Lu 26-046
- CAS No.
- 143756-51-8
- Chemical Name:
- Lu 26-046
- Synonyms
- Lu 26-046;Isothiazolo[4,5-c]pyridine, 4,5,6,7-tetrahydro-7-methyl-3-(2-propyn-1-yloxy)-, (7R)-
- CBNumber:
- CB31384676
- Molecular Formula:
- C10H12N2OS
- Molecular Weight:
- 208.28
- MDL Number:
- MOL File:
- 143756-51-8.mol
- MSDS File:
- SDS
Lu 26-046 Chemical Properties,Uses,Production
Description
Lu 26-046 is a muscarinic receptor agonist.
Uses
Lu 26-046 is the agonist for muscarinic M1 receptor and M2 receptor and a weak antagonist for M3 receptor, with Ki of 0.51, 26 and 5 nM, respectively. Lu 26-046 exhibits specific stimulus property, that can be recognized by rats[1].
IC 50
mAChR1: 0.51 nM (Ki); mAChR3: 5 nM (Ki); mAChR2: 26 nM (Ki)
References
[1] Arnt J, et al., Discriminative stimulus properties of the muscarinic receptor agonists Lu 26-046 and O-Me-THPO in rats: evidence for involvement of different muscarinic receptor subtypes. Eur J Pharmacol. 1992 Jul 21;218(1):159-69. DOI:10.1016/0014-2999(92)90160-6
Lu 26-046 Preparation Products And Raw materials
Raw materials
Preparation Products
Lu 26-046 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
