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Methyl 4-bromo-2-fluorobenzoate

Methyl 4-bromo-2-fluorobenzoate structure

CAS No.: 179232-29-2

Chemical Name:: Methyl 4-bromo-2-fluorobenzoate

Synonyms: Fluoro-4-bromobenzoate;Enzalutamide Impurity 15;Enzalutamide ImpuritiesC;Enzalutamide EP Impurity C;Methy 4-bromo-2-fluorobenzoate;Methyl 4-bromo-2-fluorobenzoate;Methyl 2-fluoro-4-bromobenzoate;Methyl 4-bromo-2-fluorobenzoate, 98%;4-BROMO-2-FLUOROBENZOIC ACID METHYL ESTER;2-Fluoro-4-bromobenzoic acid methyl ester

CBNumber:: CB61457618

Molecular Formula:: C8H6BrFO2

Molecular Weight:: 233.03

MDL Number:: MFCD06203731

MOL File:: 179232-29-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:15

Product description	Number	Pack Size	Price
Methyl 4-Bromo-2-fluorobenzoate	M3229	5G	$58
Methyl 4-Bromo-2-fluorobenzoate	M3229	25G	$230
METHYL 4-BROMO-2-FLUOROBENZOATE 97%	63530	25G	$29
METHYL 4-BROMO-2-FLUOROBENZOATE 97%	63530	100G	$79
Methyl 4-bromo-2-fluorobenzoate ≥98%(GC)	45269	5G	$45.7
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Methyl 4-bromo-2-fluorobenzoate Properties

Melting point	58-60℃
Boiling point	272.7±25.0℃ (760 Torr)
Density	1.577±0.06 g/cm3 (20 ºC 760 Torr)
Flash point	118.7±23.2℃
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
InChI	InChI=1S/C8H6BrFO2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3
InChIKey	DLILIUSWDLJMCE-UHFFFAOYSA-N
SMILES	C(OC)(=O)C1=CC=C(Br)C=C1F

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

HS Code

2916399090

NFPA 704

	0
2		0

Methyl 4-bromo-2-fluorobenzoate price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M3229	Methyl 4-Bromo-2-fluorobenzoate	179232-29-2	5G	$58	2026-04-30	Buy
TCI Chemical	M3229	Methyl 4-Bromo-2-fluorobenzoate	179232-29-2	25G	$230	2026-04-30	Buy
AstaTech	63530	METHYL 4-BROMO-2-FLUOROBENZOATE 97%	179232-29-2	25G	$29	2026-04-30	Buy
AstaTech	63530	METHYL 4-BROMO-2-FLUOROBENZOATE 97%	179232-29-2	100G	$79	2026-04-30	Buy
Chem-Impex	45269	Methyl 4-bromo-2-fluorobenzoate ≥98%(GC)	179232-29-2	5G	$45.7	2026-05-19	Buy

Product number	Packaging	Price	Buy
M3229	5G	$58	Buy
M3229	25G	$230	Buy
63530	25G	$29	Buy
63530	100G	$79	Buy
45269	5G	$45.7	Buy

Methyl 4-bromo-2-fluorobenzoate Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Uses

4-Bromo-2-fluorobenzoic Acid Methyl Ester is the methyl ester derivative of 4-Bromo-2-fluorobenzoic Acid (B684620) and is used as a reagent in the synthesis of aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-Chagas agents.

Synthesis

67-56-1

112704-79-7

179232-29-2

Step 1: To a stirred solution of 4-bromo-2-fluorobenzoic acid (15.0 g, 68.49 mmol, 1 eq.) in methanol (150 mL) was slowly added thionyl chloride (23.09 mL, 136.9 mmol, 2 eq.) at 0 °C. The reaction mixture was kept at 0 °C for 15 minutes before being brought to room temperature and stirring was continued for 12 hours. After completion of the reaction, methanol was removed by evaporation under reduced pressure and the residue was diluted with ethyl acetate (250 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate solution, brine (150 mL) and deionized water (150 mL). The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 4-bromo-2-fluorobenzoate (15 g, 93% yield) as an off-white solid (LC-MS purity 99%; TLC conditions: ethyl acetate/petroleum ether (3:7), Rf value 0.8).

References

[1] Patent: WO2004/46096, 2004, A2. Location in patent: Page 38
[2] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 19, p. 7651 - 7668
[4] Patent: WO2015/48306, 2015, A1. Location in patent: Page/Page column 88; 112
[5] Patent: WO2013/68461, 2013, A1. Location in patent: Page/Page column 105; 106; 109

Methyl 4-bromo-2-fluorobenzoate synthesis

Synthesis of Methyl 4-bromo-2-fluorobenzoate from 4-Bromo-2-fluorobenzoic acid and (TRIMETHYLSILYL)DIAZOMETHANE

Methyl 4-bromo-2-fluorobenzoate Preparation Products And Raw materials

Raw materials

4-Bromo-2-fluorobenzoic acid 4-BROMO-2-FLUOROBENZOYL CHLORIDE Methanol Iodomethane (TRIMETHYLSILYL)DIAZOMETHANE

Preparation Products

4-Cyano-2-fluorobenzyl alcohol METHYL 2-FLUORO-4-HYDROXYBENZOATE 4-BROMO-2-FLUOROBENZYL ALCOHOL 6-Bromo-3-hydroxy-benzo[b]thiophene-2-carboxylic acid methyl ester 3-Fluoro-4'-(trifluoroMethyl)-[1,1'-biphenyl]-4-carboxylic acid

2-(4-bromo-2-fluorophenyl)propan-2-ol

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Methyl 4-bromo-2-fluorobenzoate Suppliers

Global( 263)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Accela ChemBio Inc.	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from Methyl 4-bromo-2-fluorobenzoate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-21	Ethyl 2-fluoro-3-oxopentanoate 179232-29-2	US $0.00 / kg	1kg	99%min	20000kgs	HANGZHOU HAILAN CHEMICAL CO.,LTD.
2025-12-01	Methyl 4-bromo-2-fluorobenzoate 179232-29-2	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2019-07-06	Methyl 4-bromo-2-fluorobenzoate 179232-29-2	US $2.00 / KG	1KG	99%	1000kg	Career Henan Chemical Co

Ethyl 2-fluoro-3-oxopentanoate
179232-29-2
US $0.00 / kg
99%min
HANGZHOU HAILAN CHEMICAL CO.,LTD.

Methyl 4-bromo-2-fluorobenzoate
179232-29-2
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

Methyl 4-bromo-2-fluorobenzoate
179232-29-2
US $2.00 / KG
99%
Career Henan Chemical Co

Methyl 4-bromo-2-fluorobenzoate Spectrum

Methyl 4-bromo-2-fluorobenzoate(179232-29-2)¹HNMR

179232-29-2(Methyl 4-bromo-2-fluorobenzoate)Related Search:

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EnzalutaMide IMpurity Enzalutamide Enzalutamide

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Methyl 4-bromo-2-fluorobenzoate Fluoro-4-bromobenzoate 4-BROMO-2-FLUOROBENZOIC ACID METHYL ESTER Methyl 2-fluoro-4-bromobenzoate Enzalutamide Impurity 15 Enzalutamide EP Impurity C 2-Fluoro-4-bromobenzoic acid methyl ester Benzoic acid, 4-bromo-2-fluoro-, methyl ester Methyl 4-bromo-2-fluorobenzoate(For export only) Methy 4-bromo-2-fluorobenzoate Enzalutamide ImpuritiesC Methyl 4-bromo-2-fluorobenzoate, 98% 179232-29-2 Aromatic Esters blocks Bromides Carboxes FluoroCompounds