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1-(2-Chloroethoxy)-4-nitrobenzene

CAS No.
3383-72-0
Chemical Name:
1-(2-Chloroethoxy)-4-nitrobenzene
Synonyms
β-chloro-4-nitrophenethole;BETA-CHLORO-4-NITROPHENETHOLE;4-(2-Chloroethoxy)nitrobenzene;2-(4-NITROPHENOXY)ETHYL CHLORIDE;4-Nitro-1-(2-chloroethoxy)benzene;1-(2-CHLOROETHOXY)-4-NITROBENZENE;2-CHLOROETHYL-4-NITROPHENYL ETHER;Benzene, 1-(2-chloroethoxy)-4-nitro-;1-(2-Chloroethoxy)-4-nitrobenzene,97%;1-(2-CHLOROETHOXY)4-NITROBENZENE, 98+%
CBNumber:
CB3136632
Molecular Formula:
C8H8ClNO3
Molecular Weight:
201.61
MDL Number:
MFCD00674505
MOL File:
3383-72-0.mol
MSDS File:
SDS
Last updated:2026-05-28 00:57:28
Product description Number Pack Size Price
1-(2-Chloroethoxy)-4-nitrobenzene >98.0%(GC) C3523 1g $80
1-(2-Chloroethoxy)-4-nitrobenzene >98.0%(GC) C3523 5g $240
1-(2-Chloroethoxy)-4-nitrobenzene Asreported 269193 1g $396
1-(2-Chloroethoxy)-4-nitrobenzene Asreported 269193 2g $623
1-(2-Chloroethoxy)-4-nitrobenzene Asreported 269193 5g $941
More product size

1-(2-Chloroethoxy)-4-nitrobenzene Properties

Melting point 67-68 °C
Boiling point 204-206 °C(Press: 25 Torr)
Density 1.316±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
color White to Light yellow
InChI InChI=1S/C8H8ClNO3/c9-5-6-13-8-3-1-7(2-4-8)10(11)12/h1-4H,5-6H2
InChIKey OBCFOPGCTNULTG-UHFFFAOYSA-N
SMILES C1(OCCCl)=CC=C([N+]([O-])=O)C=C1
CAS DataBase Reference 3383-72-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H335-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
9-21
HazardClass  IRRITANT
HS Code  2909309090
REACH Registrations Inactive
NFPA 704
0
2 0

1-(2-Chloroethoxy)-4-nitrobenzene price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C3523 1-(2-Chloroethoxy)-4-nitrobenzene >98.0%(GC) 3383-72-0 1g $80 2026-04-30 Buy
TCI Chemical C3523 1-(2-Chloroethoxy)-4-nitrobenzene >98.0%(GC) 3383-72-0 5g $240 2026-04-30 Buy
Usbiological 269193 1-(2-Chloroethoxy)-4-nitrobenzene Asreported 3383-72-0 1g $396 2026-06-03 Buy
Usbiological 269193 1-(2-Chloroethoxy)-4-nitrobenzene Asreported 3383-72-0 2g $623 2026-06-03 Buy
Usbiological 269193 1-(2-Chloroethoxy)-4-nitrobenzene Asreported 3383-72-0 5g $941 2026-06-03 Buy
Product number Packaging Price Buy
C3523 1g $80 Buy
C3523 5g $240 Buy
269193 1g $396 Buy
269193 2g $623 Buy
269193 5g $941 Buy

1-(2-Chloroethoxy)-4-nitrobenzene Chemical Properties,Uses,Production

Synthesis

4-Nitrophenol

100-02-7

1-Bromo-2-chloroethane

107-04-0

1-(2-Chloroethoxy)-4-nitrobenzene

3383-72-0

1-(2-Chloroethoxy)-4-nitrobenzene was synthesized as follows: cesium carbonate (28.7 mmol) was added to a solution of 4-nitrophenol (28.7 mmol) in anhydrous ethanol (15 mL), followed by 1-bromo-2-chloroethane (86.2 mmol). The reaction mixture was heated to reflux at 80 °C for 8 hours. Upon completion of the reaction, the mixture was cooled, the reaction was quenched with water and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give an orange residue. Grinding of the residue with ethanol (EtOH) gave 1-(2-chloroethoxy)-4-nitrobenzene in 66% yield. Mass spectrum (MS) (m/z): (M+1)+ 202.2.

References

[1] Patent: WO2007/38669, 2007, A2. Location in patent: Page/Page column 170
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 16, p. 4981 - 4991
[3] Patent: WO2005/68452, 2005, A1. Location in patent: Page/Page column 41
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1637 - 1648
[5] Patent: WO2004/5282, 2004, A1. Location in patent: Page 39

100-02-7
107-04-0
3383-72-0
Synthesis of 1-(2-Chloroethoxy)-4-nitrobenzene from 4-Nitrophenol and 1-Bromo-2-chloroethane
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View Lastest Price from 1-(2-Chloroethoxy)-4-nitrobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(2-Chloroethoxy)-4-nitrobenzene pictures 2025-12-24 1-(2-Chloroethoxy)-4-nitrobenzene
3383-72-0
1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
1-(2-Chloroethoxy)-4-nitrobenzene pictures 2019-09-02 1-(2-Chloroethoxy)-4-nitrobenzene
3383-72-0
$7.00 1KG 99% Career Henan Chemical Co
BETA-CHLORO-4-NITROPHENETHOLE 2-CHLOROETHYL-4-NITROPHENYL ETHER 2-(4-NITROPHENOXY)ETHYL CHLORIDE 1-(2-CHLOROETHOXY)-4-NITROBENZENE 4-Nitro-1-(2-chloroethoxy)benzene 4-(2-Chloroethoxy)nitrobenzene β-chloro-4-nitrophenethole 1-(2-CHLOROETHOXY)4-NITROBENZENE, 98+% Benzene, 1-(2-chloroethoxy)-4-nitro- 1-(2-Chloroethoxy)-4-nitrobenzene,97% 3383-72-0 C8H8ClNO3 Building Blocks Nitro Compounds Nitrogen Compounds Organic Building Blocks API intermediates