5-benzylacyclouridine
- CAS No.
- 82857-69-0
- Chemical Name:
- 5-benzylacyclouridine
- Synonyms
- Benzylacyclouridine;5-benzylacyclouridine;5-Benzyl-1-(2-hydroxyethoxymethyl)uracil;6-Benzyl-1-(2-hydroxy ethoxymethyl)uracil;2,4(1H,3H)-Pyrimidinedione, 1-[(2-hydroxyethoxy)methyl]-5-(phenylmethyl)-
- CBNumber:
- CB31334015
- Molecular Formula:
- C14H16N2O4
- Molecular Weight:
- 276.29
- MDL Number:
- MFCD00866330
- MOL File:
- 82857-69-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 144-145 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Density | 1.290±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (361.94 mM; Need ultrasonic) |
| pka | 9.43±0.10(Predicted) |
| form | Solid |
| color | White to light yellow |
| FDA UNII | 0H851I3O9D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H315-H302 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P |
5-benzylacyclouridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FB139099 | 5-Benzyl-1-(2-hydroxyethoxymethyl)uracil | 82857-69-0 | 1mg | $362.8 | 2026-06-04 | Buy |
| Biosynth | FB139099 | 5-Benzyl-1-(2-hydroxyethoxymethyl)uracil | 82857-69-0 | 2mg | $453.52 | 2026-06-04 | Buy |
| Biosynth | FB139099 | 5-Benzyl-1-(2-hydroxyethoxymethyl)uracil | 82857-69-0 | 5mg | $580.5 | 2026-06-04 | Buy |
| Biosynth | FB139099 | 5-Benzyl-1-(2-hydroxyethoxymethyl)uracil | 82857-69-0 | 10mg | $725.6 | 2026-06-04 | Buy |
| Biosynth | FB139099 | 5-Benzyl-1-(2-hydroxyethoxymethyl)uracil | 82857-69-0 | 25mg | $1088.25 | 2026-06-04 | Buy |
5-benzylacyclouridine Chemical Properties, Uses, Production
Uses
Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives[1][2][3].
Definition
ChEBI: A pyrimidone that is uracil which is substituted by a 2-hydroxyethoxymethyl group at position 1 and a benzyl group at position 5.
in vivo
Benzylacyclouridine (p.o. or i.v.) arrests the rapid degradation of a tracer dose of uridine into uracil in dogs and pigs[1].
Benzylacyclouridine exhibits the t1/2 of 1.8-3.6 h in dogs, with bioavailability levels of 85% (30 mg/kg) and 42.5% (120 mg/kg)[1].
Benzylacyclouridine (120 mg/kg) exhibits the t1/2 of 1.6-2.3 h, with a bioavailability of 40% in pigs[1].
References
[1] Pizzorno G, et, al. Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor. Clin Cancer Res. 1998 May;4(5):1165-75. PMID:9607574
[2] Monks A, et, al. Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver. Biochem Pharmacol. 1983 Jul 1;32(13):2003-9. DOI:10.1016/0006-2952(83)90419-7
[3] Roosild TP, et, al. Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. BMC Struct Biol. 2009 Mar 16;9:14. DOI:10.1186/1472-6807-9-14
5-benzylacyclouridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-benzylacyclouridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3307 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29089 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Panaishen (Henan) Pharmaceutical Science and Technology Co. , Ltd. | 0371-65325800 13700860222 | haifeng.zhang@pannacean.com | China | 1703 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9755 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
View Latest Price from 5-benzylacyclouridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Benzylacyclouridine
82857-69-0
|
$152.00 | 98.18% | 10g | TargetMol Chemicals Inc. |
-
- Benzylacyclouridine
82857-69-0
- $152.00
- 98.18%
- TargetMol Chemicals Inc.
