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annonacin
- CAS No.
- 111035-65-5
- Chemical Name:
- annonacin
- Synonyms
- annonacin;(+/-) Annonacin (Mixture of Isomers);(5S)-5-Methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[[(2R)-tetrahydro-5α-[(R)-1-hydroxytridecyl]furan]-2β-yl]tridecyl]-2(5H)-furanone;2(5H)-Furanone, 5-methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]tridecyl]-, (5S)-
- CBNumber:
- CB31344614
- Molecular Formula:
- C35H64O7
- Molecular Weight:
- 596.88
- MDL Number:
- MFCD27664980
- MOL File:
- 111035-65-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-08-02 18:55:13
| Melting point | 69-71 °C |
|---|---|
| Boiling point | 756.2±55.0 °C(Predicted) |
| Density | 1.050±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml |
| form | A powder |
| pka | 14.45±0.20(Predicted) |
| color | White to off-white |
| InChIKey | XNODZYPOIPVPRF-CGWDHHCXSA-N |
| SMILES | O1[C@@H](C)C=C(C[C@H](O)CCCCC[C@@H](O)CCCC[C@@H](O)[C@H]2CC[C@H]([C@H](O)CCCCCCCCCCCC)O2)C1=O |
| FDA UNII | 40372ET6TM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
annonacin price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22415 | Annonacin ≥90% | 16622941-85-8 | 500μg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 22415 | Annonacin ≥90% | 16622941-85-8 | 1mg | $268 | 2026-04-30 | Buy |
| Usbiological | 379593 | Annonacin ≥98% | 111035-65-5 | 5mg | $739 | 2026-06-03 | Buy |
| ChemScene | CS-0023456 | Annonacin 98.09% | 111035-65-5 | 1mg | $314 | 2026-06-04 | Buy |
| ChemScene | CS-0023456 | Annonacin 98.09% | 111035-65-5 | 5mg | $785 | 2026-06-04 | Buy |
annonacin Chemical Properties, Uses, Production
Uses
(+/-) Annonacin is used as a modulation of cancer signaling pathway(s) in two -stage mouse skin tumorigenesis by annonacin. Its also used in the evaluation of nutritional characteristics and bioactive compounds of Annona muricata-yogurt and Annona muricata-frozen dessert.
in vivo
Annonacin (0-9 mg/kg; Subcutaneous osmotic pump; 3 days) increases tau phosphorylation in R406W+/+ mice [3].
Annonacin (85 nM/100 μL; Topical application; Twice a week for 22 weeks) has anti-cancer effect in mouse model of skin tumor [4].
| Animal Model: | R406W+/+ transgenic mice[3] |
| Dosage: | 0, 6 and 9 mg/kg/day |
| Administration: | Subcutaneous osmotic pump; 3 days |
| Result: | Increased the number of neurons with phosphorylated tau in the somatodendritic compartment in several brain areas. Increased the levels of phosphorylated tau protein. Increased in total tau protein without increase in tau mRNA, but reduced proteasomal proteolytic activity. Increased the levels of different tau kinases. Significantly increased the ratio of p25/p35. |
| Animal Model: | DMBA (HY-W011845)/TPA treated female ICR mice aged 6-7 weeks old[4] |
| Dosage: | 85 nM/100 uL |
| Administration: | Topical application; Twice a week for 22 weeks |
| Result: | Significantly increased the tumor latency period and reduced the tumor incidence, tumor burden and tumor volume, respectively. Suppressed tumorigenesis manifested by significant reduction of hyperkeratosis, dermal papillae and number of keratin pearls on skin tissues. Showed no toxicity to the liver and kidneys. |
annonacin Preparation Products And Raw materials
Raw materials
Preparation Products
annonacin Suppliers
Global Suppliers ( 88)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Sichuan BioCrick Biotech Co., Ltd | 28-86-28-8543-3893 13260669172 | sales@biocrick.com | China | 5020 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| ALB Technology Limited | 702-983-3769 | sales@albtechnology.com | United States | 2992 | 55 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
111035-65-5 (annonacin) Related Search:
annonacin
(5S)-5-Methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[[(2R)-tetrahydro-5α-[(R)-1-hydroxytridecyl]furan]-2β-yl]tridecyl]-2(5H)-furanone
2(5H)-Furanone, 5-methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]tridecyl]-, (5S)-
(+/-) Annonacin (Mixture of Isomers)
111035-65-5
Csub35subHsub64subOsub7sub
