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2-Chloro-3-methoxyaniline

2-Chloro-3-methoxyaniline Structure
2-Chloro-3-methoxyaniline structure
CAS No.
113206-03-4
Chemical Name:
2-Chloro-3-methoxyaniline
Synonyms
2-chloro-3-Methoxy-;2-Chloro-3-methoxyaniline;2-chloro-3-methoxyl-aniline;2-Chloro-3-methoxybenzenamine;(2-Chloro-3-methoxyphenyl)amine;Benzenamine, 2-chloro-3-methoxy-;3-AMino-2-chloroanisole[2-Chloro-3-Methoxyaniline];1,3-ADAMANTANEDIMETHANOL,ALPHA,ALPHA,ALPHA'',ALPHA';1,3-ADAMANTANEDIMETHANOL,ALPHA,ALPHA,ALPHA'',ALPHA''-TETRAMETHYL-(6CI)
CBNumber:
CB31465656
Molecular Formula:
C7H8ClNO
Molecular Weight:
157.6
MDL Number:
MFCD08691737
MOL File:
113206-03-4.mol
MSDS File:
SDS
Last updated:2026-05-28 00:57:52
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2-Chloro-3-methoxyaniline Properties

Melting point 50 °C
Boiling point 125 °C(Press: 3 Torr)
Density 1.234±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 2.23±0.10(Predicted)
Appearance Gray to brown Solid
InChI InChI=1S/C7H8ClNO/c1-10-6-4-2-3-5(9)7(6)8/h2-4H,9H2,1H3
InChIKey ZWPVZYDSURGWSY-UHFFFAOYSA-N
SMILES C1(N)=CC=CC(OC)=C1Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

2-Chloro-3-methoxyaniline price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FC07940 2-Chloro-3-methoxyaniline 113206-03-4 2g $150 2026-06-04 Buy
Biosynth FC07940 2-Chloro-3-methoxyaniline 113206-03-4 5g $252.2 2026-06-04 Buy
Biosynth FC07940 2-Chloro-3-methoxyaniline 113206-03-4 10g $403.5 2026-06-04 Buy
Biosynth FC07940 2-Chloro-3-methoxyaniline 113206-03-4 25g $807.25 2026-06-04 Buy
Biosynth FC07940 2-Chloro-3-methoxyaniline 113206-03-4 50g $2498 2026-06-04 Buy
Product number Packaging Price Buy
FC07940 2g $150 Buy
FC07940 5g $252.2 Buy
FC07940 10g $403.5 Buy
FC07940 25g $807.25 Buy
FC07940 50g $2498 Buy

2-Chloro-3-methoxyaniline Chemical Properties, Uses, Production

Uses

2-Chloro-3-methoxyaniline is a reactant used in the preparation of dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.

Synthesis

Benzene, 2-chloro-1-methoxy-3-nitro-

3970-39-6

2-Chloro-3-methoxyaniline

113206-03-4

General procedure for the synthesis of 2-chloro-3-methoxyaniline from 2-chloro-3-nitroanisole: 2-chloro-3-nitroanisole (1.38 g, 7.36 mmol) was dissolved in a solvent mixture of glacial acetic acid (19 mL) and acetonitrile (19 mL). To this solution was added iron powder (1.64 g, 29.4 mmol). The reaction mixture was stirred under reflux conditions for 3.5 hours. After completion of the reaction, the mixture was diluted with water (70 mL) and neutralized with solid sodium carbonate (Na2CO3). Subsequently, the product was extracted with dichloromethane (3 x 150 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the crude product 2-chloro-3-methoxyaniline (1.2 g, 100% yield) as a yellow oil. The product was used directly in the next reaction without further purification. Mass spectrometry (MS) analysis showed a molecular ion peak of 157.9 (MH)+; high performance liquid chromatography (HPLC, with TFA as additive) showed a purity of 86% at 220 nm.

References

[1] Patent: WO2004/103996, 2004, A1. Location in patent: Page 42-43
[2] Patent: WO2006/7700, 2006, A1. Location in patent: Page/Page column 62
[3] Patent: US2006/19905, 2006, A1. Location in patent: Page/Page column 25
[4] Patent: WO2006/85, 2006, A1. Location in patent: Page/Page column 77-78
[5] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000

2-Chloro-3-methoxyaniline synthesis

3970-39-6
113206-03-4
Synthesis of 2-Chloro-3-methoxyaniline from Benzene, 2-chloro-1-methoxy-3-nitro-

2-Chloro-3-methoxyaniline Preparation Products And Raw materials

Raw materials

Carbamic acid, N-(2-chloro-3-methoxyphenyl)-, 1,1-dimethylethyl ester Benzene, 2-chloro-1-methoxy-3-nitro- 2-Methoxy-6-nitro-phenylamine Ethanol Acetic acid
Iron

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Preparation Products

2-Chloro-3-methoxyaniline Suppliers

Global Suppliers ( 140)
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6744 52
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Supplier Advantage
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
XiaoGan ShenYuan ChemPharm co,ltd 52
Shandong Xiya Chemical Co., Ltd 57
Shanghai Ennopharm Co., Ltd. 65

View Latest Price from 2-Chloro-3-methoxyaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-3-methoxyaniline pictures 2020-01-05 2-Chloro-3-methoxyaniline
113206-03-4
 $9.80 1KG 97%-99% 1kg -1000kg Career Henan Chemical Co

2-Chloro-3-methoxyaniline Spectrum

2-Chloro-3-methoxyaniline(113206-03-4)1HNMR

113206-03-4 (2-Chloro-3-methoxyaniline) Related Search:

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2-Chloro-3-methoxybenzenamine (2-Chloro-3-methoxyphenyl)amine 2-Chloro-3-methoxyaniline 1,3-ADAMANTANEDIMETHANOL,ALPHA,ALPHA,ALPHA'',ALPHA' Benzenamine, 2-chloro-3-methoxy- 2-chloro-3-methoxyl-aniline 1,3-ADAMANTANEDIMETHANOL,ALPHA,ALPHA,ALPHA'',ALPHA''-TETRAMETHYL-(6CI) 2-chloro-3-Methoxy- 3-AMino-2-chloroanisole[2-Chloro-3-Methoxyaniline] 113206-03-4 Naphthyridine,Quinoline Drug Intermediates API intermediates Anilines, Amides & Amines Anisoles, Alkyloxy Compounds & Phenylacetates Chlorine Compounds