2-Chloroquinoline-4-carboxylic acid
- CAS No.
- 5467-57-2
- Chemical Name:
- 2-Chloroquinoline-4-carboxylic acid
- Synonyms
- Nsc25654;AKOS BB-6908;2-Chlorocinchoninic acid;A-CHLORO CINCHONINIC ACID;2-CHLORO-4-CARBOXY QUINOLINE;2-Chloroquinoline-4-CarboxylicAci;2-Chloro-4-quinolinecarboxylic acid;2-Chloroquinoline-4-carboxylic acid;4-Quinolinecarboxylic acid, 2-chloro-;2-Chloroquinoline-4-carboxylic Acid >
- CBNumber:
- CB6208905
- Molecular Formula:
- C10H6ClNO2
- Molecular Weight:
- 207.61
- MDL Number:
- MFCD00023940
- MOL File:
- 5467-57-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 244 °C |
|---|---|
| Boiling point | 368.7±22.0 °C(Predicted) |
| Density | 1.469±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 2.17±0.10(Predicted) |
| color | White to Orange to Green |
| InChI | InChI=1S/C10H6ClNO2/c11-9-5-7(10(13)14)6-3-1-2-4-8(6)12-9/h1-5H,(H,13,14) |
| InChIKey | ICNCOMYUODLTAI-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=CC=2)C(C(O)=O)=CC=1Cl |
| CAS DataBase Reference | 5467-57-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36/37/39 |
| HazardClass | IRRITANT |
| HS Code | 2933491090 |
2-Chloroquinoline-4-carboxylic acid price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1703 | 2-Chloroquinoline-4-carboxylic Acid >97.0%(HPLC)(T) | 5467-57-2 | 5g | $151 | 2026-04-30 | Buy |
| TCI Chemical | C1703 | 2-Chloroquinoline-4-carboxylic Acid >97.0%(HPLC)(T) | 5467-57-2 | 25g | $556 | 2026-04-30 | Buy |
| Usbiological | 417236 | 2-Chloroquinoline-4-carboxylic Acid | 5467-57-2 | 1g | $340 | 2026-06-03 | Buy |
| Usbiological | 417236 | 2-Chloroquinoline-4-carboxylic Acid | 5467-57-2 | 5g | $538 | 2026-06-03 | Buy |
| Usbiological | 230237 | 2-Chloroquinoline-4-carboxylic acid ≥95% (NMR) ≥95%(NMR) | 5467-57-2 | 1g | $215 | 2026-06-03 | Buy |
2-Chloroquinoline-4-carboxylic acid Chemical Properties,Uses,Production
Uses
2-Chloroquinoline-4-carboxylic Acid is an intermediate used to prepare dimethyl(naphthalenecarbonyl)aminobenzoic acids as potent and selective EP4 antagonists.
Synthesis
15733-89-8
5467-57-2
The general procedure for the synthesis of 2-chloroquinoline-4-carboxylic acid from 2-quinolone-4-carboxylic acid was as follows: 2-hydroxyquinoline-4-carboxylic acid (2.57 g, 13.6 mmol) was mixed with phosphorus oxytriphosphate (POCl3, 25 mL) and heated and refluxed for 24 hours. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into crushed ice (300 g). The precipitated solid was separated by filtration, washed thoroughly with deionized water and dried under high vacuum to give 2.47 g of white solid product in 87% yield. The product was characterized by 1H NMR (CDCl3, 300 MHz) and LCMS: 1H NMR δ 8.67 (d, 1H, J = 8.4 Hz), 7.91 (d, 1H, J = 8.1 Hz), 7.83 (s, 1H), 7.67 (t, 1H, J = 7.2 Hz), 7.54 (t, 1H, J = 7.2 Hz); LCMS (m/ z): 208 ([M+H]+).
References
[1] Patent: WO2005/30774, 2005, A1. Location in patent: Page/Page column 23
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1837,1838
[3] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1938, vol. 125, p. 60,69
2-Chloroquinoline-4-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHENZHEN REISCH BIOTECH CO., LTD | 0755-0755-28609002 15112530219 | 1179151648@qq.com | China | 236 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
View Lastest Price from 2-Chloroquinoline-4-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
5467-57-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2021-10-16 | 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
5467-57-2
|
$10.00 | 1KG | 99% | 20 tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2019-12-23 | 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
5467-57-2
|
$1.00 | 1KG | 85.0-99.8% | 20ton | Career Henan Chemical Co |
-
- 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
5467-57-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
5467-57-2
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
5467-57-2
- $1.00
- 85.0-99.8%
- Career Henan Chemical Co
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