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N-Nitrosomorpholine

N-Nitrosomorpholine structure

CAS No.: 59-89-2

Chemical Name:: N-Nitrosomorpholine

Synonyms: NMOR;4-Nitrosomorpholine;NSC 139;nci-c02164;M2-Impurity D;N-Nitrosomorfolin;NITROSOMORPHOLINE;N-Nitrosomorpholin;n-nitroso-morpholin;4-nitroso-morpholin

CBNumber:: CB3185221

Molecular Formula:: C4H8N2O2

Molecular Weight:: 116.12

MDL Number:: MFCD00039710

MOL File:: 59-89-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:51:46

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N-Nitrosomorpholine Properties

Melting point	29°C
Boiling point	225℃
Density	1.2829 (rough estimate)
refractive index	1.4880 (estimate)
Flash point	29 °C
storage temp.	2-8°C
Water Solubility	Completely soluble in water
solubility	DMSO : 100 mg/mL (861.18 mM)
form	<29°C Solid,>29°C Liquid
pka	-5.72±0.20(Predicted)
color	White or Colorless to Yellow
Merck	14,6640
Henry's Law Constant	3.9×10² mol/(m³Pa) at 25℃, Mirvish et al. (1976)
Stability	Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents. Refrigerate, store in the dark.
Major Application	pharmaceutical (small molecule)
InChI	1S/C4H8N2O2/c7-5-6-1-3-8-4-2-6/h1-4H2
InChIKey	ZKXDGKXYMTYWTB-UHFFFAOYSA-N
SMILES	O=NN1CCOCC1
EWG's Food Scores	1-3
FDA UNII	3L25FO7FN7
Proposition 65 List	n-Nitrosomorpholine
IARC	2B (Vol. 17, Sup 7) 1987
EPA Substance Registry System	N-Nitrosomorpholine (59-89-2)
UNSPSC Code	77101502
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H351

Precautionary statements

P201-P301+P310+P330

Hazard Codes

Xn,T,F

Risk Statements

22-40-39/23/24/25-23/24/25-11

Safety Statements

36/37-45-16-7

RIDADR

UN 2810 6.1/PG 3

WGK Germany

RTECS

QE7525000

HS Code

2934.99.9001

HazardClass

6.1(b)

PackingGroup

III

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Carc. 2

Hazardous Substances Data

59-89-2(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 282 mg/kg (Druckrey)

NFPA 704

	0
2		0

N-Nitrosomorpholine price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000822	Molsidomine impurity B European Pharmacopoeia (EP) Reference Standard	59-89-2	10 mg	$164	2026-04-30	Buy
Sigma-Aldrich	N7382	Nitrosomorpholine	59-89-2	1ml	$179	2026-04-30	Buy
Sigma-Aldrich	N7382	Nitrosomorpholine	59-89-2	5ml	$611	2026-04-30	Buy
Sigma-Aldrich	CRM40485	n-Nitrosomorpholine solution certified reference material, 5000 μg/mL in methanol, ampule of 1 mL		1 mL	$54.5	2026-04-30	Buy
Sigma-Aldrich	68359	N-Nitrosomorpholine certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland	59-89-2	50 mg	$211	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0000822	10 mg	$164	Buy
N7382	1ml	$179	Buy
N7382	5ml	$611	Buy
CRM40485	1 mL	$54.5	Buy
68359	50 mg	$211	Buy

N-Nitrosomorpholine Chemical Properties, Uses, Production

Chemical Properties

yellow crystals or gold liquid

Uses

N-Nitrosomorpholine, a frequently used genotoxic model carcinogen. Toxicogenomic analysis of N-Nitrosomorpholine induced changes in rat liver.

Uses

Solvent for polyacrylonitrile; present during rubber manufacturing

Definition

ChEBI: A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.

Synthesis Reference(s)

Synthetic Communications, 22, p. 2607, 1992 DOI: 10.1080/00397919208021659

General Description

Yellow crystals. Golden liquid with many crystals at 68°F.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-NITROSOMORPHOLINE is incompatible with strong oxidizing agents .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOMORPHOLINE emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for N-NITROSOMORPHOLINE are not available; however, N-NITROSOMORPHOLINE is probably combustible.

Biochem/physiol Actions

Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Carcinogenicity

N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

N-Nitrosomorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

N-NitrosoMorpholine-d4

N-Nitrosomorpholine Suppliers

Global Suppliers ( 156)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Shanghai civi chemical technology co.,Ltd	86-21-34053660	sale@labgogo.com	China	9853	52
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shanghai Longsheng chemical Co.,Ltd.	59
Chemsky（shanghai）International Co.,Ltd.	50
Syntechem Co.,Ltd	57
Sichuan Kulinan Technology Co., Ltd	57
BOC Sciences	65
Shanghai civi chemical technology co.,Ltd	52
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55

View Latest Price from N-Nitrosomorpholine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	N-Nitrosomorpholine 59-89-2	$29.00		≥98%	10g	TargetMol Chemicals Inc.
	2026-03-12	N-nitrosomorpholine 59-89-2		10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD

N-Nitrosomorpholine
59-89-2
$29.00
≥98%
TargetMol Chemicals Inc.

N-nitrosomorpholine
59-89-2
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

N-Nitrosomorpholine Spectrum

N-NITROSOMORPHOLINE(59-89-2)¹HNMR

59-89-2 (N-Nitrosomorpholine) Related Search:

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4-nitroso-morpholin Morpholine, N-nitroso- Morpholine,4-nitroso- N-Nitrosomorpholine 100mg [59-89-2] NSC 139 nci-c02164 nitrosomorpholineisopac N-Nitrosomorfolin N-Nitrosomorpholin n-nitroso-morpholin NITROSOMORPHOLINE N-NITROSOMORPHOLINE, 1X1ML, MEOH, 5000UG /ML n-nitrosomorpholine solution N-Nitrosomorpholine @5.0 mg/mL in MeOH Molsidomine impurity B CRS N-Nitrosomorpholine@100 μg/mL in Dichloromethane N-Nitrosomorpholine> N-NitrosomorpholineSolution,5,000mg/L,1ml N-Nitrosomorpholine,inhibit,N Nitrosomorpholine,Inhibitor,NNitrosomorpholine 4-Nitrosomorpholine 0.1 mg/ml in Methanol 4-Nitrosomorpholine 1.0 mg/ml in Methanol N-nitroso-morpholine, NMOR3,7 N-Nitrosomorpholine 10.0 μg/ml Methanol M2-Impurity D N-Nitrosomorpholine, 10 mM in DMSO N-Nitrosomorpholine (Standard) 4-Nitrosomorpholine NMOR N-Nitrosomorpholine 59-89-2 Mutagenesis Research Chemicals Nitric Oxide Reagents Nitrosamine pharmacetical Alpha Sort N NA - NI N-OAlphabetic Volatiles/ Semivolatiles