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ChemicalBook >> CAS DataBase List >>5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine

5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine

5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine Structure
5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine structure
CAS No.
2847881-42-7
Chemical Name:
5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine
Synonyms
TH-Z816;5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine
CBNumber:
CB313477492
Molecular Formula:
C29H38N6O
Molecular Weight:
486.65
MDL Number:
MOL File:
2847881-42-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:44
Request For Quotation

5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine Properties

Boiling point 709.2±70.0 °C(Predicted)
Density 1.168±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka 9.32±0.40(Predicted)

5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0834184 TH-Z816 2847881-42-7 1mg $99 2026-06-04 Buy
ChemScene CS-0834184 TH-Z816 2847881-42-7 5mg $297 2026-06-04 Buy
ChemScene CS-0834184 TH-Z816 2847881-42-7 10mg $431 2026-06-04 Buy
ChemScene CS-0834184 TH-Z816 2847881-42-7 25mg $714 2026-06-04 Buy
Arctom HY-153662 TH-Z816 2847881-42-7 1mg $87 2026-05-26 Buy
Product number Packaging Price Buy
CS-0834184 1mg $99 Buy
CS-0834184 5mg $297 Buy
CS-0834184 10mg $431 Buy
CS-0834184 25mg $714 Buy
HY-153662 1mg $87 Buy

5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine Chemical Properties, Uses, Production

Uses

TH-Z816 is a reversible inhibitor againstKRAS(G12D)mutation with an IC50 value of 14 μM, which can be used in cancer research[1].

References

[1] Zhongwei Mao, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5. DOI:10.1038/s41421-021-00368-w

5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine Suppliers

Global Suppliers ( 11)
Supplier Tel Email Country ProdList Advantage
Chengdu Novel Biomedical Co., Ltd. 028-85255396 18302801538 cdnovell@163.com China 2444 58
Changzhou Yongfeng Biomedicine Co. Ltd. 15006117673 2973592490@qq.com China 270 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9867 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 7283 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Olix ( Hubei) Pharmaceutical Technology Co., Ltd 17316404525 17316404525 209533805@qq.com China 9769 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 9998 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD +86-13382787392 sales@aeechem.com China 10001 58
Wuhan Jingkang en Biomedical Technology Co., Ltd +86-0086-13720134139 orders@jknbiochem.com China 5215 58
Supplier Advantage
Chengdu Novel Biomedical Co., Ltd. 58
Changzhou Yongfeng Biomedicine Co. Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 58
Nantong QuanYi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Olix ( Hubei) Pharmaceutical Technology Co., Ltd 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58

2847881-42-7 (5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine) Related Search:

2,7-Diazaspiro[4.4]nonane-2-acetamide, α-cyclopentyl-7-[[(2R,3R)-3-cyclopropyl-1-methyl-2-aziridinyl]carbonyl]-N-[(1R,10S,12S,18S)-1-[5-(4-cyclopropyl-1-piperazinyl)-2-[(1S)-1-methoxyethyl]-3-pyridinyl]-2,7,8,10,11,12,13,16,17,18,19,21,22,23-tetradecahydro-22,22-dimethyl-13,19-dioxo-2-(2,2,2-trifluoroethyl)-15H-3,5-etheno-14,18-imino-6,10-methano-6H-pyrrolo[3,4-g][1,12,4,18]dioxadiazacyclodocosin-12-yl]-, (αS,5S)- NAV2729 Y-27632 RMC6291 RMC-7977
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5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine TH-Z816 2847881-42-7