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4-Cyano-2-fluorobenzoic acid methyl ester

4-Cyano-2-fluorobenzoic acid methyl ester Structure
4-Cyano-2-fluorobenzoic acid methyl ester structure
CAS No.
175596-01-7
Chemical Name:
4-Cyano-2-fluorobenzoic acid methyl ester
Synonyms
4-Cyano-2-fluorobenzoic acid methyl ester
CBNumber:
CB31484877
Molecular Formula:
C9H6FNO2
Molecular Weight:
179.15
MDL Number:
MFCD04335187
MOL File:
175596-01-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:39
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4-Cyano-2-fluorobenzoic acid methyl ester Properties

Boiling point 296.0±30.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P271-P261-P280
HS Code  2916399090

4-Cyano-2-fluorobenzoic acid methyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FC67185 4-Cyano-2-fluorobenzoic acid methyl ester 175596-01-7 25g $150 2026-06-04 Buy
Biosynth FC67185 4-Cyano-2-fluorobenzoic acid methyl ester 175596-01-7 10g $150 2026-06-04 Buy
Apolloscientific PC500686 Methyl 4-cyano-2-fluorobenzoate tech 175596-01-7 5g $55 2026-06-04 Buy
Apolloscientific PC500686 Methyl 4-cyano-2-fluorobenzoate tech 175596-01-7 25g $196 2026-06-04 Buy
Apolloscientific PC500686 Methyl 4-cyano-2-fluorobenzoate tech 175596-01-7 50g $343 2026-06-04 Buy
Product number Packaging Price Buy
FC67185 25g $150 Buy
FC67185 10g $150 Buy
PC500686 5g $55 Buy
PC500686 25g $196 Buy
PC500686 50g $343 Buy

4-Cyano-2-fluorobenzoic acid methyl ester Chemical Properties, Uses, Production

Synthesis

4-CYANO-2-FLUOROBENZOIC ACID

164149-28-4

Iodomethane

74-88-4

4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER

175596-01-7

Step (i) Potassium carbonate (3.70 g, 26.7 mmol) was added to a solution of 4-cyano-2-fluorobenzoic acid (4 g, 24.3 mmol) in N,N-dimethylformamide (DMF, 350 mL). After stirring for 15 min at room temperature, iodomethane (1.66 mL, 26.7 mmol) was slowly added. The reaction vial was sealed and the reaction mixture was stirred at 40 °C for 2 hours. Upon completion of the reaction, most of the DMF was removed by distillation under reduced pressure. the residue was subjected to liquid-liquid partitioning with dichloromethane (DCM, 50 mL) and saturated saline (50 mL). The organic phase was separated and filtered through a short column of silica gel to remove possible solid impurities. Finally, the organic phase was concentrated under reduced pressure to afford methyl 4-cyano-2-fluorobenzoate (4.1 g, 94% yield). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) δ ppm: 3.96 (s, 3H), 7.44-7.48 (m, 1H), 7.49-7.53 (m, 1H), 8.01-8.05 (m, 1H).

References

[1] Patent: WO2015/25164, 2015, A1. Location in patent: Page/Page column 81-82
[2] Patent: US2015/57298, 2015, A1. Location in patent: Paragraph 0551
[3] Patent: US2016/207883, 2016, A1. Location in patent: Paragraph 0916-0918
[4] Patent: WO2009/124962, 2009, A2. Location in patent: Page/Page column 141

4-Cyano-2-fluorobenzoic acid methyl ester Preparation Products And Raw materials

Raw materials

Dimethyl sulfate Methyl 4-bromo-2-fluorobenzoate Methanol ZINC CYANIDE 4-Cyano-2-fluorobenzoic acid
Iodomethane N,N-Dimethylformamide Potassium carbonate

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Preparation Products

4-Cyano-2-fluorobenzoic acid methyl ester Suppliers

Global Suppliers ( 72)
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Tianjin Anhao Biological Technology Co., Ltd. sales@ahpharmatech.com China 5734 55
Changzhou Tianrui Pharmaceutical Technology Co., Ltd. 0519-85386832 13382812559 sales@cztrchem.com China 1211 56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Changzhou Anxuan Chemical, Co., Ltd. 13912302692 sales@anxuanchem.com China 4824 58
Taizhou GreenChem Pharmaceutical Co., Ltd. 0514-86654616 15366892466; greenchem@tzglmk.com China 498 56
ShangHai Siyan Biological Technology Co., Ltd. 021-50908862，442785678，326799392 18721037013 siyansales@126.com China 9612 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
Bide Pharmatech Ltd. 60
Tianjin Anhao Biological Technology Co., Ltd. 55
Changzhou Tianrui Pharmaceutical Technology Co., Ltd. 56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
Cool Pharm, Ltd 58
Changzhou Anxuan Chemical, Co., Ltd. 58
Taizhou GreenChem Pharmaceutical Co., Ltd. 56
ShangHai Siyan Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from 4-Cyano-2-fluorobenzoic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Cyano-2-Fluoro-Benzoic Acid Methyl Ester pictures 2026-02-02 4-Cyano-2-Fluoro-Benzoic Acid Methyl Ester
175596-01-7
 50mg 99%HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd

4-Cyano-2-fluorobenzoic acid methyl ester Spectrum

4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER(175596-01-7)1HNMR4-CYANO-2-FLUOROBENZOIC ACID METHYL ESTER(175596-01-7)19FNMR

175596-01-7 (4-Cyano-2-fluorobenzoic acid methyl ester) Related Search:

Methyl dihydrojasmonate Methyl salicylate Sodium cyanoborohydride 4-Cyano-2-fluorobenzoic acid p-Tolyl isocyanate
Tolylene-2,4-diisocyanate

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4-Cyano-2-fluorobenzoic acid methyl ester 175596-01-7 Aromatic Esters