GEM231
- CAS No.
- 255810-66-3
- Chemical Name:
- GEM231
- Synonyms
- GEM231
- CBNumber:
- CB31361381
- Molecular Formula:
- C173H223N61O111P18S18
- Molecular Weight:
- 6067.7
- MDL Number:
- MFCD09837867
- MOL File:
- 255810-66-3.mol
| NCI Dictionary of Cancer Terms | GEM 231 |
|---|
GEM231 Chemical Properties,Uses,Production
Uses
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
References
[1] Agrawal S, Kandimalla ER, Yu D, et al. GEM 231, a second-generation antisense agent complementary to protein kinase A RIalpha subunit, potentiates antitumor activity of irinotecan in human colon, pancreas, prostate and lung cancer xenografts. Int J Oncol. 2002;21(1):65-72. PMID:12063551
[2] Mani S, Goel S, Nesterova M, et al. Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I. Ann N Y Acad Sci. 2003;1002:252-262. DOI:10.1196/annals.1281.028
[3] Wang H, Hang J, Shi Z, et al. Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity. Int J Oncol. 2002;21(1):73-80. PMID:12063552