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Ethyl 5-phenyl-3-isoxazolecarboxylate

Ethyl 5-phenyl-3-isoxazolecarboxylate structure

CAS No.: 13599-24-1

Chemical Name:: Ethyl 5-phenyl-3-isoxazolecarboxylate

Synonyms: TIMTEC-BB SBB014614;ethyl 3-phenyl-5-isoxazolecarboxylate

CBNumber:: CB32446692

Molecular Formula:: C12H11NO3

Molecular Weight:: 217.22

MDL Number:: MFCD01596796

MOL File:: 13599-24-1.mol

Last updated:2026-09-12 18:51:52

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Ethyl 5-phenyl-3-isoxazolecarboxylate Properties

Melting point	47 °C
Boiling point	379.8±30.0 °C(Predicted)
Density	1.173±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	-4.43±0.50(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

Ethyl 5-phenyl-3-isoxazolecarboxylate price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	302655	Ethyl 3-phenylisoxazole-5-carboxylate	13599-24-1	1.00g	$62	2026-05-19	Buy
Matrix Scientific	302655	Ethyl 3-phenylisoxazole-5-carboxylate	13599-24-1	5.00g	$224	2026-05-19	Buy
Matrix Scientific	302655	Ethyl 3-phenylisoxazole-5-carboxylate	13599-24-1	10.00g	$400	2026-05-19	Buy
aablocks	AA009X9M	Ethyl 3-phenylisoxazole-5-carboxylate 97%	13599-24-1	250mg	$21	2026-05-28	Buy
aablocks	AA009X9M	Ethyl 3-phenylisoxazole-5-carboxylate 97%	13599-24-1	1g	$46	2026-05-28	Buy

Product number	Packaging	Price	Buy
302655	1.00g	$62	Buy
302655	5.00g	$224	Buy
302655	10.00g	$400	Buy
AA009X9M	250mg	$21	Buy
AA009X9M	1g	$46	Buy

Ethyl 5-phenyl-3-isoxazolecarboxylate Chemical Properties, Uses, Production

Synthesis

81745-44-0

623-47-2

13599-24-1

General procedure for the synthesis of ethyl 3-phenylisoxazole-5-carboxylate from (E)-N-hydroxybenzimidoyl chloride and ethyl propargylate: preparation of the intermediate 54-ethyl S-phenylisoxazole-δ-carboxylic acid ethyl ester. The reaction was carried out by stirring ethyl propiolate (0.657 mL, 6.43 mmol), (E)-N-hydroxybenzenecarboximidoyl chloride (0.500 g, 3.21 mmol), and sodium bicarbonate (0.818 g, 9.64 mmol) in a mixed solvent of ethyl acetate (16 mL) and water (1 mL) at room temperature overnight. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The crude product was purified by fast column chromatography on silica gel, the eluent being a heptane solution of 5% to 80% dichloromethane, to give 0.295 g of ethyl 3-phenylisoxazole-5-carboxylate in 42% yield.ESI/APCI (+): 218 (M + H).

References

[1] Patent: WO2010/142801, 2010, A1. Location in patent: Page/Page column 162-163

Ethyl 5-phenyl-3-isoxazolecarboxylate Preparation Products And Raw materials

Raw materials

Benzaldoxime alpha-Chlorobenzaldoxime Ethyl propiolate Sodium bicarbonate

Preparation Products

Ethyl 5-phenyl-3-isoxazolecarboxylate Suppliers

Global Suppliers ( 29)

Supplier	Tel	Email	Country	ProdList	Advantage
SynAsst Chemical.	021-60343070		China	12731	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
ShangHai D&B Biological Science and Technology Co.Ltd	400-008-9730,021-54359730 400-008-9730	info@chemxyz.com	China	3642	60
Shanghai Tombiopharma Chemical Co. Ltd.	13391076197	tombiopharma@163.com	China	4986	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Shanghai Anmike Chemical Co. Ltd.	微信 18019252918 18019252918	sale@amkchem.com	China	9988	55
Nanjing BAM Biomedical Technology Co., Ltd.	18066080842 13952020641	bamd@foxmail.com	China	774	55
Shanghai Jinsheng Pharmaceutical Co., Ltd.	1365-13651960330 13651960330	xiangfeixia@jspharmatech.com	China	401	58
Aikon International Limited	025-58859352 13913916777	dt3@aikonchem.com	China	15490	58
Shanghai Chenghe Medical Technology Co. Ltd.	021-021-54382182 18601603956	18601603956@163.com	China	1326	58

Supplier	Advantage
SynAsst Chemical.	55
Bide Pharmatech Ltd.	60
ShangHai D&B Biological Science and Technology Co.Ltd	60
Shanghai Tombiopharma Chemical Co. Ltd.	55
Amadis Chemical Company Limited	58
Shanghai Anmike Chemical Co. Ltd.	55
Nanjing BAM Biomedical Technology Co., Ltd.	55
Shanghai Jinsheng Pharmaceutical Co., Ltd.	58
Aikon International Limited	58
Shanghai Chenghe Medical Technology Co. Ltd.	58

View Latest Price from Ethyl 5-phenyl-3-isoxazolecarboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-25	ETHYL 3-PHENYLISOXAZOLE-5-CARBOXYLATE 13599-24-1	$2.20-8.80	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2026-08-25	3-Phenylisoxazole-5-carboxylic acid 13599-24-1	$2.20-8.80	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

ETHYL 3-PHENYLISOXAZOLE-5-CARBOXYLATE
13599-24-1
$2.20-8.80
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

3-Phenylisoxazole-5-carboxylic acid
13599-24-1
$2.20-8.80
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Ethyl 5-phenyl-3-isoxazolecarboxylate Spectrum

ETHYL 5-PHENYL-3-ISOXAZOLECARBOXYLATE(13599-24-1)¹HNMR

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TIMTEC-BB SBB014614 ethyl 3-phenyl-5-isoxazolecarboxylate 13599-24-1