ChemicalBook >> CAS DataBase List >>GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA

GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA

CAS No.
99026-77-4
Chemical Name:
GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA
Synonyms
GKGAGLSLSRFSWGA;[ALA107]-MBP (104-118);[ALA107]-MBP FRAGMENT 104-118;[Ala107]-MBP (104-118) acetate Salt;[Ala107]-Myelin Basic Protein (104-118);[ALA107]-MYELIN BASIC PROTEIN FRAGMENT 104-118;[Ala107]-Myelin Basic Protein Fragment 104-118;GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA;L-Alanine, glycyl-L-lysylglycyl-L-alanylglycyl-L-leucyl-L-seryl-L-leucyl-L-seryl-L-arginyl-L-phenylalanyl-L-seryl-L-tryptophylglycyl- (9CI);(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[(2-aminoacetyl)amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]propanoic acid
CBNumber:
CB3236444
Molecular Formula:
C67H104N20O19
Molecular Weight:
1493.67
MDL Number:
MFCD00273540
MOL File:
99026-77-4.mol
MSDS File:
SDS
Last updated:2026-01-13 11:17:38
Product description Number Pack Size Price
[Ala107]-MBP(104-118) 1900 1 $137
[Ala107]-MBP(104-118) B5218 1mg $308
[ALA107]-MYELIN BASIC PROTEIN (104-118) 95.00% KIN0000844 1MG $697.34
[ALA107]-MYELIN BASIC PROTEIN (104-118) 95.00% KIN0000844 5MG $1206.98

GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA Properties

storage temp. −20°C
solubility Soluble to 1 mg/ml in 10% acetonitrile
form solid
color White
biological source human
Sequence H-Gly-Lys-Gly-Ala-Gly-Leu-Ser-Leu-Ser-Arg-Phe-Ser-Trp-Gly-Ala-OH
InChIKey PKKMMDDHSZRJTF-NBRSAOMZSA-N
UNSPSC Code 12352200
NACRES NA.26

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 1900 [Ala107]-MBP(104-118) 99026-77-4 1 $137 2021-12-16 Buy
ApexBio Technology B5218 [Ala107]-MBP(104-118) 99026-77-4 1mg $308 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000844 [ALA107]-MYELIN BASIC PROTEIN (104-118) 95.00% 99026-77-4 1MG $697.34 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000844 [ALA107]-MYELIN BASIC PROTEIN (104-118) 95.00% 99026-77-4 5MG $1206.98 2021-12-16 Buy
Product number Packaging Price Buy
1900 1 $137 Buy
B5218 1mg $308 Buy
KIN0000844 1MG $697.34 Buy
KIN0000844 5MG $1206.98 Buy

GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA Chemical Properties,Uses,Production

Uses

[Ala107]MBP(104-118) is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 46-145 μM[1].

Biological Activity

[ala107]-mbp (104-118) is a non-competitive inhibitor of pkc and synthetic peptide analog of bovine myelin basic protein (mbp) with ic50 value of 46 - 145 mm.1. substrate specificity of phospholipid/ca2+ dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein. turner et al. j.biol.chem., 1985;260:115032. synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase c). su et al. biochem.biophys.res.commun., 1986;134:78

Biochem/physiol Actions

[Ala107]-Myelin Basic Protein Fragment 104-118 is an inhibitor of protein kinase C.

IC 50

PKC: 46-145 μM (IC50)

References

[1] Su HD, et, al. Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C). Biochem Biophys Res Commun. 1986 Jan 14; 134(1): 78-84. DOI:10.1016/0006-291x(86)90529-2

GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA Preparation Products And Raw materials

Raw materials

Preparation Products

GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA Suppliers

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GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA [ALA107]-MBP (104-118) [ALA107]-MBP FRAGMENT 104-118 [ALA107]-MYELIN BASIC PROTEIN FRAGMENT 104-118 (2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[(2-aminoacetyl)amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]propanoic acid [Ala107]-Myelin Basic Protein (104-118) L-Alanine, glycyl-L-lysylglycyl-L-alanylglycyl-L-leucyl-L-seryl-L-leucyl-L-seryl-L-arginyl-L-phenylalanyl-L-seryl-L-tryptophylglycyl- (9CI) GKGAGLSLSRFSWGA [Ala107]-MBP (104-118) acetate Salt [Ala107]-Myelin Basic Protein Fragment 104-118 99026-77-4 C67H104N20O19 Protein Kinase