RIOK2-IN-1
- CAS No.
- 1088216-72-1
- Chemical Name:
- RIOK2-IN-1
- Synonyms
- RIOK2-IN-1;2-Naphthaleneacetamide, N-(4-methyl-2-pyridinyl)-
- CBNumber:
- CB313746594
- Molecular Formula:
- C18H16N2O
- Molecular Weight:
- 276.33
- MDL Number:
- MOL File:
- 1088216-72-1.mol
RIOK2-IN-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| DC Chemicals | DC66354 | RIOK2-IN-1 >98% | 1088216-72-1 | 100mg | $550 | 2026-05-24 | Buy |
| DC Chemicals | DC66354 | RIOK2-IN-1 >98% | 1088216-72-1 | 250mg | $850 | 2026-05-24 | Buy |
| DC Chemicals | DC66354 | RIOK2-IN-1 >98% | 1088216-72-1 | 1g | $1800 | 2026-05-24 | Buy |
RIOK2-IN-1 Chemical Properties, Uses, Production
Uses
RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression[1].
References
[1] Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842. DOI:10.1021/acs.jmedchem.2c00271
RIOK2-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
RIOK2-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 1392 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
