N-Acetyl-D-Glucosamine
- CAS No.
- 7512-17-6
- Chemical Name:
- N-Acetyl-D-Glucosamine
- Synonyms
- N-ACETYLGLUCOSAMINE;acetylglucosamine;D-GLCNAC;2-ACETAMIDO-2-DEOXY-D-GLUCOSE;2-Acetamido-2-deoxy-D-glucopyranose;N-Acetyl-D-glucosamin;N-Acetyl-beta-D-glucosamine;NADG;Acetyl chitin;2-Acetamido-D-glucose
- CBNumber:
- CB0320700
- Molecular Formula:
- C8H15NO6
- Molecular Weight:
- 221.21
- MDL Number:
- MFCD00136044
- MOL File:
- 7512-17-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-Acetyl-D-glucosamine suitable for cell culture, BioReagent | A3286 | 5g | $39.6 |
| N-Acetyl-D-glucosamine United States Pharmacopeia (USP) Reference Standard | 1010022 | 200mg | $402 |
| N-Acetyl-D-glucosamine >98.0%(HPLC)(N) | A0092 | 25g | $38 |
| N-Acetyl-D-glucosamine >98.0%(HPLC)(N) | A0092 | 100g | $109 |
| N-acetyl-D-Glucosamine ≥98% | 13136 | 500mg | $16 |
| More product size | |||
| Melting point | 211 °C (dec.) (lit.) |
|---|---|
| alpha | 42 º (c=2,water,2 hrs) |
| vapor pressure | 8Pa at 20℃ |
| refractive index | +39.0 to +42.0 ° (C=1, H2O) |
| storage temp. | -20°C |
| solubility | Soluble in concentrated hydrochloric acid, sulfuric acid, phosphoric acid and formic acid. Insoluble in water, dilute acids, dilute alkalis, concentrated alkalis and organic solvents. |
| form | saline suspension |
| Boiling point | 636.4±55.0 °C(Predicted) |
| Density | 1.54 g/cm3 |
| pka | 13.04±0.20(Predicted) |
| color | white to off-white |
| biological source | crab (red) |
| optical activity | Alpha type +75 → +41 Beta type -22 → +41.3 |
| Water Solubility | H2O: 50 mg/mL colorless to faint yellow solution, clear to very slightly hazy |
| Sensitive | Hygroscopic |
| Merck | 14,4458 |
| BRN | 1727589 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Cosmetic Ingredient Review (CIR) | N-Acetyl-D-Glucosamine (7512-17-6) |
| InChI | 1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8/m1/s1 |
| InChIKey | OVRNDRQMDRJTHS-ROGOILFBSA-N |
| SMILES | CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O |
| LogP | -2.2 at 23.7℃ |
| CAS DataBase Reference | 7512-17-6(CAS DataBase Reference) |
| FDA UNII | V956696549 |
| EPA Substance Registry System | N-Acetylglucosamine (7512-17-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.75 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LZ6651000 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29329985 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
N-Acetyl-D-Glucosamine price More Price(135)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A3286 | N-Acetyl-D-glucosamine suitable for cell culture, BioReagent | 7512-17-6 | 5g | $39.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1010022 | N-Acetyl-D-glucosamine United States Pharmacopeia (USP) Reference Standard | 7512-17-6 | 200mg | $402 | 2026-04-30 | Buy |
| TCI Chemical | A0092 | N-Acetyl-D-glucosamine >98.0%(HPLC)(N) | 7512-17-6 | 25g | $38 | 2026-04-30 | Buy |
| TCI Chemical | A0092 | N-Acetyl-D-glucosamine >98.0%(HPLC)(N) | 7512-17-6 | 100g | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 13136 | N-acetyl-D-Glucosamine ≥98% | 7512-17-6 | 500mg | $16 | 2026-04-30 | Buy |
N-Acetyl-D-Glucosamine Chemical Properties,Uses,Production
Description
N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate.
N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Chemical Properties
White powder
Uses
N-Acetyl-D-glucosamine is used in the identification and characterization of N-acetyl-beta-D-hexoaminidase. It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Uses
N-acetyl-D-Glucosamine (GlcNAc) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc.D-GlcNAc enhances the proliferation and collagen expression of fibroblasts, reduces hyperpigmentation and is therefore considered a valuable ingredient in cosmetics for improving skin wrinkles and color.Important substrate for the production of sialic acids.Used in multiple other applications in drug development and food supplement, based on a newly described bio-wave model.
Definition
ChEBI: N-acetyl-D-glucosamine is the D isomer of N-acetylglucosamine. It has a role as a bacterial metabolite. It is a N-acetylglucosamine and a N-acetyl-D-hexosamine.
General Description
N-Acetyl-D-glucosamine (GlcNAc) is a monosaccharide, derived from glucose and undergoes linear polymerization by (1,4)-β-linkages to form the polymer chitin. It is also a component of heterogenous polysaccharides, such as murein and hyaluronic acid. N-acetylglucosamine exhibits anti-inflammatory properties and is considered as a potential drug in the treatment of osteoarthritis. Its antiarthritic mode of mechanism involves the suppression of IL-1β (Interleuken-1β)-induced NO (nitric oxide), cyclooxygenase-2 (COX-2), and IL-6 production by inhibition of expression of iNOS (inducible nitric oxide synthase) protein and mRNA.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
N-Acetyl-D-glucosamine (GlcNAc) oligomer may have the ability to initiate factors for canine polymorphonuclear cells (PMN) in vivo. It possesses wound healing and chemotactic activity. GlcNAc and its derivatives are usually employed in preparing dietary supplements and also used in therapeutic development.
Synthesis
a. Dissolve D-glucosamine hydrochloride and ethanol in water at a mass ratio of 2 to 2.5:100, and adjust the pH of the solution to 9 to 10; b. Filter, take the filtrate, add acetic anhydride under stirring, the amount added is 50~60wt% of the amount of raw material D-glucosamine hydrochloride;
c. After stirring the reaction for 2 hours, recrystallize with anhydrous ethanol; d. Filtering, the crystals were recrystallized with water again to get the rod-shaped food-grade N-acetylglucosamine.Research
Yang Yang and colleagues reported a pivotal role for N-acetyl-D-glucosamine (GlcNAc) in modulating parasite-induced inflammation. Exogenous administration of GlcNAc to T. gondii-infected mice resulted in the marked downregulation of key pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IL-12, and a significant upregulation of the anti-inflammatory cytokines IL-10 and TGF-β.[1]
References
[1] Yang, Y., Zhou, C., Yang, C., Yang, Z., Xu, S., Ma, X., Sun, S., & Yang, J. (2026). Gut microbiota-associated metabolite N-acetyl-D-glucosamine alleviates systemic inflammatory responses induced by acute Toxoplasma gondii infection. PLoS Neglected Tropical Diseases, 20 3, e0014108. https://doi.org/10.1371/journal.pntd.0014108
N-Acetyl-D-Glucosamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lotusland Life Sciences | +8615821988213 | info@longyupharma.com | China | 2411 | 58 |
| Huzhou Chenxi Environmental Protection Technology Co. , Ltd. | +86-16762203950 | 1034385273@qq.com | China | 55 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 | sales01@watsonbiotech.cn | China | 5731 | 58 |
| Nantong Provichem Biotech Co., Ltd. | +8617505220108 | sales@provichem.cn | China | 97 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-17392712779 | 1097@dideu.com | China | 3989 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5216 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8046 | 58 |
| Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 | sales1@hbganmiao.com | China | 217 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2452 | 58 |
Related articles
- N-Acetyl-D-glucosamine: used for the treatment of Osteoarthritis
- N-Acetyl-D-glucosamine, or glcnac or N-acetylchitosamine, belongs to the class of organic compounds known as acylaminosugars.
- Jul 25，2024
- Functions of N-acetyl glucosamine
- N-acetyl glucosamine (NAG) is a newer pigment reduction agent. It is an amino-monosaccharide produced in the body by adding an....
- Mar 4，2022
View Lastest Price from N-Acetyl-D-Glucosamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-14 | Acetyl chitin | 1kg | 99% | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-14 | N-Acetyl-D-Glucosamine
7512-17-6
|
1kg | 99% | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-13 | N-Acetyl-D-Glucosamine
7512-17-6
|
0.99 | RongNa Biotechnology Co.,Ltd |
-
- Acetyl chitin
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- N-Acetyl-D-Glucosamine
7512-17-6
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- N-Acetyl-D-Glucosamine
7512-17-6
- 0.99
- RongNa Biotechnology Co.,Ltd
