3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
- CAS No.
- 2267-40-5
- Chemical Name:
- 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
- Synonyms
- Benzoic acid,3-(chlo;3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID;3-(Chlorosulphonyl)-4-fluorobenzoic acid;Benzoic acid,3-(chlorosulfonyl)-4-fluoro-;5-Carboxy-2-fluorobenzenesulphonyl chloride;2-fluoro-5-carboxybenzenesulphonyl chloride;3-(chlorosulfonyl)-4-fluorobenzoic acid(SALTDATA: FREE)
- CBNumber:
- CB3196054
- Molecular Formula:
- C7H4ClFO4S
- Molecular Weight:
- 238.62
- MDL Number:
- MFCD03030336
- MOL File:
- 2267-40-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-chlorosulfonyl-4-fluoro-benzoic acid AldrichCPR | CDS011580 | 100 mg | $197 |
| 3-(Chlorosulphonyl)-4-fluorobenzoic acid >98% | PC49191 | 5g | $21 |
| 3-(Chlorosulphonyl)-4-fluorobenzoic acid >98% | PC49191 | 25g | $47 |
| 3-(Chlorosulphonyl)-4-fluorobenzoic acid >98% | PC49191 | 100g | $176 |
| 3-(Chlorosulphonyl)-4-fluorobenzoic acid >98% | PC49191 | 500g | $872 |
| More product size | |||
| Melting point | 147-148℃ |
|---|---|
| Boiling point | 388.6±27.0 °C(Predicted) |
| Density | 1.670±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder |
| pka | 2.94±0.10(Predicted) |
| color | White/off-white |
| InChI | InChI=1S/C7H4ClFO4S/c8-14(12,13)6-3-4(7(10)11)1-2-5(6)9/h1-3H,(H,10,11) |
| InChIKey | LZGZJLJZSAGDKR-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(F)C(S(Cl)(=O)=O)=C1 |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| WGK Germany | WGK 3 |
| HS Code | 2916399090 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS011580 | 3-chlorosulfonyl-4-fluoro-benzoic acid AldrichCPR | 100 mg | $197 | 2026-04-30 | Buy | |
| Apolloscientific | PC49191 | 3-(Chlorosulphonyl)-4-fluorobenzoic acid >98% | 2267-40-5 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC49191 | 3-(Chlorosulphonyl)-4-fluorobenzoic acid >98% | 2267-40-5 | 25g | $47 | 2026-06-04 | Buy |
| Apolloscientific | PC49191 | 3-(Chlorosulphonyl)-4-fluorobenzoic acid >98% | 2267-40-5 | 100g | $176 | 2026-06-04 | Buy |
| Apolloscientific | PC49191 | 3-(Chlorosulphonyl)-4-fluorobenzoic acid >98% | 2267-40-5 | 500g | $872 | 2026-06-04 | Buy |
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Chemical Properties,Uses,Production
Synthesis
456-22-4
2267-40-5
Example 2: Synthesis of 2-fluoro-5-(4-methoxybenzoyl)-benzenesulfonamide; 4-fluorobenzoic acid (8 g, 57 mmol) was slowly added to chlorosulfonic acid (58 g, 498 mmol), followed by sodium chloride (10 g, 169 mmol). After the addition was completed, the reaction mixture was heated at 160°C for 5 hours. After completion of the reaction, the reaction mixture was cooled and slowly poured into ice water. The precipitated white solid precipitate was collected by filtration and redissolved in ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was ground with hexane to give 7 g (51% yield) of the target product as a white solid.1H NMR (CDCl3): δ 8.78 (m, 1H), 8.52 (m, 1H), 7.5 (t, 1H).MS (m/z): 308 (M-1).
References
[1] Patent: US2004/2492, 2004, A1. Location in patent: Page/Page column 48-49
[2] Patent: WO2009/118292, 2009, A1. Location in patent: Page/Page column 42-43
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 13, p. 2017 - 2034
[4] Bioorganic and medicinal chemistry, 2002, vol. 10, # 3, p. 639 - 656
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 5, p. 1596 - 1609
3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3970 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| CD Chemical Group Limited | +86-13651442114 | info@codchem.com | China | 17253 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
View Lastest Price from 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 3-(chlorosulfonyl)-4-fluorobenzoic acid
2267-40-5
|
5mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-12-20 | 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
2267-40-5
|
$1.00 | 1KG | 97-99% | 1000KGS | Career Henan Chemical Co |
-
- 3-(chlorosulfonyl)-4-fluorobenzoic acid
2267-40-5
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-CHLOROSULFONYL-4-FLUORO-BENZOIC ACID
2267-40-5
- $1.00
- 97-99%
- Career Henan Chemical Co
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