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ChemicalBook >> CAS DataBase List >>2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Structure
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine structure
CAS No.
74901-69-2
Chemical Name:
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
Synonyms
7-dihydrothieno[3;tert-butyl 3-BroMo-6;Nerandomilast Impurity 105;2,4-Dichloro-6,7-dihydro-thieno[3,2-;2,4-dichloro-6H,7H-thieno[3,2-d]pyrimidine;2,4-Dichloro-6,7-dihyrothieno[3,2-d]pyrimidine;2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine;2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidi...;Thieno[3,2-d]pyrimidine, 2,4-dichloro-6,7-dihydro-;2, 4-dichloro-6, 7-dihydrothiophene [3, 2-d] pyrimidine
CBNumber:
CB31856090
Molecular Formula:
C6H4Cl2N2S
Molecular Weight:
207.08
MDL Number:
MFCD11109461
MOL File:
74901-69-2.mol
TDS File:
TDS
Last updated:2026-07-24 07:50:49
Product description Number Pack Size Price
2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 118918 250.00mg $195
2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 118918 1.00g $486
2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 98% D42071 250mg $25
2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 98% D42071 1g $30
2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 98% D42071 5g $80
More product size
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2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Properties

Boiling point 329.4±42.0 °C(Predicted)
Density 1.613±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka -2.53±0.20(Predicted)
Appearance Off-white to light yellow Solid
InChI InChI=1S/C6H4Cl2N2S/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H2
InChIKey CUVQFHMQHBMFCI-UHFFFAOYSA-N
SMILES C1(Cl)=NC(Cl)=C2SCCC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
REACH Registrations Active

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 118918 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 74901-69-2 250.00mg $195 2026-05-18 Buy
Matrix Scientific 118918 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 74901-69-2 1.00g $486 2026-05-18 Buy
Synthonix D42071 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 98% 74901-69-2 250mg $25 2026-05-06 Buy
Synthonix D42071 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 98% 74901-69-2 1g $30 2026-05-06 Buy
Synthonix D42071 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 98% 74901-69-2 5g $80 2026-05-06 Buy
Product number Packaging Price Buy
118918 250.00mg $195 Buy
118918 1.00g $486 Buy
D42071 250mg $25 Buy
D42071 1g $30 Buy
D42071 5g $80 Buy

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Chemical Properties,Uses,Production

Uses

2,4-Dichloro-6,7-dihydrothiophene[3,2-D]pyrimidine is a pyrimidine organic compound that can be used as a pharmaceutical intermediate.

Synthesis

6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol

913581-92-7

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

74901-69-2

General procedure for the synthesis of 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine (VII) from 6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol (VI): 2.4 g (14.1 mmol) of 6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol (VI) was suspended in 14 mL of phosphorus oxychloride and added with 4.5 mL (28.2 mmol) of diethylaniline and the mixture was stirred at 80 °C for 22 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into ice water, the precipitate formed was collected by filtration and washed with cold water. The resulting precipitate was dissolved in dichloromethane and the water was removed by a phase separator. The organic phase was concentrated to dryness under reduced pressure to give 2.5 g of the target product VII in 85% yield.

References

[1] Organic Process Research and Development, 2016, vol. 20, # 5, p. 982 - 988
[2] Patent: WO2006/111549, 2006, A1. Location in patent: Page/Page column 61; 59; 65; 68; 69; 72; 74; 76; 84
[3] Patent: US2007/259846, 2007, A1. Location in patent: Page/Page column 30; 31
[4] Patent: WO2013/26797, 2013, A1. Location in patent: Page/Page column 24-25
[5] Patent: US2013/150341, 2013, A1. Location in patent: Paragraph 0364; 0365; 0366; 0367

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Preparation Products And Raw materials

Raw materials

6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol

Preparation Products

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Suppliers

Global( 163)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-17392587031 1059@dideu.com China 9996 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 info@afinechem.com China 15079 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Shaanxi Dideu Medichem Co. Ltd 		58
AFINE CHEMICALS LIMITED 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine pictures 2026-07-24 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
74901-69-2
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine pictures 2025-06-25 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
74901-69-2
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine pictures 2019-07-06 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
74901-69-2
$40.00-1500.00 1G 98% 100kg Career Henan Chemical Co

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Spectrum

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine(74901-69-2)1HNMR

74901-69-2(2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine)Related Search:

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2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 2,4-Dichloro-6,7-dihyrothieno[3,2-d]pyrimidine 7-dihydrothieno[3 tert-butyl 3-BroMo-6 2,4-Dichloro-6,7-dihydro-thieno[3,2- 2,4-dichloro-6H,7H-thieno[3,2-d]pyrimidine 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidi... Thieno[3,2-d]pyrimidine, 2,4-dichloro-6,7-dihydro- 2,4-Dichloro-6,7-dihydrothieno[3,2-D]pyrimidine 5,5-dioxide FAVORITES COMPARE 2,4-DICHLORO-6,7-DIHYDROTHIENO[3,2-D]PYRIMIDINE 74901-69-2 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine ISO 9001：2015 REACH 2, 4-dichloro-6, 7-dihydrothiophene [3, 2-d] pyrimidine Nerandomilast Impurity 105 74901-69-2 Heterocycle-Pyrimidine series CHIRAL CHEMICALS