ChemicalBook >> CAS DataBase List >>(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol structure

CAS No.: 142217-78-5

Chemical Name:: (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol

Synonyms: Entecavir-5;Entecavir E5;N-oxide impurity1;Entecavir Impurity 1;Entecavir Impurity 53;Entecavir Impurity 13;Entecavir InterMediate V;Entecavir intermediate N5;ENTECAVIR INTERMEDIATE (5TH);Entecavir InterMediate (CAS # 142217-78-5)

CBNumber:: CB31450658

Molecular Formula:: C52H49N5O5

Molecular Weight:: 823.98

MDL Number:: MFCD09750978

MOL File:: 142217-78-5.mol

MSDS File:: SDS

Last updated:2026-05-28 00:58:49

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(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol Properties

Melting point	>87°C (dec.)
Density	1.23
storage temp.	2-8°C
solubility	Acetonitrile (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form	Solid
pka	13.87±0.70(Predicted)
color	White to Off-White
Stability	Hygroscopic
InChIKey	ZLWZEFPIJWNPCO-ABKHIKNWSA-N
SMILES	[C@@H]1(O)[C@@H](N2C3C(N=C2)=C(OCC2=CC=CC=C2)N=C(NC(C2=CC=C(OC)C=C2)(C2=CC=CC=C2)C2=CC=CC=C2)N=3)C[C@H](OCC2=CC=CC=C2)[C@H]1COCC1=CC=CC=C1
CAS DataBase Reference	142217-78-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-E559965-5MG	Entecavir-5	142217-78-5	5mg	$193	2026-06-03	Buy
TRC	TRC-E559965-50MG	Entecavir-5	142217-78-5	50mg	$1528	2026-06-03	Buy
TRC	TRC-E559965-25MG	Entecavir-5	142217-78-5	25mg	$886	2026-06-03	Buy
Matrix Scientific	090535	(1S,2S,3S,5S)-3-(Benzyloxy)-5-(6-(benzyloxy)-2-(((4-methoxyphenyl)diphenylmethylamino)-9H-purin-9-yl)-2-((benzyloxy)methyl)cyclopentanol	142217-78-5	250.00mg	$492	2026-05-18	Buy
Matrix Scientific	090535	(1S,2S,3S,5S)-3-(Benzyloxy)-5-(6-(benzyloxy)-2-(((4-methoxyphenyl)diphenylmethylamino)-9H-purin-9-yl)-2-((benzyloxy)methyl)cyclopentanol	142217-78-5	1.00g	$1092	2026-05-18	Buy

Product number	Packaging	Price	Buy
TRC-E559965-5MG	5mg	$193	Buy
TRC-E559965-50MG	50mg	$1528	Buy
TRC-E559965-25MG	25mg	$886	Buy
090535	250.00mg	$492	Buy
090535	1.00g	$1092	Buy

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol Chemical Properties, Uses, Production

Uses

Entecavir-5 is used in the preparation of the anti-HBV drug Entecavir.

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol Preparation Products And Raw materials

Raw materials

Preparation Products

2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol Suppliers

Global Suppliers ( 181)

Supplier	Tel	Email	Country	ProdList	Advantage
Cangzhou Dafeng Chemical Co., Ltd	18112498720	dfhxchemical@163.com	China	27	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6740	52
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd	13801189771 13801208576	maggie@chinazhongshuo.com	China	88	65
Wuhan Fortuna Chemical Co., Ltd	027-59207852 13308628970	buy@fortunachem.com	China	2684	58
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
Shanghai Witofly Chemical Co.,Ltd		sales@witofly.com	China	2853	52
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9656	58

Supplier	Advantage
Cangzhou Dafeng Chemical Co., Ltd	58
Chembest Research Laboratories Limited	61
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Adamas Reagent, Ltd.	59
XiaoGan ShenYuan ChemPharm co,ltd	52
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd	65
Wuhan Fortuna Chemical Co., Ltd	58
Shanghai T&W Pharmaceutical Co., Ltd.	58
Shanghai Witofly Chemical Co.,Ltd	52
Clearsynth Labs Limited	58

View Latest Price from (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol 142217-78-5	$150.00-880.00	5g	99%	50	Zibo Hangyu Biotechnology Development Co., Ltd
2025-12-24	(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol 142217-78-5		1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2024-03-28	(1S,2S,3S,5S)-5-(2-((4-methoxyphenyl)diphenylmethylamino)-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-((benzyloxy)methyl)cyclopentanol 142217-78-5		25kg	HPLC>98%;ee%>98.5		PNP Biotech Co. Ltd

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol
142217-78-5
$150.00-880.00
99%
Zibo Hangyu Biotechnology Development Co., Ltd

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol
142217-78-5
$0.10
99.0%
Shaanxi Dideu Medichem Co. Ltd

(1S,2S,3S,5S)-5-(2-((4-methoxyphenyl)diphenylmethylamino)-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-((benzyloxy)methyl)cyclopentanol
142217-78-5
$0.00
HPLC>98%;ee%>98.5
PNP Biotech Co. Ltd

142217-78-5 ((2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol) Related Search:

2-AMino-1,9-dihydro-9-[(1S,3R,4S)-4-(hydroxydiMethylsilyl)-3-(hydroxyMethyl)-2-Methylenecyclopentyl]-6H-purin-6-one (1s-trans)-2-[(phenylmethoxy)methyl]-3-cyclopenten-1-ol (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine Anisole

Guaiacol 4-Methoxybenzyl cyanide (Trifluoromethoxy)benzene 6-Aminocaproic acid 4-Methoxyphenol

p-Anisidine p-Anisaldehyde 4-Methoxybenzyl alcohol Tris(hydroxymethyl)aminomethane 4-Methoxybenzoic acid

Glycine Aminoethoxyvinyl glycine hydrochloride Entecavir

1of4

(2R,3S,5S)-3-(Benzyloxy)-5-(6-benzyloxy)-2-(4-methyoxyphenyl)diphenylmethylamino)-9H-purin-9-yl)-2-benzyloxymethyl)cyclopentanol (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9- (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol ,99% [1S-(1α,2β,3α,5β)]-5-[2-[[(4-Methoxyphenyl)-diphenylMethyl]aMino]-6-(phenylMethoxy)-9H- purin-9-yl]-3-(phenylMethoxy)-2-[(phenyl-Methoxy)Methyl]cyclopentanol Entecavir InterMediate V (1S,2S,3S,5S)-5-(2-((4-Methoxyphenyl)diphenylMethylaMino)-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-((benzyloxy)Methyl)cyclopentanol (1S,2S,3S,5S)-3-(benzyloxy)-5-(6-(benzyloxy)-2-(((4-Methoxyphenyl)diphenylMethyl)aMino)-9H-purin-9-yl)-2-((benzyloxy)Methyl)cyclopentanol Entecavir Impurity 53 (1S,2S,3S,5S)-3-(benzyloxy)-5-[6-(benzyloxy)-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-9H-purin-9-yl]-2-[(benzyloxy)methyl]cyclopentan-1-ol 5-[2-[[(4-methoxyphenyl)-diphenylmethyl]amino]-6-phenylmethoxy-9-purinyl]-3-phenylmethoxy-2-(phenylmethoxymethyl)-1-cyclopentanol The China supplier of Entecavir Intermediate Cas:142217-78-5 (1S,3R,4S)-3-(benzyloxy-5-[6-(benzyloxy)-2 -((4-Methoxyphenyl)diphenylMethylaMino) -9H- purin-9-yl]-2-(benzyloxyMethyl)cyclopentanol Entecavir InterMediate (CAS # 142217-78-5) (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-Methoxyphenyl)diphenylMethyl]aMino]-6-(phenylMethoxy)-9H-purin-9-yl]-2-(benzyloxyMethyl)cyclopentanol (interMediate step 4) (1S,2S,3S,5S)-3-BENZYLOXY)-5(6-BENZYLOXY)-2-((4-METHOXYPHENYL)DIPHENYLMETHYLAMINO)-9H-PURIN-9-YL)-2-(BENZYLOXYMETH (2R,3S,5S)-3-(Benzyloxy)-5-[6-(benzyloxy)-2-{[(4-Methoxyphenyl)(diphenyl)Methyl]aMino}-9H-purin-9-yl]-2-[(benzyloxy)Methyl]cyclopentanol (2R,3S,5S)-3-(benzyloxy)-5-[6-(benzyloxy)-2-{[(4-Methoxyphenyl)diphenylMethyl]aMino}-9H-purin-9-yl]-2-[(benzyloxy)Methyl]cyclopentan-1-ol (1S,2S,3S,5S)-3-(Benzyloxy)-5-(6-(benzyloxy)-2-(((4-methoxyphenyl)diphenylmethyl amino)-9H-purin- (1S,2S,3S,5S)-5-[2-[[(4-Methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]cyclopentanol Entecavir E5 (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol###142217-78-5 (1S,2S,3S,5S)-3-(Benzyloxy)-5-(6-(benzyloxy)-2-(((4-methoxyphenyl)diphenylmethylamino)-9H-puri (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-pu Entecavir intermediate N5 Entecavir Impurity 13 ENTECAVIR INTERMEDIATE (5TH) 2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-a(benzyloxymethyl)cyclopentanol Entecavir Impurity 1 N-oxide impurity1 Cyclopentanol, 5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, (1S,2S,3S,5S)- 5-[2-[[(4-Methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]cyclopentanol (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmet... "(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)" (1S,2S,3S,5S)-5-[2-[[(4-Methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-3-(phen (2R,3S,5S)-3- (Benzyloxy)-5-[2-[[(4-methoxyphenyl)- diphenylmethyl]amino]-6- (phenylmethoxy)-9H-purin-9-yl]- 2- (benzyloxymethyl) cyclopentanol (Ent-V) (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylm (1S,2S,3S,5S)-3-(Benzyloxy)-5-(6-(benzyloxy)-2-(((4-methoxyphenyl)diphenylmethyl)amino)-9H-purin-9-yl)-2-((benzyloxy)methyl)cyclopentan-1-ol - [B88612] Entecavir-5 (2R,3S,5S)-3-Benzyloxy-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol 142217-78-5 42217-78-5 C52H49N5O5