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Rizatriptan

Rizatriptan structure

CAS No.: 144034-80-0

Chemical Name:: Rizatriptan

Synonyms: CS-281;RIZATRIPTAN;Rizatriptan-d3;Rizatriptan USP/EP/BP;Rizatriptan###144034-80-0;2-(5-((1H-1,2,4-Triazol-1-yl);Acetochlor Impurity 3 (Butachlor);N,N-Dimethyl-5-(1H-1,2,4-trizol-1-ylmethyl)-1H-indole-3-ethanamine;n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine;1H-Indole-3-ethanaMine,N,N-diMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)-

CBNumber:: CB3245026

Molecular Formula:: C15H19N5

Molecular Weight:: 269.34

MDL Number:: MFCD03840591

MOL File:: 144034-80-0.mol

MSDS File:: SDS

Last updated:2026-05-28 01:04:18

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Rizatriptan Properties

Melting point	178-180°C
Boiling point	504.8±60.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	16.98±0.30(Predicted)
Water Solubility	42 mg/mL
InChI	InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3
InChIKey	ULFRLSNUDGIQQP-UHFFFAOYSA-N
SMILES	N1C2=C(C=C(CN3C=NC=N3)C=C2)C(CCN(C)C)=C1
CAS DataBase Reference	144034-80-0(CAS DataBase Reference)
FDA UNII	51086HBW8G
ATC code	N02CC04
EPA Substance Registry System	Acetonitrile, 2,2-dibromo-2-chloro- (144034-80-0)

Pharmacokinetic data

Protein binding	14%
Excreted unchanged in urine	14%
Volume of distribution	110 Litres (females), 140 Litres (males)
Biological half-life	2-3 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H319-H361-H372-H336
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501

Rizatriptan price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA001IQT	N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine ≥98%	144034-80-0	5mg	$20	2026-05-28	Buy
aablocks	AA001IQT	N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine ≥98%	144034-80-0	25mg	$40	2026-05-28	Buy
aablocks	AA001IQT	N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine	144034-80-0	100mg	$128	2026-05-28	Buy
ACHEMBLOCK	AD264399	Rizatriptan 98%	144034-80-0	250MG	$175	2026-05-27	Buy
ACHEMBLOCK	AD264399	Rizatriptan 98%	144034-80-0	1G	$460	2026-05-27	Buy

Product number	Packaging	Price	Buy
AA001IQT	5mg	$20	Buy
AA001IQT	25mg	$40	Buy
AA001IQT	100mg	$128	Buy
AD264399	250MG	$175	Buy
AD264399	1G	$460	Buy

Rizatriptan Chemical Properties, Uses, Production

Uses

Rizatriptan is reported to be a very effective acute migraine drug. It is reported to display high agonist activity at mainly the serotonin 5-HT1B and 5-HT1D receptor subtypes.

Uses

Ca channel blocker

Definition

ChEBI: Rizatriptan is a member of tryptamines. It has a role as a serotonergic agonist, a vasoconstrictor agent and an anti-inflammatory drug. It is functionally related to a N,N-dimethyltryptamine.

brand name

Maxalt (Merck).

General Description

Rizatriptan, approved in 1998, is a fast-acting triptan becauseof its moderate lipophilicity yet has a very shortelimination half-life similar to sumatriptan (i.e., like sumatriptan,it is mainly metabolized by MAO-A). The only advantagesof this drug when compared with sumatriptan arethat it has a slightly faster onset and that it has an orallydisintegrating tablet formulation which can be taken withoutwater.

Clinical Use

5HT1 receptor agonist:
Acute treatment of migraine

Drug interactions

Potentially hazardous interactions with other drugs
Antidepressants: increased risk of CNS excitation with citalopram - avoid; risk of CNS toxicity with MAOIs, moclobemide and linezolid - avoid for 2 weeks after discontinuation of MAOI and moclobemide; possibly increased serotonergic effects with duloxetine and venlafaxine; increased serotonergic effects with St John’s wort - avoid.
Dapoxetine: possible increased risk of serotonergic effects - avoid for 2 weeks after stopping 5HT1 agonists.
Ergot alkaloids: increased risk of vasospasm - avoid.
Propranolol: rizatriptan levels increased, reduce dose of rizatriptan to 5 mg (max 10 mg in 24 hours).

Metabolism

The main route of rizatriptan metabolism is via oxidative deamination by monoamine oxidase-A (MAO-A) to the indole acetic acid metabolite, which is not pharmacologically active. N-monodesmethyl-rizatriptan, a metabolite with activity similar to that of parent compound, is formed to a minor degree, but does not contribute significantly to the pharmacodynamic activity of rizatriptan.
Less than 1% is excreted in the urine as active N-monodesmethyl metabolite.

Rizatriptan Preparation Products And Raw materials

Raw materials

Preparation Products

Rizatriptan Suppliers

Global Suppliers ( 146)

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Istare Biotechnology Co., Ltd.	18682931470; 18682931470	2142355700@qq.com	China	4412	58
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
Nanjing Sunlida Biological Technology Co., Ltd.	025-57798810 18652991625	sales@sunlidabio.com	China	3223	55
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8039	58
Shanghai HuanChuan Industry Co.,Ltd.	021-61478794	sales@hcshhai.com	China	9781	50
Credit Asia Chemical Co., Ltd.	+86 (21) 61124340		China	9739	58
Chizhou Kailong Import and Export Trade Co., Ltd.		xg01_gj@163.com	China	9413	50
Guangzhou Ciming Biological Technology Co., Ltd.	020-38082199,29065168,38082986,29878298,29866629,4000192398		China	826	60
Shanghai Qiao Chemical Science Co., Ltd	021-58892003	info@qiaochem.com	China	6065	65

Supplier	Advantage
Shaanxi Istare Biotechnology Co., Ltd.	58
Capot Chemical Co., Ltd	66
Beijing HuaMeiHuLiBiological Chemical	58
Nanjing Sunlida Biological Technology Co., Ltd.	55
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
Shanghai HuanChuan Industry Co.,Ltd.	50
Credit Asia Chemical Co., Ltd.	58
Chizhou Kailong Import and Export Trade Co., Ltd.	50
Guangzhou Ciming Biological Technology Co., Ltd.	60
Shanghai Qiao Chemical Science Co., Ltd	65

View Latest Price from Rizatriptan manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-12	Rizatriptan 144034-80-0		10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD
2026-03-12	Rizatriptan 144034-80-0		10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD
2026-02-02	Rizatriptan 144034-80-0	$1.00	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd

Rizatriptan
144034-80-0
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

Rizatriptan
144034-80-0
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

Rizatriptan
144034-80-0
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

Rizatriptan Spectrum

Rizatriptan(144034-80-0)¹HNMR

144034-80-0 (Rizatriptan) Related Search:

Sumatriptan Dimethyl phthalate Dimethyl carbonate 1,2,4-Triazole 1H-Benzotriazole

Indole Dimethyl ether 5-Methyl-1H-benzotriazole Zolmitriptan Dacthal

Dimethyl fumarate Dimethyl sulfate Almotriptan Dimethyl disulfide Dimethyl sulfoxide

N,N-Dimethylformamide Ethane Voriconazole

1of4

n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethanamine RIZATRIPTAN diMethyl({2-[5-(1H-1,2,4-triazol-1-ylMethyl)-1H-indol-3-yl]ethyl})aMine 2-(5-((1H-1,2,4-Triazol-1-yl)Methyl)-1H-indol-3-yl)-N,N-diMethylethanaMine 1H-Indole-3-ethanaMine,N,N-diMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)- Rizatriptan###144034-80-0 2-(5-((1H-1,2,4-Triazol-1-yl) CS-281 Rizatriptan USP/EP/BP N,N-Dimethyl-5-(1H-1,2,4-trizol-1-ylmethyl)-1H-indole-3-ethanamine Rizatriptan-d3 RizatriptanQ: What is Rizatriptan Q: What is the CAS Number of Rizatriptan Q: What is the storage condition of Rizatriptan Q: What are the applications of Rizatriptan 3-[2-(Dimethylamino) ethyl]- 5- (1,2,4- triazol-1- ylmethyl) -indole Acetochlor Impurity 3 (Butachlor) 144034-80-0 NORVASC Other APIs