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ChemicalBook >> CAS DataBase List >>7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Structure
7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate structure
CAS No.
1053656-22-6
Chemical Name:
7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate
Synonyms
5,6-Dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-tert-butyl ester 2-ethyl ester;7-tert-butyl 2-ethyl 5;7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H);Ethyl 7-Boc-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine-2-carboxylate;7-tert-butyl 2-ethyl 5H,6H,7H,8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylate;Ethyl 7-BOC-3-broMo-5,6,7,8-tetrahydroiMidazo[1,2-a]pyrazine-2-carboxylate;7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate;7-Boc-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester;5,6-dihydroimidazo(1,2-a)pyrazine-2,7(8h)-dicarboxylic acid 7-tert-butyl 2-ethyl;7-O-tert-butyl 2-O-ethyl 6,8-dihydro-5H-imidazo[1,2-a]pyrazine-2,7-dicarboxylate
CBNumber:
CB31562371
Molecular Formula:
C14H21N3O4
Molecular Weight:
295.33
MDL Number:
MFCD10566312
MOL File:
1053656-22-6.mol
MSDS File:
SDS
Last updated:2026-05-28 01:00:31
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7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Properties

Boiling point 457.7±35.0 °C(Predicted)
Density 1.24
storage temp. 2-8°C
pka 4.06±0.20(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C14H21N3O4/c1-5-20-12(18)10-8-16-6-7-17(9-11(16)15-10)13(19)21-14(2,3)4/h8H,5-7,9H2,1-4H3
InChIKey UQNMISYKKAQDDT-UHFFFAOYSA-N
SMILES C12=NC(C(OCC)=O)=CN1CCN(C(OC(C)(C)C)=O)C2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 076238 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo-[1,2-a]pyrazine-2,7(8H)-dicarboxylate 1053656-22-6 1.00g $61 2026-05-18 Buy
Matrix Scientific 076238 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo-[1,2-a]pyrazine-2,7(8H)-dicarboxylate 1053656-22-6 5.00g $296 2026-05-18 Buy
Matrix Scientific 076238 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo-[1,2-a]pyrazine-2,7(8H)-dicarboxylate 1053656-22-6 10.00g $557 2026-05-18 Buy
Synthonix B57920 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 97% 1053656-22-6 100mg $61 2026-05-06 Buy
Synthonix B57920 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 97% 1053656-22-6 250mg $67 2026-05-06 Buy
Product number Packaging Price Buy
076238 1.00g $61 Buy
076238 5.00g $296 Buy
076238 10.00g $557 Buy
B57920 100mg $61 Buy
B57920 250mg $67 Buy

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Chemical Properties, Uses, Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE

77112-52-8

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

1053656-22-6

Method A - Step b: Preparation of 7-tert-butyl-2-ethyl-5,6-dihydroimidazo[1,2-a]pyrazine-2-dicarboxylate [0080] In 500 mL of ethanol, ethyl imidazo[1,2-a]pyrazine-2-carboxylate (1 g, 5.2 mmol), di-tert-butyl dicarbonate (Boc2O, 3.0 g, 18 mmol), and 200 mg of 10% Pd/C (50% wetted) were added. The reaction mixture was stirred at room temperature for 24 h under hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent being a solvent mixture of dichloromethane and methanol (CH2Cl2:MeOH = 50:1). Ethyl 7-Boc-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate was finally obtained as a yellow oil (0.973 g, 63% yield). 1H NMR (400 MHz, CDCl3) δ 7.51 (s, 1H), 4.68 (s, 2H), 4.30 (q, J = 7.1 Hz, 2H), 4.00 (t, J = 5.2 Hz, 2H), 3.82 (t, J = 5.2 Hz, 2H), 1.43 (s, 9H), 1.21 (t, J = 7.1 Hz, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 10, p. 2300 - 2304
[2] Patent: WO2014/113191, 2014, A1. Location in patent: Paragraph 0079; 0080
[3] Patent: US2009/186899, 2009, A1. Location in patent: Page/Page column 45-47
[4] Patent: WO2009/90055, 2009, A1. Location in patent: Page/Page column 135

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Ethyl imidazo[1,2-a]pyrazine-2-carboxylate Hydrogen Ethanol Activated carbon
Palladium

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Preparation Products

tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Suppliers

Global Suppliers ( 91)
Supplier Tel Email Country ProdList Advantage
Shanghai Anmike Chemical Co. Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 9988 55
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
China Langchem Inc. 0086-21-58956006 China 7798 57
Wuhan ariel chemical Co., LTD. 18986259541 18986259541 sales@3stc.com China 3828 58
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Supplier Advantage
Shanghai Anmike Chemical Co. Ltd. 55
Capot Chemical Co., Ltd 66
Shangchem Co., Ltd. 52
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
China Langchem Inc. 57
Wuhan ariel chemical Co., LTD. 58
Hangzhou Sage Chemical Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58

View Latest Price from 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate pictures 2020-01-15 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate
1053656-22-6
 $1.00 1g 99% 1000KGS Career Henan Chemical Co

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate Spectrum

7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate(1053656-22-6)1HNMR

1053656-22-6 (7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate) Related Search:

Methyl 7-nitrobenzo[b]thiophene-2-carboxylate Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate N-tert-Butoxycarbonyl-2-aminomethyl-imidazole-4-carboxylic acid methyl ester 2-((tert-Butoxycarbonylamino)methyl)-1H-imidazole-5-carboxylic acid 5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine-2-carboxylic acid
7-tert-butyl 2-ethyl 3-bromo-5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5,6,7,8-tetrahydro-, methyl ester (9CI)

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7-O-tert-butyl 2-O-ethyl 6,8-dihydro-5H-imidazo[1,2-a]pyrazine-2,7-dicarboxylate Imidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylic acid, 5,6-dihydro-, 7-(1,1-dimethylethyl) 2-ethyl ester 5,6-Dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylic acid 7-tert-butyl 2-ethyl ester Ethyl 7-Boc-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine-2-carboxylate 7-tert-butyl 2-ethyl 5 Ethyl 7-BOC-3-broMo-5,6,7,8-tetrahydroiMidazo[1,2-a]pyrazine-2-carboxylate Ethyl 7-(tert-Butoxycarbonyl)-3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H) 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 7-tert-butyl 2-ethyl 5H,6H,7H,8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylate 5,6-dihydroimidazo(1,2-a)pyrazine-2,7(8h)-dicarboxylic acid 7-tert-butyl 2-ethyl ENCHEM IMIDAZO[1,2-A]PYRAZINE-2,7(8H)-DICARBOXYLICACID, 5,6-DIHYDRO-, 7-(1,1-DIMETHYLETHYL) 2-ETHYL ESTER 1053656-22-6 7-(1,1-Dimethylethyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 7-Boc-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester 5,6-Dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-tert-butyl ester 2-ethyl ester 1053656-22-6 CHIRAL CHEMICALS