m-(Methylamino)phenol
- CAS No.
- 14703-69-6
- Chemical Name:
- m-(Methylamino)phenol
- Synonyms
- 3-(Methylamino)phenol;m-(Methylamino)phenol;N-Methyl-m-aminophenol;Phenol, 3-(methylamino)-;N-Methyl-m-hydroxyaniline;m-Hydroxy-N-methylaniline;Neostigmine bromide Impurity G;Neostigmine bromide Impurity 13
- CBNumber:
- CB32405976
- Molecular Formula:
- C7H9NO
- Molecular Weight:
- 123.15
- MDL Number:
- MFCD16998628
- MOL File:
- 14703-69-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HS Code | 2922290090 |
m-(Methylamino)phenol price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M287503-50MG | 3-(methylamino)phenol | 14703-69-6 | 50mg | $94 | 2026-06-03 | Buy |
| TRC | TRC-M287503-500MG | 3-(methylamino)phenol | 14703-69-6 | 500mg | $460 | 2026-06-03 | Buy |
| TRC | TRC-M287503-100MG | 3-(methylamino)phenol | 14703-69-6 | 100mg | $127 | 2026-06-03 | Buy |
| Apolloscientific | OR941589 | 3-(Methylamino)phenol 95% | 14703-69-6 | 100mg | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR941589 | 3-(Methylamino)phenol 95% | 14703-69-6 | 250mg | $41 | 2026-06-04 | Buy |
m-(Methylamino)phenol Chemical Properties, Uses, Production
Synthesis
591-27-5
109-94-4
14703-69-6
Example 8A Synthesis of 3-(methylamino)phenol: 3-aminophenol (5.37 g, 49.2 mmol) was dissolved in methyl acetate (30 mL), p-toluenesulfonic acid (50 mg) was added as a catalyst, and the reaction was heated to reflux for 18 hours. Upon completion of the reaction, the volatile solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate, washed sequentially with 1N HCl, saturated NaHCO3 solution and brine, dried with Na2SO4 and filtered, and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was dissolved in tetrahydrofuran (THF, 25 mL), 1M borane tetrahydrofuran complex (27.2 mL, 27.2 mmol) of THF solution was added and the reaction was carried out for 18 h at room temperature. At the end of the reaction, the reaction was quenched by careful addition of 1N HCl and stirred for 30 min before the reaction solution was alkalized and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over Na2SO4 and filtered and the filtrate was concentrated under reduced pressure. The residue was purified by fast chromatography (30% ethyl acetate/hexane as eluent) to afford the target compound 3-(methylamino)phenol as a viscous yellow oil (1.72 g, 28% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and mass spectrometry (DCI/NH3): 1H NMR δ 7.03 (t, 1H), 6.13-6.24 (m, 2H), 6.11 (t, 1H), 4.54 (bs, 1H), 3.72 (bs, 1H), 2.82 (s, 3H); MS m/z 124 (M + H )+, 141 (M + NH4)+.
References
[1] Patent: US2004/19042, 2004, A1. Location in patent: Page/Page column 9-10
m-(Methylamino)phenol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4908 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
