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ChemicalBook >> CAS DataBase List >>N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide

N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide

N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide Structure
N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide structure
CAS No.
54130-36-8
Chemical Name:
N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide
Synonyms
PGF2ALPHA-NET;Prostaglandin F2α ethyl amide;PROSTAGLANDIN F2ALPHA ETHYL AMIDE;N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide;Prosta-5,13-dien-1-amide, N-ethyl-9,11,15-trihydroxy-, (5Z,9α,11α,13E,15S)- (9CI);(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
CBNumber:
CB3245107
Molecular Formula:
C22H39NO4
Molecular Weight:
381.55
MDL Number:
MFCD03411992
MOL File:
54130-36-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:52
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N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide Properties

storage temp. Store at -20°C
solubility DMF: 33mg/ml; DMSO: 16 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 300 μg/ml

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H319-H360-H336
Precautionary statements  P201-P202-P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16016 Prostaglandin F2α ethyl amide ≥98% 54130-36-8 1mg $60 2026-04-30 Buy
Cayman Chemical 16016 Prostaglandin F2α ethyl amide ≥98% 54130-36-8 5mg $255 2026-04-30 Buy
Cayman Chemical 16016 Prostaglandin F2α ethyl amide ≥98% 54130-36-8 10mg $451 2026-04-30 Buy
ChemScene CS-0067591 Prostaglandin F2α ethyl amide 54130-36-8 1mg $129 2026-06-04 Buy
ChemScene CS-0067591 Prostaglandin F2α ethyl amide 54130-36-8 5mg $550 2026-06-04 Buy
Product number Packaging Price Buy
16016 1mg $60 Buy
16016 5mg $255 Buy
16016 10mg $451 Buy
CS-0067591 1mg $129 Buy
CS-0067591 5mg $550 Buy

N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide Chemical Properties, Uses, Production

Description

Prostaglandin F2α ethyl amide (PGF2α-NEt) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. PGF2α-NEt would be expected to show the typical intraocular effects of PGF2α free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.

Uses

Prostaglandin F2α ethyl amide is an analog of Prostaglandin F2α (HY-12956). Prostaglandin F2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191)[1].

References

[1] Bito LZ. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res. 1984 Feb;38(2):181-94. DOI:10.1016/0014-4835(84)90102-7

N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide Suppliers

Global Suppliers ( 10)
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29873 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

54130-36-8 (N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide) Related Search:

N,N-Diethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide N-(2-Hydroxyethyl)-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide-3,3,4,4-d4 N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide Dinoprost ethanolamide N-[(2-Hydroxy-1-hydromethyl)ethyl]-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide
PROSTAGLANDIN F2ALPHA-BIOTINIMIDE

1of2

PROSTAGLANDIN F2ALPHA ETHYL AMIDE PGF2ALPHA-NET Prostaglandin F2α ethyl amide (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]-N-ethylhept-5-enamide Prosta-5,13-dien-1-amide, N-ethyl-9,11,15-trihydroxy-, (5Z,9α,11α,13E,15S)- (9CI) N-Ethyl-9alpha, 11alpha, 15s-trihydroxy-prosta-5z, 13e-dien-1-amide 54130-36-8