GGTI-2154 hydrochloride
- CAS No.
- 478908-50-8
- Chemical Name:
- GGTI-2154 hydrochloride
- Synonyms
- GGTI-2154 hydrochloride;L-Leucine, N-[[5-[(1H-imidazol-4-ylmethyl)amino]-2′-methyl[1,1′-biphenyl]-2-yl]carbonyl]-, monohydrochloride
- CBNumber:
- CB313259795
- Molecular Formula:
- Molecular Weight:
- 456.97
- MDL Number:
- MOL File:
- 478908-50-8.mol
- MSDS File:
- SDS
GGTI-2154 hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0173740 | GGTI-2154 hydrochloride 98.08% | 478908-50-8 | 5mg | $672 | 2026-06-04 | Buy |
| ChemScene | CS-0173740 | GGTI-2154 hydrochloride 98.08% | 478908-50-8 | 10mg | $1062 | 2026-06-04 | Buy |
| ChemScene | CS-0173740 | GGTI-2154 hydrochloride 98.08% | 478908-50-8 | 25mg | $2112 | 2026-06-04 | Buy |
| ChemScene | CS-0173740 | GGTI-2154 hydrochloride 98.08% | 478908-50-8 | 50mg | $3521 | 2026-06-04 | Buy |
| ChemScene | CS-0173740 | GGTI-2154 hydrochloride 98.08% | 478908-50-8 | 100mg | $5633 | 2026-06-04 | Buy |
GGTI-2154 hydrochloride Chemical Properties,Uses,Production
Uses
GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer[1][2].
in vivo
GGTI-2154 (100 mg/kg/day; s.c. for 14 days) induces breast tumor regression in MMTV-ν-Ha-Ras transgenic mice[2].
GGTI-2154 (50 mg/kg/day; i.p. for 50 day) inhibits A-549 tumor growth in nude mice by 60%[1].
| Animal Model: | MMTV-v-Ha-ras transgenic mice bearing mammary carcinoma[2] |
| Dosage: | 100 mg/kg/day |
| Administration: | S.c. with osmotic mini-pumps for 14 days |
| Result: | Halted the tumors aggressive growth. Resulted in rapid tumor regression within 3 days of initiation of drug treatment. |
References
[1] Sun J, et, al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26. PMID:10519405
[2] Sun J, et, al. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. Cancer Res. 2003 Dec 15;63(24):8922-9. PMID:14695209
GGTI-2154 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
GGTI-2154 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| Guangzhou Younan Technology Co., Ltd | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
View Lastest Price from GGTI-2154 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | GGTI-2154 hydrochloride
478908-50-8
|
$1980.00-2690.00 | 10g | TargetMol Chemicals Inc. |
-
- GGTI-2154 hydrochloride
478908-50-8
- $1980.00-2690.00
- TargetMol Chemicals Inc.
