NBI 6024
- CAS No.
- 239480-61-6
- Chemical Name:
- NBI 6024
- Synonyms
- NBI 6024;Glycine, L-seryl-L-histidyl-L-leucyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-valyl-L-alanylglycyl-L-alpha-glutamyl-L-arginyl-
- CBNumber:
- CB32451322
- Molecular Formula:
- C66H112N20O21
- Molecular Weight:
- 1521.73
- MDL Number:
- MFCD09837858
- MOL File:
- 239480-61-6.mol
- TDS File:
- TDS
| FDA UNII | OMF3CT7D4L |
|---|
NBI 6024 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00BX4X | NBI 6024 ≥95% | 239480-61-6 | 1mg | $167 | 2026-05-28 | Buy |
| aablocks | AA00BX4X | NBI 6024 ≥95% | 239480-61-6 | 5mg | $393 | 2026-05-28 | Buy |
| aablocks | AA00BX4X | NBI 6024 ≥95% | 239480-61-6 | 10mg | $543 | 2026-05-28 | Buy |
| American Custom Chemicals Corporation | API0019355 | L-SERYL-L-HISTIDYL-L-LEUCYL-L-VALYL-L-A-GLUTAMYL-L-ALANYL-L-LEUCYL-L-ALANYL-L-LEUCYL-L-VALYL-L-ALANYLGLYCYL-L-A-GLUTAMYL-L-ARGINYL-GLYCINE 95.00% | 239480-61-6 | 5MG | $504.78 | 2021-12-16 | Buy |
NBI 6024 Chemical Properties, Uses, Production
Uses
NBI-6024, an altered peptide ligand (APL), is an epitope recognized by inflammatory interferon-gamma-producing T helper lymphocytes in type 1 diabetic patients[1][2].
in vivo
NBI-6024 (0.005-20 mg/kg, s.c.) delays the onset and reduces the incidence of diabetes in mice[2].
| Animal Model: | Nonobese diabetic (NOD) mice[2] |
| Dosage: | 0.005, 0.05, 0.5, 5, 10, 20 mg/kg |
| Administration: | Subcutaneous injection (s.c.) |
| Result: | Observed dose-dependent induction of responsiveness to the immunizing antigen at 5, 10, 20 mg/kg (tested by culturing spleen cells pooled from mice). |
References
[1] D G Alleva et al. Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope. Scand J Immunol. 2006 Jan;63(1):59-69. DOI:10.1111/j.1365-3083.2005.01705.x
[2] Alleva DG, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes. 2002 Jul;51(7):2126-34. DOI:10.2337/diabetes.51.7.2126
NBI 6024 Preparation Products And Raw materials
Raw materials
Preparation Products
NBI 6024 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai HongTide Biotechnology Co.,Ltd. | 15318089928 | alex@hanhonggroup.com | China | 4604 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| YantaiBio | 13758194781; 13758194781 | 764619768@qq.com | China | 1755 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai HongTide Biotechnology Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| YantaiBio | 58 |
