2-Methoxy-6-nitro-phenylamine
- CAS No.
- 16554-45-3
- Chemical Name:
- 2-Methoxy-6-nitro-phenylamine
- Synonyms
- 2-METHOXY-6-NITROANILINE;2-amino-3-nitroanisole;Einecs 240-617-4;6-nitro-o-anisidine;Methoxy-6-nitroaniline;2-Nitro-6-(methoxy)aniline;2-methoxy-6-nitrobenzenamine;2-Methoxy-6-nitro-phenylamine;2-Methoxy-6-Nitrophenylamine95%;BenzenaMine, 2-Methoxy-6-nitro-
- CBNumber:
- CB8116833
- Molecular Formula:
- C7H8N2O3
- Molecular Weight:
- 168.15
- MDL Number:
- MFCD01930197
- MOL File:
- 16554-45-3.mol
- MSDS File:
- SDS
| Melting point | 73-78℃ |
|---|---|
| Boiling point | 322.1±22.0 °C(Predicted) |
| Density | 1.318±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | -0.35±0.25(Predicted) |
| color | Light yellow to brown |
| InChI | 1S/C7H8N2O3/c1-12-6-4-2-3-5(7(6)8)9(10)11/h2-4H,8H2,1H3 |
| InChIKey | NDKWDGCTUOOAPF-UHFFFAOYSA-N |
| SMILES | NC1=C([N+]([O-])=O)C=CC=C1OC |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H331-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2921420090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Methoxy-6-nitro-phenylamine price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS020857 | 2-Methoxy-6-nitroaniline | 16554-45-3 | 100 mg | $39.1 | 2026-04-30 | Buy |
| Activate Scientific | AS21648 | 2-Methoxy-6-nitroaniline 97% | 16554-45-3 | 1g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS21648 | 2-Methoxy-6-nitroaniline 97% | 16554-45-3 | 5g | $42 | 2026-06-04 | Buy |
| Apolloscientific | OR300658 | 2-Methoxy-6-nitroaniline ≥95% | 16554-45-3 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS21648 | 2-Methoxy-6-nitroaniline 97% | 16554-45-3 | 25g | $201 | 2026-06-04 | Buy |
2-Methoxy-6-nitro-phenylamine Chemical Properties, Uses, Production
Uses
2-Methoxy-6-nitroaniline is useful for preparing pyrimidine derivatives as FGFR4 inhibitors.
Synthesis
603-85-0
74-88-4
16554-45-3
Step 1: Synthesis of 2-methoxy-6-nitroaniline; A mixture of 2-amino-3-nitrophenol (11.66 g, 76 mmol) and potassium carbonate (K2CO3, 12.55 g, 91 mmol) was stirred in N,N-dimethylformamide (DMF, 100 mL) for 1 hour. Subsequently, a solution of iodomethane (5.68 mL, 91 mmol) in DMF (10 mL) was added dropwise and the reaction mixture was continued to be stirred for 14 hours. After completion of the reaction, the reaction mixture was diluted with distilled water (H2O) and extracted with ethyl acetate (EtOAc, 2 × 100 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give a dark solid. The crude product was purified by recrystallization from hexane to give 2-amino-3-nitroanisole as an orange solid (11.6 g, 91% yield). Liquid chromatography-mass spectrometry (LCMS, ES+) showed m/z 169.0 ([M + H]+).
References
[1] Patent: WO2012/40040, 2012, A1. Location in patent: Page/Page column 47-48
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 17, p. 5352 - 5362
[3] Patent: US2012/88767, 2012, A1. Location in patent: Page/Page column 16; 22
[4] Journal of Asian Natural Products Research, 2011, vol. 13, # 4, p. 330 - 340
[5] European Journal of Medicinal Chemistry, 2013, vol. 68, p. 222 - 232
2-Methoxy-6-nitro-phenylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from 2-Methoxy-6-nitro-phenylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-METHOXY-6-NITRO-PHENYLAMINE
16554-45-3
|
$1.00-80.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2020-02-26 | 2-Methoxy-6-nitroaniline
16554-45-3
|
1KG | 99.0% | 100 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | 2-METHOXY-6-NITRO-PHENYLAMINE
16554-45-3
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-METHOXY-6-NITRO-PHENYLAMINE
16554-45-3
- $1.00-80.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Methoxy-6-nitroaniline
16554-45-3
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-METHOXY-6-NITRO-PHENYLAMINE
16554-45-3
- $1.00
- 99%
- Career Henan Chemical Co
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