Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate Structure
tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate structure
CAS No.
733757-89-6
Chemical Name:
tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate
Synonyms
6-Boc-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine;tert-butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydropyrazolo[3,4-c]pyridine-6-carboxylate;tert-Butyl 3-(trifluoroMethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate;tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate;3-Trifluoromethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester;"3-TrifluoroMethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridine-6-carboxylic acid tert-butyl ester";6H-Pyrazolo[3,4-c]pyridine-6-carboxylic acid, 1,4,5,7-tetrahydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester
CBNumber:
CB32455562
Molecular Formula:
C12H16F3N3O2
Molecular Weight:
291.27
MDL Number:
MFCD11044974
MOL File:
733757-89-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:52
Request For Quotation

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate Properties

Boiling point 368.4±42.0 °C(Predicted)
Density 1.326±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 11.49±0.20(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
HS Code  2933399990

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC48634 tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate 95% 733757-89-6 5g $661 2026-06-04 Buy
Matrix Scientific 188158 tert-butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate 733757-89-6 1.00g $108 2026-05-18 Buy
Matrix Scientific 188158 tert-butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate 733757-89-6 5.00g $527 2026-05-18 Buy
Matrix Scientific 188158 tert-butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate 733757-89-6 10.00g $1051 2026-05-18 Buy
Synthonix B56045 tert-Butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate 95+% 733757-89-6 100mg $26 2026-05-06 Buy
Product number Packaging Price Buy
PC48634 5g $661 Buy
188158 1.00g $108 Buy
188158 5.00g $527 Buy
188158 10.00g $1051 Buy
B56045 100mg $26 Buy

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate Chemical Properties, Uses, Production

Synthesis

tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

647863-25-0

TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE

733757-89-6

The general procedure for the synthesis of tert-butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate using tert-butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate as a starting material was as follows: to a solution of 1-tert-butyloxycarbonyl-4-(trifluoroacetyl)-3-piperidinone (23.6 g, 0.08 mol) (4.16 ml, 0.086 mol) was added to a solution of ethanol (250 ml) with hydrazine monohydrate (4.16 ml, 0.086 mol). The reaction mixture was stirred at 50°C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The concentrated residue was partitioned between ethyl acetate and saturated brine. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was recrystallized by ethyl acetate/n-pentane mixed solvent to afford the target compound tert-butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate as a light yellow solid (6.5 g, 28% yield). The product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 11.13 (1H, broad single peak), 4.40 (2H, multiple peaks), 3.66 (2H, multiple peaks), 2.70 (2H, multiple peaks), 1.48 (9H, single peak); the LC/MS analysis showed a retention time of 2.90 min, and a mass spectrometry (ES-) m/z 290 ([M- H]-, calculated value of C12H16F3N3O2 has a molecular weight of 291).

References

[1] Patent: US2010/137276, 2010, A1. Location in patent: Page/Page column 17-18
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 1, p. 78 - 94
[3] Patent: WO2008/113795, 2008, A1. Location in patent: Page/Page column 42
[4] Patent: WO2008/148832, 2008, A1. Location in patent: Page/Page column 40

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate Preparation Products And Raw materials

Raw materials

tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate Ethanol Hydrazine hydrate

Preparation Products

6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate Suppliers

Global Suppliers ( 43)
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
SynAsst Chemical. 021-60343070 China 12731 55
Bellen Chemistry Co., Ltd. 010-60400365-8001 15910885229 service@bellenchem.com China 4514 60
Shanghai JingRon Chemical Technology Co., Ltd. 021-60546673 13701861782; kuanga111@sina.com China 882 58
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 6746 58
Aikon International Limited 025-58859352 13913916777 dt3@aikonchem.com China 15490 58
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
Shanghai Hanhong Scientific Co.,Ltd. 64
SuZhou ShiYa Biopharmaceuticals, Inc. 58
SynAsst Chemical. 55
Bellen Chemistry Co., Ltd. 60
Shanghai JingRon Chemical Technology Co., Ltd. 58
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Amadis Chemical Company Limited 58
Cochemical Ltd. 58
Aikon International Limited 58

View Latest Price from tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-Butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate pictures 2020-02-05 tert-Butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate
733757-89-6
 $1.00 1KG Min98% HPLC Career Henan Chemical Co

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate Spectrum

TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE(733757-89-6)1HNMRTERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE(733757-89-6)19FNMR

733757-89-6 (tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate) Related Search:

tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine tert-butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate 6H-Pyrazolo[3,4-c]pyridine-6-carboxylic acid, 2,4,5,7-tetrahydro-, 1,1-dimethylethyl ester 3-TrifluoroMethyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine hydrochloride
6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

1of2

tert-Butyl 3-(trifluoroMethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate "3-TrifluoroMethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridine-6-carboxylic acid tert-butyl ester" 3-Trifluoromethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester 6H-Pyrazolo[3,4-c]pyridine-6-carboxylic acid, 1,4,5,7-tetrahydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester 6-Boc-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine tert-butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydropyrazolo[3,4-c]pyridine-6-carboxylate tert-Butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate 733757-89-6