Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol
- CAS No.
- 136171-87-4
- Chemical Name:
- Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol
- Synonyms
- Lobetyol;4,12-Tetradecadiene-8,10-diyne-1,6,7-triol;Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol
- CBNumber:
- CB32289152
- Molecular Formula:
- C14H18O3
- Molecular Weight:
- 234.29
- MDL Number:
- MFCD21333772
- MOL File:
- 136171-87-4.mol
Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol Chemical Properties,Uses,Production
Uses
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity[1][2]. Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
Lobetyol (0-10 mg/kg, Once per 3 days) suppresses tumor growth in MKN45 nude models[1].
| Animal Model: | BALB/C nude mice (6 weeks-old, injected intraperitoneally with MKN45 cells)[1] |
| Dosage: | 0, 2, 5, 10 mg/kg |
| Administration: | Once per 3 days |
| Result: | Suppressed tumor growth in MKN45 nude models. The protein levels of Ki67 in MKN45 cells were significantly decreased. Meanwhile, cleaved-caspase-3 positive MKN45 cells were found increased with the tendency of lobetyol concentrations in the study in vivo. |
IC 50
Bax; Bcl-2
References
[1] Shen J, et al. Lobetyol activate MAPK pathways associated with G1/S cell cycle arrest and apoptosis in MKN45 cells in vitro and in vivo. Biomed Pharmacother. 2016 Jul;81:120-127. DOI:10.1016/j.biopha.2016.03.046
[2] Xie Q, et al. The in vitro/in vivo metabolic pathways analysis of lobetyol, lobetyolin, and lobetyolinin, three polyacetylenes from Codonopsis Radix, by UHPLC-Q/TOF-MS and UHPLC-MS/MS. J Pharm Biomed Anal. 2023 Jan 20;223:115140. DOI:10.1016/j.jpba.2022.115140
Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol Preparation Products And Raw materials
Raw materials
Preparation Products
Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Winherb Medical Technology Co., Ltd. | 021-38218169 13341702378 | winherb@126.com | China | 1007 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6905 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Shanghai ChengShao Biological Technology Co., Ltd. | 021-61847300 13341622919 | shcss01@163.com | China | 4808 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229,4000369963 18080489829 | 3004654993@qq.com | China | 8208 | 60 |
| Shanghai Standard Technology Co.,Ltd. | 021-021-57127007-6622-6622 17621252073 | luzh@nature-standard.com | China | 3021 | 58 |
