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N-Methylolacrylamide

CAS No.
924-42-5
Chemical Name:
N-Methylolacrylamide
Synonyms
N-(HYDROXYMETHYL)ACRYLAMIDE;METHYLOLACRYLAMIDE;N-MAN;N-MAN PC;N-Methanolacrylamide;HINT;NM-AMD;PRKCNH1;uraminet80;Rocagil BT
CBNumber:
CB3182194
Molecular Formula:
C4H7NO2
Molecular Weight:
101.1
MDL Number:
MFCD00004597
MOL File:
924-42-5.mol
MSDS File:
SDS
Last updated:2026-06-24 18:39:39
Product description Number Pack Size Price
N-(Hydroxymethyl)acrylamide (48% aqueous solution) (stabilised with hydroquinone monomethyl ether) for synthesis 8.20675 100mL $44.1
N-(Hydroxymethyl)acrylamide solution 48 wt. % in H2O 245801 100g $98.1
N-(Hydroxymethyl)acrylamide solution 48 wt. % in H2O 245801 1kg $171
N-(Hydroxymethyl)acrylamide (48% aqueous solution) (stabilised with hydroquinone monomethyl ether) for synthesis 8.20675 1L $69.2
N-(Hydroxymethyl)acrylamide >98.0%(T) M0574 25g $27
More product size

N-Methylolacrylamide Properties

Melting point 74-75°C
Boiling point 277°C(lit.)
Density 1.082 g/mL at 20 °C
vapor pressure 31 hPa (25 °C)
refractive index n20/D 1.413
Flash point 100°C
storage temp. Store at <= 20°C.
solubility Chloroform (Slightly), Methanol (Slightly)
pka 13.25±0.10(Predicted)
form Solid
color White to Off-White
Specific Gravity 1.074
PH 6.0-7.0 (H2O, 20°C)
Water Solubility <0.1 g/100 mL at 20.5 ºC
BRN 506646
Stability Light Sensitive, Moisture Sensitive
InChI 1S/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7)
InChIKey CNCOEDDPFOAUMB-UHFFFAOYSA-N
SMILES OCNC(=O)C=C
LogP -1.81 at 20℃ and pH7
Toxicology and Carcinogenesis Toxicology and Carcinogenesis Studies of N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats and B6C3F1 Mice
Substances of Very High Concern (SVHC) Candidate List N-(hydroxymethyl)acrylamide (924-42-5)
FDA 21 CFR 175.105; 176.170; 176.180;177.1010; 177.2260
Indirect Additives used in Food Contact Substances N-METHYLOLACRYLAMIDE
CAS DataBase Reference 924-42-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII W8W68JL80Q
Proposition 65 List n-Methylolacrylamide
NIST Chemistry Reference 2-Propenamide, n-(hydroxymethyl)-(924-42-5)
IARC 3 (Vol. 60) 1994
EPA Substance Registry System N-Methylolacrylamide (924-42-5)
UNSPSC Code 12352111
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H317-H340-H350-H361-H372-H373
Precautionary statements  P202-P260-P264-P280-P301+P310-P302+P352
target organs Peripheral nervous system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,T
Risk Statements  22-36/37/38-62-48/20/21/22-43-46-45
Safety Statements  26-45-36/37-53
RIDADR  2810
WGK Germany  3
RTECS  AS3600000
TSCA  TSCA listed
HazardClass  4.1
PackingGroup  III
HS Code  29241990
Storage Class 6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Carc. 1B
Muta. 1B
Repr. 2
Skin Sens. 1
STOT RE 1
STOT RE 2 Oral
Hazardous Substances Data 924-42-5(Hazardous Substances Data)
REACH Registrations Active
NFPA 704
0
3 0

N-Methylolacrylamide price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.20675 N-(Hydroxymethyl)acrylamide (48% aqueous solution) (stabilised with hydroquinone monomethyl ether) for synthesis 924-42-5 100mL $44.1 2026-04-30 Buy
Sigma-Aldrich 245801 N-(Hydroxymethyl)acrylamide solution 48 wt. % in H2O 924-42-5 100g $98.1 2026-04-30 Buy
Sigma-Aldrich 245801 N-(Hydroxymethyl)acrylamide solution 48 wt. % in H2O 924-42-5 1kg $171 2026-04-30 Buy
Sigma-Aldrich 8.20675 N-(Hydroxymethyl)acrylamide (48% aqueous solution) (stabilised with hydroquinone monomethyl ether) for synthesis 924-42-5 1L $69.2 2024-03-01 Buy
TCI Chemical M0574 N-(Hydroxymethyl)acrylamide >98.0%(T) 924-42-5 25g $27 2026-04-30 Buy
Product number Packaging Price Buy
8.20675 100mL $44.1 Buy
245801 100g $98.1 Buy
245801 1kg $171 Buy
8.20675 1L $69.2 Buy
M0574 25g $27 Buy

N-Methylolacrylamide Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

N-(Hydroxymethyl)acrylamide can be used as:

  • A monomer in the development of polymer gel dosimeters specifically designed for radiation therapy applications. The incorporation of NHMA enhances the sensitivity of the dosimeter to radiation doses.
  • A monomer in the development of thermo-responsive polymeric gates, which exhibits thermo-responsive behavior. The incorporation of NHMA enhances the overall properties of the polymer, allowing for better control over the release mechanisms in response to temperature changes.
  • A key monomer in the synthesis of double-hydrophilic and amphiphilic block glycopolymers, contributing to their self-assembly properties, biocompatibility, and functionalization potential. These characteristics make NHMA-based glycopolymers valuable for various biomedical applications, including drug delivery systems, biosensors, and tissue engineering.

Definition

ChEBI: N-Methylolacrylamide is a secondary carboxamide.

General Description

A colorless or yellow aqueous solution.

Air & Water Reactions

Soluble in water.

Reactivity Profile

N-Methylolacrylamide may be sensitive to prolonged exposure to light. Polymerization and generation of heat and flames may occur on exposure to to heat or contaminants. Incompatible with strong oxidizers.

Fire Hazard

Literature sources indicate that N-Methylolacrylamide is nonflammable.

Synthesis

(1), the acrylamide is added to the reaction kettle containing solvent acetone, the polymerization blocking agent is added, and the temperature is raised to 4245;

(2), adding catalyst sodium methanol, adjusting the pH value in the reaction solution to 8.88;

(3), adding formaldehyde, adjusting the pH of the reaction solution to 8.5, and reacting at constant temperature for 1 hour;

(4), add phthalic acid, adjust its reaction solution pH to 7.2;

(5), cooling, crystallization, filtration to get the finished product N-hydroxymethacrylamide.

N-Methylolacrylamide Preparation Products And Raw materials

Global( 455)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd
+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5220 58
Hebei Chuanghai Biotechnology Co., Ltd
+8615531151365 mina@chuanghaibio.com China 18126 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651 admin@zlchemi.com China 3692 58
HebeiShuoshengImportandExportco.,Ltd
+86-18532138899 L18532138899@163.com China 939 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
+86-15225627621 +86-13213167925 jiuyitime@fdachem.com China 16511 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763 info@tnjchem.com China 2988 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58

View Lastest Price from N-Methylolacrylamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Methylolacrylamide pictures 2026-07-02 N-Methylolacrylamide
924-42-5
$2.00-6.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
N-Methylolacrylamide pictures 2026-06-30 N-Methylolacrylamide
924-42-5
1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
N-Methylolacrylamide  pictures 2026-05-28 N-Methylolacrylamide
924-42-5
$1.00 10kg 99 % 10000kg Hebei Chuanghai Biotechnology Co,.LTD
N-(Hydroxymethyl)acrylamide solution 48 wt. % in H2O N-METHYLOLACRYLAMIDE n-(hydroxymethyl)-2-propenamide uraminet80 Yuramin T 80 METHYLOLACRYLAMIDE Methylolacrylamidesolution N-MAN N-(HYDROXYMETHYL)ACRYLAMIDE SOLUTION, ST AB., ~48% IN H2O N-(HYDROXYMETHYL)ACRYLAMIDE, 48 WT. % SO LUTION IN WATER n-(hydroxymethyl)acrylamide solution N-hydroxymethyl-propenamide Rocagil BT N-MAN PC N-(Hydroxymethyl)acrylamide 2-Propenamide,N-(hydroxymethyl)- Acrylamide, N-(hydroxymethyl)- Monomethylolacrylamide n-(hydroxymethyl)-2-propenamid n-(hydroxymethyl)-acrylamid NCI-C60333 NM-AMD N-Methyloacrylamide n-methylolacrylamide(48%inwater) Uramine T 80 N-(Hydroxymethyl)acrylamide> N-Methylol Alflutinib Impurity 4 N-(Hydroxymethyl)acrylamide solution HINT PRKCNH1 N-(Hydroxymethyl)acrylamide 100 μg/mL in Acetonitrile N-Hydroxymethyl acrylamide(NMA) N-(HYDROXYMETHYL)ACRYLAMIDE N-Methanolacrylamide 924-42-5 942-42-5 C4H7O2N CH2CHCONHCH2OH H2CCCH3CONHOH AMINE fine chemicals Acrylamide and Methacrylamide Acrylic Monomers Monomers 924-42-5