Atropic acid
- CAS No.
- 492-38-6
- Chemical Name:
- Atropic acid
- Synonyms
- 2-PHENYLACRYLIC ACID;2-Phenylpropenoic acid;NSC 20987;ATROPIC ACID;Atropic Acid >10029 ATROPIC ACID;Cinacalcet ImpurityI;Α-PHENYLACRYLIC ACID;Atropic acid，492-38-6;Ipratropium Impurity D
- CBNumber:
- CB3224700
- Molecular Formula:
- C9H8O2
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD00046531
- MOL File:
- 492-38-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 106-107° |
|---|---|
| Boiling point | bp ~267° with partial decompn |
| Density | 1.0061 (rough estimate) |
| refractive index | 1.5049 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.86±0.11(Predicted) |
| color | White to Off-White |
| Water Solubility | 1.3g/L(20 ºC) |
| Merck | 14,874 |
| Stability | Light Sensitive |
| Major Application |
pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C9H8O2/c1-7(9(10)11)8-5-3-2-4-6-8/h2-6H,1H2,(H,10,11) |
| InChIKey | ONPJWQSDZCGSQM-UHFFFAOYSA-N |
| SMILES | OC(=O)C(=C)c1ccccc1 |
| CAS DataBase Reference | 492-38-6(CAS DataBase Reference) |
| FDA UNII | TW16UA35S0 |
| NIST Chemistry Reference | Benzeneacetic acid, «alpha»-methylene-(492-38-6) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-methylene- (492-38-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| target organs | Respiratory system |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | WGK 3 |
| HS Code | 29163990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| REACH Registrations | Active |
Atropic acid price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BP1232 | Ipratropium bromide Impurity D British Pharmacopoeia (BP) Reference Standard | 492-38-6 | 25 mg | $294 | 2026-04-30 | Buy |
| TCI Chemical | A2390 | Atropic Acid >93.0%(GC) | 492-38-6 | 5g | $49 | 2026-04-30 | Buy |
| TCI Chemical | A2390 | Atropic Acid >93.0%(GC) | 492-38-6 | 25g | $170 | 2026-04-30 | Buy |
| Biosynth | FP142394 | 2-Phenylacrylic acid | 492-38-6 | 0.05kg | $150 | 2026-06-04 | Buy |
| Biosynth | FP142394 | 2-Phenylacrylic acid | 492-38-6 | 0.025kg | $150 | 2026-06-04 | Buy |
Atropic acid Chemical Properties, Uses, Production
Chemical Properties
White to Off-White Solid.
Uses
Atropic acid is an Impurity of Ipratropium bromide and Atropine Sulfate. Atropic acid and β,β-dimethylatropic acid are plant growth regulators.
Preparation
The synthesis of atropic acid involves several steps. Firstly, tropic acid is oxidized with hot KMnO4 to form benzoic acid. Secondly, tropic acid reacted with HBr to produce C9H9O2Br. Thirdly, C9H9O2Br is reacted with alcoholic KOH to yield atropic acid, C9H8O2. Finally, atropic acid is catalytically hydrogenated to form hydratropic acid, C9H10O2.
Reactions
Atropic acid is formed by the dehydration of tropic acid. Hence addition of water to atropic acid gives tropic acid.
Atropic acid, on oxidation yields benzoic acid. The formation of benzoic acid reveals that atropic acid and tropic acid contain atleast one benzene nucleus with a side chain containing carboxylic acid in their structure.
As atropic acid is an unsaturated acid it mean atropic acid may be either structure (I) or (II) .
Hence, the structure (II) is atropic acid which is confirmed by oxidation with KMnO4 to form phenylglyoxal.
Atropic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
| Zhejiang Karry Pharmachem Co., Ltd. | 19157666807 | info@karrypharma.com | China | 37 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451683 15021268886 | sales@arborchemical.com | China | 765 | 55 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 | 3008233746@qq.com | China | 9968 | 12 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
Related articles
- The synthesis routes and applications of atropic acid
- Atropic acid has various physiological effects and is synthesized from components such as lithium dibenzylamide.
- Feb 7,2025
- Ipratropium bromide Impurity D
- Ipratropium bromide Impurity D Synonyms: 2-Phenylpropenoic Acid,Ipratropium Bromide Imp. D (EP), Ipratropium Impurity D, Atro....
- Jul 26,2023
View Latest Price from Atropic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-26 | Atropic acid
492-38-6
|
$39.00-118.00 | 99.56% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-08-07 | Atropic acid
492-38-6
|
$1.00-100.00 | 1KG | 95% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-04-22 | Atropic acid
492-38-6
|
$39.00-118.00 | 99.56% | 10g | TargetMol Chemicals Inc. |
-
- Atropic acid
492-38-6
- $39.00-118.00
- 99.56%
- TargetMol Chemicals Inc.
-
- Atropic acid
492-38-6
- $1.00-100.00
- 95%
- Shaanxi Dideu Medichem Co. Ltd
-
- Atropic acid
492-38-6
- $39.00-118.00
- 99.56%
- TargetMol Chemicals Inc.
