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ChemicalBook >> CAS DataBase List >>2,4-Dichloro-8-methoxyquinazoline

2,4-Dichloro-8-methoxyquinazoline

2,4-Dichloro-8-methoxyquinazoline Structure
2,4-Dichloro-8-methoxyquinazoline structure
CAS No.
61948-60-5
Chemical Name:
2,4-Dichloro-8-methoxyquinazoline
Synonyms
2,4-Dichloro-8-methoxyquizoline;2,4-Dichloro-8-methoxyquinazoline;8-Methoxy-2,4-dichloroquinazoline;Quinazoline, 2,4-dichloro-8-methoxy-
CBNumber:
CB31504498
Molecular Formula:
C9H6Cl2N2O
Molecular Weight:
229.06
MDL Number:
MFCD09954882
MOL File:
61948-60-5.mol
MSDS File:
SDS
Last updated:2026-05-28 00:58:19
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2,4-Dichloro-8-methoxyquinazoline Properties

Melting point 157-159 °C
Boiling point 315.9±24.0 °C(Predicted)
Density 1.450
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -0.84±0.30(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2,4-Dichloro-8-methoxyquinazoline price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 305219 2,4-Dichloro-8-methoxyquinazoline 61948-60-5 250.00mg $21 2026-05-19 Buy
Matrix Scientific 305219 2,4-Dichloro-8-methoxyquinazoline 61948-60-5 1.00g $65 2026-05-19 Buy
Matrix Scientific 305219 2,4-Dichloro-8-methoxyquinazoline 61948-60-5 5.00g $191 2026-05-19 Buy
Synthonix D50839 2,4-Dichloro-8-methoxyquinazoline 97% 61948-60-5 100mg $19 2026-05-06 Buy
Synthonix D50839 2,4-Dichloro-8-methoxyquinazoline 97% 61948-60-5 250mg $25 2026-05-06 Buy
Product number Packaging Price Buy
305219 250.00mg $21 Buy
305219 1.00g $65 Buy
305219 5.00g $191 Buy
D50839 100mg $19 Buy
D50839 250mg $25 Buy

2,4-Dichloro-8-methoxyquinazoline Chemical Properties, Uses, Production

Chemical Properties

White flocculent solid

Uses

2,4-Dichloro-8-methoxyquinazoline has been used as a reactant for the preparation of p97 ATPase inhibitors.

Synthesis

2,4(1H,3H)-Quinazolinedione, 8-Methoxy-

62484-14-4

2,4-Dichloro-8-methoxyquinazoline

61948-60-5

General procedure for the synthesis of 2,4-dichloro-8-methoxyquinazoline from 8-methoxyquinazoline-2,4(1H,3H)-dione: 8-methoxyquinazoline-2,4-diol (5.5 g, 28.6 mmol) prepared in step 1 was mixed with phosphorochloridic acid chloride (25 ml) and the reaction was stirred under reflux conditions overnight. After completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and the pH was adjusted to 7-8 with sodium hydroxide solution.Subsequently, the aqueous layer was extracted with dichloromethane, the organic layers were combined and dried with anhydrous magnesium sulfate. After the solvent was removed by concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=5/1) to afford the target product 2,4-dichloro-8-methoxyquinazoline (2.1 g) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.83 (d, 1H), 7.65 (t, 1H), 7.34 (d, 1H), 4.09 (s, 3H).

References

[1] Patent: WO2016/200840, 2016, A1. Location in patent: Page/Page column 433
[2] Patent: WO2014/101113, 2014, A1. Location in patent: Paragraph 0165
[3] Patent: WO2014/101120, 2014, A1. Location in patent: Paragraph 0124
[4] Patent: WO2014/105666, 2014, A1. Location in patent: Paragraph 0116
[5] Patent: WO2014/101373, 2014, A1. Location in patent: Page/Page column 43; 44

2,4-Dichloro-8-methoxyquinazoline Preparation Products And Raw materials

Raw materials

2,4(1H,3H)-Quinazolinedione, 8-Methoxy-

Preparation Products

2,4-Dichloro-8-methoxyquinazoline Suppliers

Global Suppliers ( 112)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Shanghai Cuisen Pharmaceutical Technology Co., Ltd. 13472757003 yongnan.wang@cendrix.cn China 974 65
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2297 55
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai ChriChem Co., Ltd. 021-54880687 China 510 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Carbott PharmTech Inc. 56
Shangchem Co., Ltd. 52
Pure Chemistry Scientific Inc. 62
Shanghai Ennopharm Co., Ltd. 65
Shanghai Cuisen Pharmaceutical Technology Co., Ltd. 65
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Chiba Pharmaceutical Science and technology Co, Ltd. 55
SynAsst Chemical. 55
Shanghai ChriChem Co., Ltd. 55

View Latest Price from 2,4-Dichloro-8-methoxyquinazoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Dichloro-8-methoxyquinazoline pictures 2019-12-31 2,4-Dichloro-8-methoxyquinazoline
61948-60-5
 $1.00 1KG 99% 200kg Career Henan Chemical Co

2,4-Dichloro-8-methoxyquinazoline Spectrum

2,4-Dichloro-8-methoxyquinazoline(61948-60-5)1HNMR

61948-60-5 (2,4-Dichloro-8-methoxyquinazoline) Related Search:

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2,4-Dichloro-8-methoxyquinazoline 2,4-Dichloro-8-methoxyquizoline 8-Methoxy-2,4-dichloroquinazoline Quinazoline, 2,4-dichloro-8-methoxy- 61948-60-5 API intermediates