic acid Suppliers

Global( 317)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangxi Kingnord Industrial Limited 0791-86493591 jeff@kingnord.com China 43 57
SHENZHEN REISCH BIOTECH CO., LTD 0755-0755-28609002 15112530219 1179151648@qq.com China 236 58
Suzhou dexuan New Material Technology Co., Ltd 13773006286;13706249848 siyzhxl@163.com China 29 58
Shanghai Jiezhen Pharmaceutical Technology Co., Ltd. 15995055116 815229059@qq.com China 166 58
Jiangxi Jingyang Chemical Products Co., LTD 0798-15170312128 15170312128 1436027029@qq.com China 16 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Supplier Advantage
Jiangxi Kingnord Industrial Limited 57
SHENZHEN REISCH BIOTECH CO., LTD 58
Suzhou dexuan New Material Technology Co., Ltd 58
Shanghai Jiezhen Pharmaceutical Technology Co., Ltd. 58
Jiangxi Jingyang Chemical Products Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56

View Lastest Price from 2-Hydroxy-4-quinolincarboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Hydroxy-4-quinolincarboxylic acid pictures 2026-08-20 2-Hydroxy-4-quinolincarboxylic acid
15733-89-8
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
2-Hydroxy-4-quinolincarboxylic acid pictures 2025-04-04 2-Hydroxy-4-quinolincarboxylic acid
15733-89-8
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Hydroxy-4-quinolincarboxylic acid pictures 2024-01-18 2-Hydroxy-4-quinolincarboxylic acid
15733-89-8
 $88.00 1KG 99% 100000T Xiamen Wonderful Bio Technology Co., Ltd.

2-Hydroxy-4-quinolincarboxylic acid Spectrum

2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)MS2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)1HNMR2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)13CNMR2-Hydroxy-4-quinolincarboxylic acid(15733-89-8)IR12-Hydroxy-4-quinolincarboxylic acid(15733-89-8)IR2

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IFLAB-BB F1918-0080 AKOS AUF0188 1,2-DIHYDRO-2-OXOQUINOLINE-4-CARBOXYLIC ACID 2-HYDROXY-4-QUINOLINCARBOXYLIC ACID 2-HYDROXYCINCHONINIC ACID RARECHEM AQ NN 0221 1,2-dihydro-2-oxo-4-quinolinecarboxylicaci 2-hydroxy-cinchoninicaci 4-carboxycarbostyril 2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID 98% 2-hydroxycinchoninic 2-Hydroxyquinoline-4-carboxylic acid hydrate, 98+% ##USE H29247## 2-Hydroxyquinoline-4-carboxylic acid hydrate, 98+% 4-quinolinecarboxylic acid, 2-hydroxy- 2-Hydroxyquinoline-4-carboxylic acid, 98+% 2-oxo-1,2-dihydroquinoline-4-carboxylic acid(SALTDATA: 0.7H2O) 2-oxo-1,2-dihydroquinoline-4-carboxylic acid 0.7H2O 2-Hydroxyquinolin-4-carboxylic acid 1,2-Dihydro-2-oxoquinoline-4-carboxylic Acid 2-Hydroxycinchoninic Acid 2-oxo-4-quinolinecarboxylic acid 1,2-Dihydro-2-oxo-quinolin-4-carboxylic acid Methyl 2-hydroxyquinoline-4-carboxylate 1,2-Dihydro-2-oxo-4-quinolinecarboxylic acid 4-Quinolinecarboxylicacid, 1,2-dihydro-2-oxo- Cinchocaine EP Impurity B 1,2-Dihydro-2-oxo-4-Cinchocaine EP Impurity B Cinchocaine impurity B 2-Hydroxyquinoline-4-carboxylicAcid> Cinchocaine EP Impurity B (2-Hydroxyquinoline-4-Carboxylic Acid) 1,2-Dihydro-2-Oxoquinoline-4-CarboxylicAci 2-Hydroxy-4-quinolincarboxylic acid ISO 9001：2015 REACH Cinchocaine Hydrochloride Impurity B Cinchocaine Hydrochloride EP Impurity B Piraxostat Impurity 7 Cinchocaine Hydrochloride Imp. B (EP): 2-Hydroxyquinoline-4- Cinchocaine impurity B【Y0002032】 2-Hydroxy-4-quinolinecarboxylic acid 2-Oxo-1,2-dihydroquinoline-4-carboxylic acid 15733-89-8 Hydroxyquinolines Quinolines Building Blocks Heterocyclic Building Blocks Hydroxyquinolines Quinolines Intermediate