1'-Hydroxymidazolam
- CAS No.
- 59468-90-5
- Chemical Name:
- 1'-Hydroxymidazolam
- Synonyms
- α-Hydroxymidazolam;ALPHA-HYDROXYMIDAZOLAM;RO 21-6347;1-Oh-mdz;A-HYDROXYMIDAZOLAM;1Hydroxymidazolame;1-HYDROXY MIDAZOLAM;1'-Hydroxymidazolam;Midazolam Impurity 1;Midazolam Impurity 12
- CBNumber:
- CB3147586
- Molecular Formula:
- C18H13ClFN3O
- Molecular Weight:
- 341.77
- MDL Number:
- MFCD00871458
- MOL File:
- 59468-90-5.mol
- MSDS File:
- SDS
| Melting point | 264-266oC |
|---|---|
| Boiling point | 540.6±60.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMF: 2 mg/ml; DMSO: 1 mg/ml |
| form | A crystalline solid |
| pka | 13.59±0.10(Predicted) |
| color | white or off-white |
| Major Application | clinical testing |
| InChI | 1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2 |
| InChIKey | QHSMEGADRFZVNE-UHFFFAOYSA-N |
| SMILES | OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12 |
| FDA UNII | E5142BN92Z |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| target organs | Eyes | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
|||||||||
| NFPA 704 |
|
1'-Hydroxymidazolam price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H-922 | α-Hydroxymidazolam solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 59468-90-5 | 1mL | $358 | 2026-04-30 | Buy |
| Sigma-Aldrich | H-902 | α-Hydroxymidazolam solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 59468-90-5 | 1mL | $39 | 2026-04-30 | Buy |
| Cayman Chemical | 39954 | α-hydroxy Midazolam (CRM) | 59468-90-5 | 100μg | $39 | 2026-04-30 | Buy |
| Cayman Chemical | 39954 | α-hydroxy Midazolam (CRM) | 59468-90-5 | 1mg | $290 | 2026-04-30 | Buy |
| Cayman Chemical | 10385 | α-hydroxy Midazolam ≥95% | 59468-90-5 | 1mg | $160 | 2026-04-30 | Buy |
1'-Hydroxymidazolam Chemical Properties,Uses,Production
Description
1''-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.
Chemical Properties
White Solid
Uses
CYP3A4 metabolite of midazolam
Uses
A metabolite of Midazolam (M343000).
Definition
ChEBI: 1-hydroxymidazolam is an imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. It has a role as a drug metabolite, a human blood serum metabolite and a human urinary metabolite. It is an imidazobenzodiazepine, an organochlorine compound, a member of monofluorobenzenes and an aromatic primary alcohol. It is functionally related to a midazolam.
References
[1] M D PERLOFF. Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 292 2: 618-628.
[2] T M BAUER. Prolonged sedation due to accumulation of conjugated metabolites of midazolam.[J]. Lancet (London, England), 1995, 346 8968: 145-147. DOI: 10.1016/s0140-6736(95)91209-6
[3] RYOSUKE NEGORO. Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System[J]. Cells, 2022. DOI: 10.3390/cells11101677
1'-Hydroxymidazolam Preparation Products And Raw materials
Raw materials
Preparation Products
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