ChemicalBook >> CAS DataBase List >>Methyl 4-bromo-2-fluorobenzoate

Methyl 4-bromo-2-fluorobenzoate

Methyl 4-bromo-2-fluorobenzoate structure

CAS No.: 179232-29-2

Chemical Name:: Methyl 4-bromo-2-fluorobenzoate

Synonyms: 4-BROMO-2-FLUOROBENZOIC ACID METHYL ESTER;Methyl 2-fluoro-4-bromobenzoate;2-Fluoro-4-bromobenzoic acid methyl ester;Fluoro-4-bromobenzoate;Enzalutamide ImpuritiesC;Enzalutamide Impurity 15;Enzalutamide EP Impurity C;Methy 4-bromo-2-fluorobenzoate;Methyl 4-bromo-2-fluorobenzoate;Methyl 4-bromo-2-fluorobenzoate, 98%

CBNumber:: CB61457618

Molecular Formula:: C8H6BrFO2

Molecular Weight:: 233.03

MDL Number:: MFCD06203731

MOL File:: 179232-29-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-05 19:35:02

Request For Quotation

Methyl 4-bromo-2-fluorobenzoate Properties

Melting point	58-60℃
Boiling point	272.7±25.0℃ (760 Torr)
Density	1.577±0.06 g/cm3 (20 ºC 760 Torr)
Flash point	118.7±23.2℃
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
InChI	InChI=1S/C8H6BrFO2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3
InChIKey	DLILIUSWDLJMCE-UHFFFAOYSA-N
SMILES	C(OC)(=O)C1=CC=C(Br)C=C1F

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

HS Code

2916399090

NFPA 704

	0
2		0

Methyl 4-bromo-2-fluorobenzoate price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M3229	Methyl 4-Bromo-2-fluorobenzoate	179232-29-2	5G	$58	2026-04-30	Buy
TCI Chemical	M3229	Methyl 4-Bromo-2-fluorobenzoate	179232-29-2	25G	$230	2026-04-30	Buy
TRC	TRC-B683335-25G	4-Bromo-2-fluorobenzoic Acid Methyl Ester	179232-29-2	25g	$223	2026-06-03	Buy
AstaTech	63530	METHYL 4-BROMO-2-FLUOROBENZOATE 97%	179232-29-2	25G	$29	2026-04-30	Buy
AstaTech	63530	METHYL 4-BROMO-2-FLUOROBENZOATE 97%	179232-29-2	100G	$79	2026-04-30	Buy

Product number	Packaging	Price	Buy
M3229	5G	$58	Buy
M3229	25G	$230	Buy
TRC-B683335-25G	25g	$223	Buy
63530	25G	$29	Buy
63530	100G	$79	Buy

Methyl 4-bromo-2-fluorobenzoate Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Uses

4-Bromo-2-fluorobenzoic Acid Methyl Ester is the methyl ester derivative of 4-Bromo-2-fluorobenzoic Acid (B684620) and is used as a reagent in the synthesis of aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-Chagas agents.

Synthesis

67-56-1

112704-79-7

179232-29-2

Step 1: To a stirred solution of 4-bromo-2-fluorobenzoic acid (15.0 g, 68.49 mmol, 1 eq.) in methanol (150 mL) was slowly added thionyl chloride (23.09 mL, 136.9 mmol, 2 eq.) at 0 °C. The reaction mixture was kept at 0 °C for 15 minutes before being brought to room temperature and stirring was continued for 12 hours. After completion of the reaction, methanol was removed by evaporation under reduced pressure and the residue was diluted with ethyl acetate (250 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate solution, brine (150 mL) and deionized water (150 mL). The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 4-bromo-2-fluorobenzoate (15 g, 93% yield) as an off-white solid (LC-MS purity 99%; TLC conditions: ethyl acetate/petroleum ether (3:7), Rf value 0.8).

References

[1] Patent: WO2004/46096, 2004, A2. Location in patent: Page 38
[2] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 19, p. 7651 - 7668
[4] Patent: WO2015/48306, 2015, A1. Location in patent: Page/Page column 88; 112
[5] Patent: WO2013/68461, 2013, A1. Location in patent: Page/Page column 105; 106; 109

Methyl 4-bromo-2-fluorobenzoate synthesis

Synthesis of Methyl 4-bromo-2-fluorobenzoate from 4-Bromo-2-fluorobenzoic acid and (TRIMETHYLSILYL)DIAZOMETHANE

Methyl 4-bromo-2-fluorobenzoate Preparation Products And Raw materials

Raw materials

4-Bromo-2-fluorobenzoic acid 4-BROMO-2-FLUOROBENZOYL CHLORIDE Methanol Iodomethane (TRIMETHYLSILYL)DIAZOMETHANE

Preparation Products

4-Cyano-2-fluorobenzyl alcohol METHYL 2-FLUORO-4-HYDROXYBENZOATE 4-BROMO-2-FLUOROBENZYL ALCOHOL 6-Bromo-3-hydroxy-benzo[b]thiophene-2-carboxylic acid methyl ester 3-Fluoro-4'-(trifluoroMethyl)-[1,1'-biphenyl]-4-carboxylic acid

2-(4-bromo-2-fluorophenyl)propan-2-ol

1of2

Methyl 4-bromo-2-fluorobenzoate Suppliers

Global( 277)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	21-33585366 13311639313	sales@shyrchem.com	China	807	55
Chengdu D-innovation Pharmaceutical Co.，LTD	028-85929779 18881048017	chenxuanruo@d-innovation.com	China	208	58
Wuhan hongde yuexin pharmaceutical technology co. LTD	027-83855395 13995685043	wuhanfudechem23@163.com	China	997	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	55
Chengdu D-innovation Pharmaceutical Co.，LTD	58
Wuhan hongde yuexin pharmaceutical technology co. LTD	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Adamas Reagent, Ltd.	59

View Lastest Price from Methyl 4-bromo-2-fluorobenzoate manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-07	Ethyl 2-fluoro-3-oxopentanoate 179232-29-2	1kg	99%min	20000kgs	HANGZHOU HAILAN CHEMICAL CO.,LTD.
2026-08-13	Methyl 4-bromo-2-fluorobenzoate 179232-29-2	1G	99%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2026-06-30	Methyl 4-bromo-2-fluorobenzoate 179232-29-2	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Ethyl 2-fluoro-3-oxopentanoate
179232-29-2
$0.00
99%min
HANGZHOU HAILAN CHEMICAL CO.,LTD.

Methyl 4-bromo-2-fluorobenzoate
179232-29-2
99%
Shenzhen Nexcon Pharmatechs Ltd.

Methyl 4-bromo-2-fluorobenzoate
179232-29-2
98.0%
Shaanxi Dideu New Materials Co. Ltd

Methyl 4-bromo-2-fluorobenzoate Spectrum

Methyl 4-bromo-2-fluorobenzoate(179232-29-2)¹HNMR

179232-29-2(Methyl 4-bromo-2-fluorobenzoate)Related Search:

Methyl 4-bromo-3-methylbenzoate 4-Bromo-2-fluorobenzoic acid 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 7 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-

4-amino-2-fluoro-N-methylbenzamide 4-Bromo-2-fluoro-N-methylbenzamide Enzalutamide Impurity 7 [2H6]-Enzalutamide N-desMethyl EnzalutaMide

Enzalutamide carboxylic acid 4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate

EnzalutaMide IMpurity Enzalutamide Enzalutamide

1of4

Methyl 4-bromo-2-fluorobenzoate Fluoro-4-bromobenzoate Enzalutamide Impurity 15 Enzalutamide EP Impurity C Benzoic acid, 4-bromo-2-fluoro-, methyl ester Methyl 4-bromo-2-fluorobenzoate(For export only) Methy 4-bromo-2-fluorobenzoate Enzalutamide ImpuritiesC Methyl 4-bromo-2-fluorobenzoate, 98% 2-Fluoro-4-bromobenzoic acid methyl ester 4-BROMO-2-FLUOROBENZOIC ACID METHYL ESTER Methyl 2-fluoro-4-bromobenzoate 179232-29-2 Aromatic Esters blocks Bromides Carboxes FluoroCompounds